Рівень глікемії та інсулінорезистентності у хворих на цукровий діабет 2-го типу, діабетичну ретинопатію та ожиріння

N.V. Malachkova; I.V. Komarovskaya; M.L. Kyryliuk

doi:10.22141/2224-0721.13.3.2017.104108

PDF (Русский)

DOI: https://doi.org/10.22141/2224-0721.13.3.2017.104108

Keywords:

type 2 diabetes mellitus, diabetic retinopathy, insulin resistance

N.V. Malachkova

M.I. Pirogov Vinnytsia National Medical University, Vinnytsia, Ukraine

I.V. Komarovskaya

M.I. Pirogov Vinnytsia National Medical University, Vinnytsia, Ukraine

M.L. Kyryliuk

Ukrainian Scientific and Practical Center of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of Ministry of Health of Ukraine, Kyiv, Ukraine

https://orcid.org/0000-0002-4996-8712

Abstract

Background. Diabetic retinopathy is the main cause of visual disorders in the world. The purpose of our work was to study the level of glycaemia and insulin resistance in patients with type 2 diabetes mellitus (DM), diabetic retinopathy and obesity. Materials and methods. One-hundred and seven diabetic patients (234 eyes) observed were divided in two groups. Results. The levels of blood glucose and insulin resistance were studied at different stages of diabetic retinopathy (DR) in patients with type 2 DM. Using ANOVA it was shown that all patients with DR, regardless of study group, had chronic hyperglycemia with decompensated T2DM. The carbohydrate metabolism was found to begin improving only at the 3rd stage of DR, however it occurs on a background of hypoglycemia. Conclusions. The greatest proportion of patients with adverse indices of insulin resistance by HOMA-IR index (87.5 ± 11.6%) and with reduced sensitivity to insulin by QUICKI index (62.5 ± 17.1 %) had proliferative DR stage compared to the comparative and control groups (obese patients without T2DM): 55.0 ± 11.1%; p < 0.001, and 25.0 ± 9.68 %; p < 0.001, respectively.

How to Cite

Malachkova, N., I. Komarovskaya, and M. Kyryliuk. “Blood Glucose Level and Insulin Resistance in Patients With Type 2 diabetic Mellitus, Diabetic Retinopathy and Obesity”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 13, no. 3, June 2017, pp. 129-34, doi:10.22141/2224-0721.13.3.2017.104108.

Issue

Vol. 13 No. 3 (2017)

Section

Original Researches

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