Interconnection between metabolic syndrome components in obese patients

Main Article Content

E.G. Bayanova


Background. The aim of our study is to deter­mine intercommunication between the indexes of insulin resistance, С-peptide, leptin, cortisol, thyroid hormones in obese patients. Materials and methods. The study involved 30 persons with the average body mass index (BMI) 35.1 kg/м2. They were divided into three groups by this index depending on the obesity severity. Results. The indexes of insulin, С-peptide, HOMA index with the enhanced BMI had a tendency to the increase. Their average indexes were highest in patients with III stage obesity. An increased level of ТSH was determined for the 31 % patients of the first group, in 25 % patients of the second group and in 50 % patients of the third group. Free thyroxine (fТ4) level was highest in the patients of the second group, fТ4 indexes under 0.93 ng/dl were observed in 25 % patients of the first group and in 50 % patients of the third group. The cortisol level maximally rose in the patients of the second group and went down a little in the patients of the third group. The leptin indexes rose with the increase of BMI. Conclusions. Metabolic syndrome develops on a background of the decline of thyroid function and increase of insulin secretion.

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How to Cite
Bayanova, E. “Interconnection Between Metabolic Syndrome Components in Obese Patients”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 13, no. 2, May 2017, pp. 209-12, doi:10.22141/2224-0721.13.2.2017.100615.
Operational Experience


Waring AC, Rodondi N, Harrison S, Kanaya AM, Simonsick EM, Miljkovic I, Satterfield S, Newman AB, Bauer DC. Thyroid function and prevalent and incident metabolic syndrome in older adults: the health, ageing and body composition study. Clin Endocrinol (Oxf). 2012;76:911-8. PMID: 22187968. doi: 10.1111/j.1365-2265.2011.04328.x.

Cameron AJ, Magliano DJ, Zimmet PZ, Welborn TA, Colagiuri S, Tonkin AM, Shaw JE. The metabolic syndrome as a tool for predicting future diabetes: the AusDiab study. J Intern Med. 2008;264:177-86. PMID: 18298479. doi: 10.1111/j.1365-2796.2008.01935.x.

Alberti KG, Zimmet P, Shaw J. Metabolic syndrome — a new world-wide definition. A consensus statement from the international diabetes federation. Diabet Med. 2006 May;23(5):469-80. PMID: 16681555. doi: 10.1111/j.1464-5491.2006.01858.x.

 Duntas L, Micic D. Adiposopathy and thyroid disease: tracing the pathway to cardiovascular risk. Expert Rev Cardiovasc Ther. 2012 Jun;10(6):797-803. PMID: 22894634. doi: 10.1586/erc.12.47.

Lee YK, Kim JE, Oh HJ, Park KS, Kim SK, Park SW, Kim MJ, Cho YW. Serum TSH level in healthy Koreans and the association of TSH with serum lipid concentration and metabolic syndrome. Korean J Intern Med. 2011 Dec;26(4):432-9. PMID: 22205844. doi: 10.3904/kjim.2011.26.4.432.