The relationship between depressive disorders and the state of cognitive function in elderly patients with type 2 diabetes mellitus

Main Article Content

N.N. Zherdоva


Background. Depression is a risk factor of diabetes mellitus (DM) and negatively affects its course with an increased risk of complications. The aim of the study was to assess the state of cognitive function in elderly patients with type 2 DM (DM2) with and without depression. Materials and methods. 115 patients with DM2 were examined, including 78 women and 37 men. Patients were divided into 2 groups, with and without depressive disorders. Assessment of depressive symptoms was performed using self-questionnaire of depression (CES-D). Evaluation of cognitive manifestations was carried out in the morning with the following methods: “the 5 words” test, the Mini-Mental State Examination, Frontal Assessment Battery, clock drawing test. Results. In 68.7 % of elderly patients with DM2, we have not found depressive disorders according to CES-D, mild manifestations were observed in 17.4 % of patients, moderate — in 10.4 % and 3.5 % of patients had severe symptoms of depression. Persons with depressive disorders had a significant decline in cognitive function. In patients with DM with moderate to severe symptoms of depression, the state of cognitive function was significantly worse compared with patients, who have mild symptoms of depression or no depression. Conclusions. All patients with DM2 should be screened for the presence of depressive disorders in order to prevent violations of cognitive functions.

Article Details

How to Cite
Zherdоva N. “The Relationship Between Depressive Disorders and the State of Cognitive Function in Elderly Patients With Type 2 diabetes Mellitus”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 13, no. 2, May 2017, pp. 114-7, doi:10.22141/2224-0721.13.2.2017.100597.
Original Researches


Trief PM. Depression in Elderly Diabetes Patients. Diabetes Spectrum. 2007;20(2):71-5. doi: 10.2337/diaspect.20.2.71.

Kanaya AM, Barrett-Connor E, Gildengorin G, Yaffe K. Change in cognitive function by glucose tolerance status in older adults: a 4-year prospective study of the Rancho Bernardo study cohort. Arch Intern Med. 2004;164(12):1327-33. PMID:15226167. doi: 10.1001/archinte.164.12.1327.

Bruce DG, Casey GP, Grange V, Clarnette RC, Almeida OP, Foster JK, Ives FJ, Davis TM; Fremantle Cognitionin Diabetes Study. Cognitive impairment, physical disability, and depressive symptoms in older diabetes patients: the Fremantle Cognition in Diabetes Study. Diabetes Res Clin Pract. 2003;61(1):59-67. PMID: 12849924.

Lin EH, Von Korff MV, Alonso J, et al. Mental disorders among persons with diabetes — results from the World Mental Health Surveys. J Psychosom Res. 2008;65(6):571-80. PMID: 19027447. doi: 10.1016/j.jpsychores.2008.06.007.

Fischer L, Skaff MM, Mullan JT, Arean P, Glasgow R, Masharani U. A longitudinal study of affective and anxiety disorders, depressive affect and diabetes distress in adults with type 2 diabetes. Diabet Med. 2008;25(9):1096-101. PMID: 19183314.

De Groot M, Jacobson AM, Samson JA, Welch G. Glycemic control and major depression in patients with Type 1 and Type 2 diabetes mellitus. J Psychosom Res. 1999;46(5):425-35. PMID: 10404477.

Andreoulakis E, Hyphantis T, Kandylis D, Iacovides A. Depression in diabetes mellitus: a comprehensive review. Hippokratia. 2012;16(3):205-14. PMID: 23935284.

Egede LE, Zheng D. Independent factors associated with major depressive disorder in a national sample of individuals with diabetes. Diabetes Care. 2003;26(1):104-11. PMID: 12502665.

Papelbaum M, Moreira RO, Countinho W, et al. Depression, glycemic control and type 2 diabetes. Diabetol Metab Syndr. 2011;3(1):26. PMID: 21978660. doi: 10.1186/1758-5996-3-26.

Dirmaier J, Watzke B, Koch U, et al. Diabetes in primary care: prospective associations between depression, nonadherence and glycemic control. Psychother Psychosom. 2010;79(3):172-8. PMID: 20234147. doi: 10.1159/000296135.