Peculiarities of disturbances of the functional renal state in the early period of experimental diabetes mellitus

Main Article Content

T.M. Boychuk
О.А. Olenovych
M.I. Grytsiuk
A.I. Gozhenko


Background. The purpose of our research was a comparative analysis of specificity and severity of kidney dysfunction in the early period of alloxan- and streptozotocin-induced diabetes mellitus. Materials and methods. The article presents data concerning the peculiarities of disturbances of the functional renal state on 11th day after the administration of diabetogenic dose of streptozotocin (70 mg/kg) and alloxan (160 mg/kg) in white non-linear matured male rats. Results. There were found common patterns in the development of renal disorders in the early period of streptozotocin- and alloxan-induced diabetes having, mainly, a functional origin in the absence of significant structural changes in the renal tubular apparatus. Conclusions. Disorders of nephron tubular system are not responsible for the changes in renal functions in the early period of experimental diabetes mellitus of both types.

Article Details

How to Cite
Boychuk, T., Olenovych О., M. Grytsiuk, and A. Gozhenko. “Peculiarities of Disturbances of the Functional Renal State in the Early Period of Experimental Diabetes Mellitus”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 13, no. 6, Oct. 2017, pp. 463-7, doi:10.22141/2224-0721.13.6.2017.112894.
Experimental Endocrinology


Bondar' IA, Klimentov VV. A role of glomerular cell dysfunction in the development of diabetic nephropathy. Problemi endokrinologii. 2006;52(4):45-9. (in Russian).

Galenova TI, Konopel'njuk VV, Savchuk OM, Ostapchenko LI. Reproduction of the streptozotocin-induced experimental model of type 2 diabetes mellitus in rats. Fizyka zhyvogo. 2010;18(3):50-4. (in Ukrainian).

Loboda OM, Dudar IO, Aljeksjejeva VV. Mechanisms of the development and progression of diabetic nephropathy. Klinichna imunologija. Alergologija. Infektologija. 2010;9-10(38-39):46-50. (in Ukrainian).

Majdannyk VG, Burlaka JeA. Molecular mechanisms of kidney damage in diabetes mellitus in children (literature review). Pediatrija, akusherstvo ta ginekologija. 2010;3:34-47. (in Ukrainian).

Merets'kyj VM. Peculiarities of free-radical lipid oxidation and antioxidant protection in renal and liver tissue in the experimental diabetes mellitus. Zdobutky klinichnoi' i eksperymental'noi' medycyny. 2012;1:96-8. (in Ukrainian).

Mozheyko LA. Experimental models for studying diabetes mellitus. Part 1. Alloxan diabetes. Journal of the Grodno State Medical University. 2013;3(43):26-9. (in Russian).

Rebrov BA. Kidney damage in diabetes mellitus. Mezhdunarodnyi Endokrinologicheskii Zhurnal. 2011;2(34):51-5. (in Russian).

Senatorova AS, Muratova EG. Features of renal function in children with diabetes mellitus in the kharkiv region. Medycyna s'ogodni i zavtra. 2012;2(55):76-80. (in Ukrainian).

Skrobons'ka NA, Cymbal TS. Diabetic nephropathy: some nontraditional factors of pathogenesis, basic directions of diagnosis and treatment (literature review and own data). Simejna medycyna. 2011;4:18-22. (in Ukrainian).

Khutorska LA. Prevalence, absolute and relative risk of diabetic nephropathy in patients with diabetes mellitus. Buk Med Herald. 2012;16(4):170-5. (in Ukrainian).

Shulyarenko LV. Chronic diabetic renal disease: the contemporary view on the problem. Endokrynologia. 2013;18(1):73-82. (in Ukrainian).

Dranovalli S, Duka I, Bakris GL. The pathogenesis of diabetic nephropathy. Nat Clin Pract Endocrinol Metab. 2008 Aug;4(8):444-52. doi: 10.1038/ncpendmet0894.

Evans TC, Capell P. Diabetic nephropathy. Clin Diabetes 2000;18(1). Available from: Accessed: 22 May 2011.

Forst T, Kunt T, Wilhelm B, Weber MM, Pfützner A. Role of C-Peptide in the regulation of microvascular blood flow. Exp Diabetes Res. 2008; 2008: 176245. doi: 10.1155/2008/176245.

Zhang М, Feng L, Gu J, et al.The attenuation of moutan cortex on oxidative stress for renal injury in AGEs-induced mesangial cell dysfunction and streptozotocin-induced diabetic nephropathy rats. Oxidative medicine and cellular longevity. 2014;18:1-13. doi: 10.1155/2014/463815.

Most read articles by the same author(s)