Influence of diffuse nontoxic goiter on placental insufficiency, course of gestation and childbirth
Main Article Content
Abstract
Background. There are significant disorders in the functioning of the mother-placenta-fetus system in women with thyroid pathology, especially in chronic iodine deficiency. This leads to complications of pregnancy, childbirth with a threat to the newborn’s health. The purpose of the study was to investigate the effect of potassium iodide in combination with sodium selenite and cytoflavin in women with diffuse nontoxic goiter for the correction of disorders in the mother-placenta-fetus during pregnancy. Materials and methods. To assess the state of pregnancies in the period from 2012 to 2017, 159 pregnant women and their newborns, who formed two groups, were examined. The first group consisted of 79 pregnant women with diffuse nontoxic goiter, who did not receive potassium iodide and other drugs for various reasons. The second group was formed by 80 women, who received potassium iodide (200 μg/day) in combination with sodium selenite and cytoflavin. Results. Chronic fetoplacental insufficiency is registered in 21.1 % of cases, with a significant difference in its incidence in two groups of women surveyed: 27.9 % in group I and 14.3 % in group II. The level of thyroid-stimulating hormone in children born from women in the first and second groups did not differ significantly and did not exceed the normal values (4.72 ± 1.22 mIU/l and 2.73 ± 1.01 mIU/l, respectively). The concentration of thyroid-stimulating hormone in the blood of infants of the second group was 42.2 % lower than in the newborns of the first group. Conclusions. The beneficial effect of taking potassium iodide in combination with sodium selenite and cytoflavin during gestation on the development of the fetus reveals itself by a statistically significant reduction in the incidence of intrauterine complications in group II compared with group I of the study: chronic fetoplacental insufficiency (14.3 and 27.9 %, respectively; p < 0.05) and chronic fetal hypotrophy (13.8 and 28.6 %, respectively, p < 0.05).
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
References