Dyshormonal states of the reproductive system in women after thyroidectomy and radioiodine therapy for differentiated thyroid carcinoma

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A.M. Kvachenyuk
T.M. Kuchmenko
Yu.M. Bozhok
A.V. Zelinskaya
Ye.A. Shelkovoy


Using ultrasound data and content of gonadotropin and sex hormones in the blood, the morphological and functional state of the mammary glands, the uterus and the ovaries were studied in women after thyroidectomy and radioiodine therapy, who were taken suppressive therapy with levothyroxine drugs that allows to estimate the hormonal supply of the menstrual cycle and the state of reproductive system. The signs of menstrual cycle disorders and luteal phase deficiency were revealed during the treatment, and dyshormonal hyperplasia of mammary glands was also diagnosed in 82.6 % of cases due to prolonged relative hyperestrogenism and hyperplastic diseases of the uterus and the ovaries, including genital endometriosis, endometrial hyperplasia, uterine myomas, were identified in 80.4 % of cases. A long-term monitoring (every 3 months) of thyroid-stimulating hormone, thyroglobulin, thyroglobulin antibodies, follicle-stimulating hormone, luteinizing hormone, prolactin, progesterone, free testosterone, estradiol levels and also the correction of cycle supply using hormonal and non-hormonal methods are needed for this category of patients.

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How to Cite
Kvachenyuk, A., T. Kuchmenko, Y. Bozhok, A. Zelinskaya, and Y. Shelkovoy. “Dyshormonal States of the Reproductive System in Women After Thyroidectomy and Radioiodine Therapy for Differentiated Thyroid Carcinoma”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 13, no. 3, June 2017, pp. 167-71, doi:10.22141/2224-0721.13.3.2017.104114.
To practicing Endocrinologists


Pankiv VI. The influence of thyroid disorders upon the female reproductive function. Reproductive Endocrinology. 2016;1(27):52-57. (In Ukrainian). doi: 10.18370/2309-4117.2016.27.52-57.

Redmond GP. Thyroid dysfunction and women reproductive health. Thyroid. 2004;14(1):5-15. doi: 10.1089/105072504323024543.

Apfelbaum ME, Taleisnsk S. Influence of estrogen administration in vivo and in vitro on the release and synthesis of prolactin from incubated pituitaries. Acta Endocrinol (Copenh). 1987;86(4):714-21. PMID: 579032.

Kawabata W, Suzuki T, Moria T, et al. Estrogen receptors in Thyroid disorders and 17beta-hydroxysteroid dehydrogenase type 1 and 2 in thyroid disorders: possible in situ estrogen synthesis and actions. Mod Pathol. 2003;16(5):437-44. doi: 10.1097/01.MP.0000066800.44492.1B.

Poppe K, Glinoer D, Tournaye H. Impact of ovarian hyperstimulation on thyroid function in women with and without thyroid autoimmunity. J Clin Endocrinol Metab. 2004 Aug;89(8):3808-12. doi: 10.1210/jc.2004-0105.

Pasiechko NV, Gnat SV, Svystun II, Naumova LV. Influence of Subclinical Hypothyroidism on Women Reproductive Function and Efficiency of its Correction. Mezhdunarodnyi Endokrinologicheskii Zhurnal. 2015;1(65):98-101. (In Ukrainian). doi: 10.22141/2224-0721.1.65.2015.75910.

Pashkovska NV. Thyroid disease and pregnancy. Mezhdunarodnyi Endokrinologicheskii Zhurnal. 2012;8(48):78-82. (In Ukrainian).

Haddow JE, Cleary-Goldman J, McClain MR. et al. Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery. Obstet Gynecol. 2010;116(1):58-62. doi: 10.1097/AOG.0b013e3181e10b30.

Krassas GE, Poppe K, Glinoer D. Thyroid Function and Human Reproductive Health. Endocr Rev. 2010;31(5):702-55. doi: 10.1210/er.2009-0041.

Lazarus JH. Epidemiology and prevention of thyroid disease in pregnancy. Thyroid. 2002;12(10):861-5. doi: 10.1089/105072502761016485.

Negro R, Schwartz A, Gismondi R, et al. Universal screening versus case finding for detection and treatment of thyroid hormonal dysfunction during pregnancy. J Clin Endocrinol Metab. 2010;95(4):1699-707. doi: 10.1210/jc.2009-2009.

Patil-Sisodia K, Mestman JH. Graves hyperthyroidism and pregnancy: a clinical update. Endocr Pract. 2010;16(1):118-29. doi: 10.4158/EP09233.RA.

Stagnaro-Green A. Оptimal care of the pregnant woman with thyroid disease. J Clin Endocrinol Metab. 2012;97(8):2619-22. doi: 10.1210/jc.2012-2380.

Stagnaro-Green А, Pearce E. Thyroid disorders in pregnancy. Nature Reviews Endocrinology. 2012;8(11):650-8. doi: 10.1038/nrendo.2012.171.

Yassa L, Marqusee E, Fawcett R, et al. Thyroid hormone early adjustment in pregnancy (the therapy) trial. J Clin Endocrinol Metab. 2010;95(7):3234-41. doi: org/10.1210/jc.2010-0013.

Agbajanova L, Lindeberg M, Carlsson IB. Receptors for thyroid-stimulating hormone and thyroid hormones in human ovarian tissue. Reprod Biomed. 2009;18(3):337-47. PMID: 19298732.