Sarcopenia in type 2 diabetes mellitus (review and own observations)

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O.A. Goncharova


Background. A review of the literature on sarcopenia syndrome presents its definition, classifications and etiological factors. The main attention is paid to the correlation between sarcopenia and carbohydrate metabolism, in particular, between glycogen content and insulin sensitivity. The publications dealing with the mechanisms of influence of physical activity (short-term and long-term) on carbohydrate metabolism are analyzed. It is emphasized that today there is an evidence base on the role of skeletal muscles in maintaining glucose homeostasis, which justifies the importance of physical activity for the prevention of type 2 diabetes mellitus (DM) and monitoring such patients. Our observations were carried out to compare the frequency of the increase in the percentage of fat tissue (FT) and the reduction in muscle tissue in patients with different body mass index (BMI) and the effects of type 2 DM on these indicators. Materials and methods. A bioimpedance study was performed in 114 patients with type 2 DM aged 52.3 ± 1.7 years and 110 persons of the same age without type 2 DM (control group). Results. In all those surveyed with overweight and obesity, the age norms of percentage of FT were increased, regardless of the presence or absence of type 2 DM. At normal body weight in the control group in almost half of the examinees (52.0 %), there was an increase in the specific weight of the FT, and in the presence of type 2 DM, this index was significantly higher (94.1 %). This suggests that exceeding the age norms for the percentage of FT in persons with normal body weight can be regarded as a risk factor for type 2 DM. Conclusions. The incidence of a decrease in the specific weight of FT in the control group was 8.0 % in normal body weight, 20.0 % — in overweight and 80.0 % — in obesity that indicates the significance of the problem of sarcopenia, primarily in persons with obesity. Against the background of type 2 DM, these rates were significantly higher with normal body weight (41.2 %, p < 0.02), 2 times higher — with overweight, but lower (unreliably) — with obesity (61.1 %). The problem of sarcopenia in DM type 2 is relevant for patients with various BMI.

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Goncharova, O. “Sarcopenia in Type 2 diabetes Mellitus (review and Own Observations)”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 13, no. 2, May 2017, pp. 186-94, doi:10.22141/2224-0721.13.2.2017.100611.
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