Pathogenetic significance of proinflammatory cytokines and dyslipidemia in the development of cardiovascular complications in patients with hypothyroidism

Main Article Content

V.S. Vernygorodskyi
N.M. Fetisova
M.V. Vernygorodska


Background. The manifestation of violations in the morphofunctional state of the cardiovascular system is on one of the first places in the symptomatology of hypothyroidism, which is associated with various direct and indirect effects of thyroid hormones on the heart and blood vessels. The urgency of the question about the prevalence and peculiarities of dyslipidemia in patients with different types of hypothyroidism is still open. The purpose of our work is to study the prevalence of subclinical inflammatory syndrome (by the levels of C-reactive protein and interleukin-6) and to investigate the relationship between dyslipidemia, proinflammatory factors and the state of blood vessels in patients with hypothyroidism. Materials and methods. 101 patients with hypothyroidism were examined. The content of interleukin-6, C-reactive protein was determined by the enzyme immunoassay using NSCRP, ELISA (USA), IL-6 ELISA (Diaclone, France) kits according to the manufacturer’s instructions. Results. It was found that levels of C-reactive protein were higher in patients with hypothyroidism than in euthyroid individuals. Also, the interleukin-6 content in patients with hypothyroidism was significantly higher (by 66.6 %) than in healthy individuals. According to the analysis of average values, the content of interleukin-6 in idiopathic hypothyroidism exceeded the level in health persons by 16.5 %. The content of total cholesterol in patients with hypothyroidism was 18.5 % higher than in apparently healthy individuals. Conclusions. The obtained data showed that persistence of proinflammatory states and dyslipidemia is one of the important factors of cardiovascular system lesion in patients with hypothyroidism. The proportion of people with aberrant levels of C-reactive protein, interleukin-6 and dyslipidemia is prevalent among patients with idiopathic hypothyroidism.

Article Details

How to Cite
Vernygorodskyi, V., N. Fetisova, and M. Vernygorodska. “Pathogenetic Significance of Proinflammatory Cytokines and Dyslipidemia in the Development of Cardiovascular Complications in Patients With Hypothyroidism”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 13, no. 4, July 2017, pp. 262-6, doi:10.22141/2224-0721.13.4.2017.106653.
Clinical Thyroidology


Zelinska NB. State of regional hemodynamics in patients with hypothyroidism. Klinichna endokrynologia ta endokrynna khirurgiya. 2009;1(26):3-8. (In Ukrainian).

Pankiv VI, author. Praktichna tireoїdologіja [Practical thyroidology]. Donetsk: Vidavec' Zaslavskyi; 2011. 224 p. (In Ukrainian).

Pankiv VI, Gavryliuk VM, Neporadna LD, et al. Intercommunications between thyroid structural and functional violations and components of metabolic syndrome. Mezhdunarodnyi Endokrinologicheskii Zhurnal. 2011;6(38):39-43. (In Ukrainian).

Katerynchuk VI, Katerynchuk IP. Cardiovascular pathology conditioned by hypothyroidism. Endokrynologiya. 2012;17(1):106-12. (In Ukrainian).

Mykhaylenko OYu, Zubkova SG. Structure and hemodynamics of carotid extracranial areas in patients with hypothyroidism. Endokrynologiya. 2012;17(1):32-6. (In Ukrainian).

Monrani F, Dardano A, Carraccio N. Does Treating Subclinical Hypothyroidism Improve Markers Cardiovascular Risk? Treat Endocrinol. 2006;5(2):65-81. PMID: 16542047.

Skrypnyk NV. Role of hypothyroidism in forming of insulin resistance. Klinichna endokrynologia ta endokrynna khirurgiya. 2009;4(29):47-53. (In Ukrainian).

Klimov AN, Nikulcheva YuG, authors. Obmen lipidov i lipoproteidov i ih narushenija [Lipid and lipoprotein metabolism and its disorders]. Sait-Petersburg; 1999. 505 s. (In Russian).

Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499-502. PMID: 4337382.