Роль генетичних чинників у розвитку діабетичної дистальної симетричної полінейропатії (огляд літератури та власні дослідження)

I.А. Zoriy; N.V. Pashkovska

doi:10.22141/2224-0721.14.4.2018.140196

DOI: https://doi.org/10.22141/2224-0721.14.4.2018.140196

Keywords:

diabetes mellitus type 2, distal symmetric polyneuropathy, genetic factors, endothelial nitric oxide synthase gene G894T polymorphism, review

I.А. Zoriy

State Higher Education Institution of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine

N.V. Pashkovska

State Higher Education Institution of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine

Abstract

The article presents data of the literature review and own observations on studying the role of genetic factors in the risk of development and progression of severe complications of diabetic distal symmetric polyneuropathy. It was found that in patients with non-insulin-dependent (type 2) diabetes mellitus complicated by distal symmetric polyneuropathy, there is an association between the homozygous ТТ genotype of endothelial nitric oxide synthase gene G894T polymorphism and significant subjective symptoms, the presence of axonal lesion of motor nerves according to electroneuromyography, with an increase in the level of glycated hemoglobin, and also in the content of lipid peroxidation products.

How to Cite

Zoriy, I., and N. Pashkovska. “Role of Genetic Factors in the Development of Diabetic Distal Symmetric Polyneuropathy (review of Literature and Own Researches)”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 14, no. 4, Aug. 2018, pp. 395-01, doi:10.22141/2224-0721.14.4.2018.140196.

Issue

Vol. 14 No. 4 (2018)

Section

Literature Review

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