Vitamin D as an independent predictor of obesity in adolescents
Main Article Content
Background. Today, there is evidence that a low level of vitamin D can be considered as an independent predictor for the formation and progression of obesity. Objective: to study the levels of vitamin D in the blood of children with overweight and obesity. Materials and methods. A group of adolescents (15–18 years) with overweight and obesity was formed from 55 people included in a study group. The comparison group consisted of 20 apparently healthy adolescents of the same age. Methods of examination included anamnesis collection, anthropometry, determination of 25(OH)D content in the blood plasma, total cholesterol, triglycerides, high and low density lipoproteins, calcium, phosphorus, alkaline phosphatase. The statistical processing of the data was carried out in the Excel 2003 environment for Windows XP. Results. Median 25(OH)D in the control group was 21.67 ng/ml (confidence interval (CI): 16.06–28.85). The content of 25(OH)D was normal in 16 (80 %) persons, in 3 (15 %) patients, the level of 25(OH)D indicated vitamin D insufficiency, and in 1 (5 %) child, vitamin D deficiency was detected. The analysis of 25(OH)D in the group of adolescents with overweight showed its deficiency in 6 persons (26.1 %), insufficiency — in 14 (60.8 %) and normal provision — in 3 (13 %), with a median of 18.29 ng/ml (CI: 16.6–20.1). Median of 25(OH)D in the group of overweight adolescents was 16.15 ng/ml (CI: 12.7–23.8). Normal content of 25(OH)D was determined only in 2 (6.2 %) persons, deficiency was detected in 17 (53.1 %), insufficiency — in 13 patients (40.6 %). Vitamin D deficiency in obese children is associated with dyslipidemia due to reduced low-atherogenic lipid fractions. Analysis of the relationship between serum concentration of 25(OH)D and indices of total calcium, phosphorus and alkaline phosphatase did not reveal a significant correlation. Conclusions. Adolescents with obesity and overweight have a decrease in 25(OH)D (deficiency or insufficiency), dyslipidemia due to reduced low-atherogenic and increased high-atherogenic lipid fractions, and the preservation of traditional phosphorus-calcium metabolism indices within the reference values.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
Van Grouw JM, Volpe SL. Childhood obesity in America. Curr Opin Endocrinol Diabetes Obes. 2013;20(5):396-400. doi: 10.1097/01.med.0000433064.78799.0c.
Ke L, Mason RS, Baur LA, et al. Vitamin D levels in childhood and adolescence and cardiovascular risk factors in a cohort of healthy Australian children. J Steroid Biochem Mol Biol. 2018;177:270-277. doi: 10.1016/j.jsbmb.2017.07.010.
Pankiv IV. Effect of vitamin D supplementation on insulin resistance in patients with hypothyroidism. Mìžnarodnij endokrinologìčnij žurnal. 2017;13(6):455-458. doi: 10.22141/2224-07126.96.36.1997.112892.
Tatarchuk TF, Bulavenko OV, Kapshuk IM, Ternopolska VO. Vitamin D deficiency in the genesis of reproductive health disorders. Ukrayinskyj medychnyj chasopys. 2015;(109):56-59. (in Ukrainian).
Nykytyna YL, Todyeva AM, Karonova TL, Gryneva EN. To the issue of metabolic disorders in children with a reduced level of vitamin D and obesity. Lechaschi Vrach. 2014,14(3):10-17. (in Russian).
Mallet E. We thought everything had been said about vitamin D, but deficiency still exists and it is not only bone effects. Arch Pediatr. 2010;17(6):810-811. doi: 10.1016/S0929-693X(10)70123-8. (in French).
Holick MF. The D-lightful vitamin D for child health. JPEN J Parenter Enteral Nutr. 2012 Jan;36(1 Suppl):9S-19S. doi: 10.1177/0148607111430189.
Pludowski P, Karczmarewicz E, Bayer M, et al. Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe – recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynol Pol. 2013;64(4):319-327.
Vidailhet M, Garabédian M. Vitamin D requirements for French children. Arch Pediatr. 2010;17(6):808-9. doi: 10.1016/S0929-693X(10)70122-6. (in French).
Colapinto CK, Rossiter M, Khan MK, Kirk SF, Veugelers PJ. Obesity, lifestyle and socio-economic determinants of vitamin D intake: a population-based study of Canadian children. Can J Public Health. 2014;105(6):e418-24.
Shilin DE. Vitamin D hormone in the 21st century clinic: pleiotropic effects and laboratory evaluation (a lecture). Klinicheskaya Laboratornaya Diagnostika. 2010;(12):17-23. (in Russian).
Cediel G, Corvalán C, López de Romaña D, Mericq V, Uauy R. Prepubertal adiposity, vitamin D status, and insulin resistance. Pediatrics. 2016;138(1). pii: e20160076. doi: 10.1542/peds.2016-0076.
Motlaghzadeh Y, Sayarifard F, Allahverdi B, et al. Assessment of vitamin D status and response to vitamin D3 in obese and non-obese Iranian children. J Trop Pediatr. 2016;62(4):269-75. doi: 10.1093/tropej/fmv091.
Munasinghe LL, Willows N, Yuan Y, Veugelers PJ. The prevalence and determinants of use of vitamin D supplements among children in Alberta, Canada: a cross-sectional study. BMC Public Health. 2015;15:1063. doi: 10.1186/s12889-015-2404-z.
Rosen CJ, Abrams SA, Aloia JF, et al. IOM committee members respond to Endocrine Society vitamin D guideline. J Clin Endocrinol Metab. 2012;97(4):1146-52. doi: 10.1210/jc.2011-2218.
Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385.