Extemporaneous suspensions in the scheme of complex therapy of dermatological skin diseases

Authors

  • Svitlana Zujkina National University of Pharmacy, Ukraine http://orcid.org/0000-0002-7546-6062
  • Shtuchna Nataliya National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.5281/zenodo.7071075

Abstract

The relevance of the study of acne (Acne vulgaris) depends on its significant prevalence among young and middle-aged people and the chronic course of the disease, resistance to conventional therapy, and impaired psycho-emotional status and social adaptation in patients. Acne affects 9.4 % of the world’s population. Therefore, this disease remains one of the most common problems in the practice of dermatologists and cosmetologists. In 64 and 43 % of people, acne persists until the age of 20-30, respectively, and suicidal thoughts are more common in those with severe forms of acne than with mild ones. In the United States, the cost of acne in terms of treatment and productivity loss is over $ 3 billion per year. The aim of the work was to study the prospects for the use of extemporaneous remedies in the form of suspensions for external use in the scheme of complex acne treatment. In the aspect of the researched problem, the materials of State Register of Medicinal Products of Ukraine, Protocol on the provision of medical assistance to patients with vulgar acne, Addendum to the order of the Ministry of Health No. 312 of 08-05-2009, the provisions of the guidelines of the American Academy of Dermatology on the treatment of patients with acne vulgaris and the Guidelines for the treatment of patients with acne vulgaris within the limits of primary and specialized medical care (Great Britain) were studied. Using pharmacotechnological methods, technology was developed and quality indicators of several extemporaneous suspensions for complex pharmacocorrection of acne were investigated.

Key words: aсne, drugs, extemporaneous suspension.

Author Biography

Svitlana Zujkina, National University of Pharmacy

Department of ATL, Associate Professor

References

Ulvestad M. Acne and dairy products in adolescence: results from a Norwegian longitudinal study. M. Ulvestad, E. Bjertness, F. Dalgard, J. A. Halvorsen. JEADV, Dermatol. аnd Venereol. 2017. Vol. 31 (3). P. 530–535.

Shtuchna N.I., Vishnevska L.I., Khomenko V.N. Study of the range of drugs for the treatment of dermatological skin diseases of extemporaneous production, N.I. Shtuchna, Modern aspects of creating extemporaneous allopathic, homeopathic and cosmetic of medicinal products: materials of IV International science and practice distance Conference, Kharkiv, March 20. 2020. Kharkiv. NFaU Publishing House. 2020. P. 147–150.

Monakhov S. A. Rational therapy of acne, Ukrainian journal of dermatology, venereology, cosmetology. 2016. No. 4 (63). P. 70–78.

Eichenfield Lawrence F. Evidence-based recommendations for the diagnosis and treatment of pediatric acne. Eichenfield Lawrence F., et al. Pediatrics. 2013. 131.Supplement 3. S.163–186.

Yu-Chen H., Ying-Chih C. Isotretinoin treatment for acne and risk of depression: A systematic review and meta-analysis, J. Am. Acad. Dermatol. 2017. N 76 (Issue 6). P. 1068–1076.

Heng Anna, Hwee Sing, Chew Fook Tim. Systematic review of the epidemiology of acne vulgaris. Scientific reports. 2020. 10.1. Р. 1–29.

Bhate K., Williams H. C. Epidemiology of acne vulgaris. British Journal of Dermatolog. 2013. 168.3. 474–485.

Tan Jerry; Kang, Sewon; Leyden, James. Prevalence and risk factors of acne scarring among patients consulting dermatologists in the USA. Journal of drugs in dermatology. JDD. 2017. 16.2. 97-102

Dreno B. Understanding innate immunity and inflammation in acne: implications for management. Dreno B., et al. Journal of the European Academy of Dermatology and Venereology. 2015. 29. Р. 3–11.

Acne. Evidence-based clinical practice. State Expert Center of the Ministry of Health of Ukraine. K. 2017. 101 p.

Ukrainian medical portal. Clinical recommendations for the management of Acne vulgaris. Dermatovenerology. 05/28/2019.

Zaidi Z. Acne vulgaris-an update on pathophysiology and treatment. J Pak Med Assoc. 2009.59(9).635-7. Review. PMID: 19750863.

Mariconda A. Acne the essential guide. 2018. P. 32.

Koval A. S. The choice of the method of introducing active substances into the base of the cream for the treatment of acne and demodicosis. Pharmaceutical journal. 2021. Vol. 76, No. 1. 2021.S. 50–56.

Sagransky M, Yentzer BA, Feldman SR. Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris. Expert Opin Pharmacother 2009.10(15).2555–62.

Acne: clinical guidelines NICE-2021. Savelyeva-Kulik N. O. Editorial Board of the journal "Ukrainian Medical Journal".

Protocol for providing medical care to patients with acne vulgaris. Appendix to the order of the Ministry of Health No. 312 dated 08-05-2009.

A brief overview of the guidelines of the American Academy of Dermatology for the treatment of patients with acne vulgaris. Health of Ukraine. No. 17 (390). 2016. pp. 19–20.

Compendium website URL: https://compendium.com.ua/uk/ (access date 07.28.2022).

State Pharmacopoeia of Ukraine: in 3 volumes. State enterprise "Ukrainian Scientific Pharmacopoeia Center for the Quality of Medicinal Products". - 2nd edition. - Kharkiv: State enterprise "Ukrainian Scientific Pharmacopoeia Center for the Quality of Medicines", 2014. Vol. 2. 724 p., 2015. Vol. 1. 1128 p., 2015. Vol. 3. 732 p.

European Pharmacopoeia. European Directorate for the Quality of Medicines & Health Care. 6th ed. Strasbourg, 2007. Vol. 1. 1086 p.

USP Pharmacists’ Pharmacopoeia. 2 nd ed. Rockville. 2008. 1519 p.

Pharmaceutical encyclopedia. The head of the ed. council and the author of the foreword V. P. Chernykh. 2nd ed., revised. and additional K. MORION. 2010. 1632 p.

Published

2022-09-12

How to Cite

Zujkina, S., & Nataliya, S. (2022). Extemporaneous suspensions in the scheme of complex therapy of dermatological skin diseases. Annals of Mechnikov’s Institute, (3), 54–61. https://doi.org/10.5281/zenodo.7071075

Issue

Section

Articles