New activators for the completion of phagocytosis to prevent the reactivation of the tuberculosis process

Authors

  • Artur Martynov Mechnikov Institute of microbiology and immunology, Ukraine
  • Olena Romanova Mechnikov Institute of Microbiology and Immunology of the National Academy of Medical Sciences of Ukraine , Ukraine
  • Marina Pohorila Mechnikov Institute of Microbiology and Immunology of the National Academy of Medical Sciences of Ukraine , Ukraine
  • Tetyana Sydorenko Mechnikov Institute of Microbiology and Immunology of the National Academy of Medical Sciences of Ukraine , Ukraine
  • Natalia Igumnova Mechnikov Institute of Microbiology and Immunology of the National Academy of Medical Sciences of Ukraine , Ukraine
  • Vera Yukhimenko Mechnikov Institute of Microbiology and Immunology of the National Academy of Medical Sciences of Ukraine , Ukraine
  • Olena Shcherbak Mechnikov Institute of Microbiology and Immunology of the National Academy of Medical Sciences of Ukraine , Ukraine

Abstract

In order to develop dosage forms for the prevention of reactivation of latent tuberculosis, several pharmaceutical compositions were synthesized, from which the most effective activator of phagocytosis completion - succinylformyllysine - was selected. It was found that the use of succinylformillisin increases the functional activity of T-lymphocytes and peritoneal macrophages, normalizes the leukogram of the blood. The most effective composition of diprion and cholecalciferol, capable of inhibiting mycobacterial urease and selective activation of the functional ability of phagocytes and lymphocytes, has also been developed. The aerosol mixture based on these compounds is able to reduce by 37% the number of macrophages with incomplete phagocytosis in the lungs of mice infected with BCG on the background of immunosuppression.

DOI: 10.5281/zenodo.5499622

Published

2021-09-10

How to Cite

Martynov, A., Romanova, O., Pohorila, M., Sydorenko, T., Igumnova, N., Yukhimenko, V., & Shcherbak, O. (2021). New activators for the completion of phagocytosis to prevent the reactivation of the tuberculosis process. Annals of Mechnikov’s Institute, (3), 79–83. Retrieved from http://journals.uran.ua/ami/article/view/239833

Issue

Section

Articles