Dysfunction of the hypothalamus: etiology, clinical picture, diagnosis, treatment (guidelines)
Main Article Content
In the hypothalamus, there are nuclei of autonomic nervous system, as well endocrine system, and vitally important centers — of hunger, saturation, thermoregulation, sleep and wakefulness. Under the influence of traumatic brain injuries, neuroinfections and poisons, this complex integral system is often disturbed causing dysfunction of the hypothalamus. The prepared guidelines observe questions of the etiology, pathogenesis, clinical picture, diagnosis and treatment of hypothalamic dysfunction. In terms of therapy, a main emphasis is put on physiological approaches to the normalization of hypothalamic disorders. Particular attention is paid to the formulation of diagnosis according to the 10th revision of the International Statistical Classification of Diseases and Related Health Problems that has a significant importance for the regulation of statistical statements. Guidelines are intended for endocrinologists, neuropathologists, cardiologists, general practitioners and family doctors.
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Karachentsev YuI, editor. Ocherki klinicheskoj jendokrinologii [Essays of clinical endocrinology]. Kharkiv; 2011. 608 p. (In Russian).
Poline М, Glen V. Dokazatel'naja jendokrinologija [Evidential endocrinology]. Мoscow: GEOTAR-Media; 2008. 640 p. (In Russian).
Bodnar PM, editor. Endokrinologіja [Endocrinology]. Kyiv: Vyshcha Shkola; 2012. 460 p. (In Ukrainian)
Botsiurko VI, Bodnar PM, Mykhalchyshyn GP. Endokrinologіja u shemah і tablicjah [Endocrinology in charts and tables]. Ivano-Frankivsk; 2012. 117 p. (In Ukrainian).
Yron MC. Harrison Endocrinology. Hill Education; 2017. 633 p.
Shaikh MG. Hypothalamic dysfunction (hypothalamic syndromes). In: Oxford Textbook of Endocrinology and Diabetes. Wass JAH, Stewart PM, Amiel SA, Davies MC, editors. 2nd edition. doi: 10.1093/med/9780199235292.003.2181.
De Pontual L, Trochet D, Caillat-Zucman S, Abou Shenab OA, Bougneres P, Crow Y, Cunningham S, Esteva B, Heberle LC, Leger J, Pinto G, Polak M, Shafik MH, Straus C, Trang H, Munnich A, Lyonnet S, Desguerre I, Amiel J. Delineation of late onset hypoventilation associated with hypothalamic dysfunction syndrome. Pediatr Res. 2008;64(6):689-94. doi: 10.1203/PDR.0b013e318187dd0e.
Bougneres P, Pantalone L, Linglart A, Rothenbuhler A, Le Stunff C. Endocrine manifestations of the rapid-onset obesity with hypoventilation, hypothalamic, autonomic dysregulation, and neural tumor syndrome in childhood. J Clin Endocrinol Metabol. 2008;93(10):3971-80. doi: 10.1210/jc.2008-0238.
Ize-Ludlow D, Gray J, Sperling MA, Berry-Kravis EM, Milunsky JM, Farooqi IS, Rand CM, Weese-Mayer DE. Rapid onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation presenting in childhood. Pediatrics. 2007 Jul;120(1):e179-88. doi: 10.1542/peds.2006-3324.
Ezzat S, Asa SL, Couldwell WT, et al. The prevalence of pituitary adenomas: A systematic review. Cancer. 2004 Aug;101(3):613-9. doi: 10.1002/cncr.20412.
Casanueva FF, Molitch ME, Schlechte JA, et al. Guidelines of the pituitary society for the diagnosis and management of prolactinomas. Clin Endocrinol. 2006 Aug;65(2): 265-273. doi: 10.1111/j.1365-2265.2006.02562.x.
Krikorian A, Aron D. Evaluation and management of pituitary incidentalomas-revisiting an acquaintance. Nat Clin Pract Endocrinol Metab. 2006 Mar;2(3):138-45. doi: 10.1038/ncpendmet0122.