Vitamin D status, frequency of its insufficiency and deficiency in women with polycystic ovary syndrome

Article Sidebar

PDF (Українська)
DOI: https://doi.org/10.22141/2224-0721.14.6.2018.146069
Keywords:
vitamin D, polycystic ovary syndrome

Main Article Content

I.V. Pankiv
State Higher Education Institution of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine
https://orcid.org/0000-0001-5576-636X
O.O. Korytko
Danylo Halytskyi Lviv National Medical University, Lviv, Ukraine

Abstract

Background. Many studies have investigated vitamin D status in women with polycystic ovary syndrome (PCOS), but there is no consensus on whether or not its serum levels are different between women with and without PCOS. Current evidence suggests an inverse association between vitamin D status and metabolic disturbances in PCOS. No studies have been conducted to evaluate vitamin D level in the blood serum of Ukrainian women with PCOS. Purpose of the study was to determine vitamin D level in the blood serum, and also the prevalence of its insufficiency and deficiency in women with PCOS as compared to the healthy women. Materials and methods. Forty five PCOS women and body mass index­ and age­matched 25 healthy controls were recruited in observational, cross­sectional study. Serum vitamin D concentrations less than 30 ng/ml were classified as insufficiency and vitamin D deficiency — with a concentration below 20 ng/ml. Correlations between metabolic parameters and vitamin D status were analyzed separately in patients and controls. Results. Significant differences were observed in serum vitamin D levels, as well as in the prevalence of its insufficiency and deficiency between patients with PCOS and healthy women (93.3 and 84.0 %, respectively). In PCOS women, we found significantly negative correlations of vitamin D levels with body mass index and dehydroepiandrosterone sulfate serum concentrations. Conclusions. We found differences in the absolute level of serum vitamin D and the prevalence of its deficiency in PCOS and healthy women, suggesting a specific role of vitamin D in the pathogenesis of PCOS. Since vitamin D deficiency prevalence is high, large intervention trials are needed to evaluate the effect of vitamin D supplementation in PCOS women.

Article Details

How to Cite
Pankiv, I., and O. Korytko. “Vitamin D Status, Frequency of Its Insufficiency and Deficiency in Women With Polycystic Ovary Syndrome”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 14, no. 6, Nov. 2018, pp. 585-9, doi:10.22141/2224-0721.14.6.2018.146069.
Issue
Vol. 14 No. 6 (2018)
Section
Original Researches
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Our edition uses the copyright terms of Creative Commons for open access journals.

Authors, who are published in this journal, agree with the following terms:

  1. The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
  2. Directing  the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
  3. The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
  4. The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
  5. The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
  6. The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.

References

Hossein-nezhad A, Holick MF. Vitamin D for health: A global perspective. Mayo Clin Proc. 2013 Jul;88(7):720-55. doi: 10.1016/j.mayocp.2013.05.011.

Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385.

Kienreich K, Tomaschitz A, Verheyen N. Vitamin D and cardiovascular disease. Nutrients. 2013 Jul 31;5(8):3005-21. doi: 10.3390/nu5083005.

Karras SN, Wagner CL, Castracane VD. Understanding vitamin D metabolism in pregnancy: From physiology to pathophysiology and clinical outcomes. Metabolism. 2018 Sep;86:112-123. doi: 10.1016/j.metabol.2017.10.001.

Dawodu A, Akinbi H. Vitamin D nutrition in pregnancy: Current opinion. Int J Womens Health. 2013 Jun 24;5:333-43. doi: 10.2147/IJWH.S34032.

Mulligan ML, Felton SK, Riek AE, Bernal-Mizrachi C. Implications of vitamin D deficiency in pregnancy and lactation. Am J Obstet Gynecol. 2010 May;202(5):429.e1-9. doi: 10.1016/j.ajog.2009.09.002.

Novakovic B, Sibson M, Ng HK, et al. Placenta-specific methylation of the vitamin D 24-hydroxylase gene: Implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface. J Biol Chem. 2009 May 29;284(22):14838-48. doi: 10.1074/jbc.M809542200.

Wagner CL, Taylor SN, Dawodu A, Johnson DD, Hollis BW. Vitamin D and its role during pregnancy in attaining optimal health of mother and fetus. Nutrients. 2012 Mar;4(3):208-30. doi: 10.3390/nu4030208.

Hossein-nezhad A, Holick MF. Vitamin D for health: A global perspective. Mayo Clin Proc. 2013 Jul;88(7):720-55. doi: 10.1016/j.mayocp.2013.05.011.

Heyden EL, Wimalawansa SJ. Vitamin D: Effects on human reproduction, pregnancy, and fetal well-being. J Steroid Biochem Mol Biol. 2018 Jun;180:41-50. doi: 10.1016/j.jsbmb.2017.12.011.

Płudowski P, Karczmarewicz E, Bayer M, et al. Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe – Recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynol Pol. 2013;64(4):319-27.

Wagner CL, Taylor SN, Dawodu A, Johnson DD, Hollis BW. Vitamin D and its role during pregnancy in attaining optimal health of mother and fetus. Nutrients. 2012 Mar;4(3):208-30. doi: 10.3390/nu4030208.

Hollis BW, Wagner CL. Vitamin D and pregnancy: Skeletal effects, nonskeletal effects, and birth outcomes. Calcif Tissue Int. 2013 Feb;92(2):128-39. doi: 10.1007/s00223-012-9607-4.

Rostami M, Tehrani FR, Simbar M, et al. Effectiveness of prenatal vitamin D deficiency screening and treatment program: A stratified randomized field trial. J Clin Endocrinol Metab. 2018 Aug 1;103(8):2936-2948. doi: 10.1210/jc.2018-00109.

Palacios C, De-Regil LM, Lombardo LK, Peña-Rosas JP. Vitamin D supplementation during pregnancy: Updated meta-analysis on maternal outcomes. J Steroid Biochem Mol Biol. 2016 Nov;164:148-155. doi: 10.1016/j.jsbmb.2016.02.008.

De-Regil LM, Palacios C, Lombardo LK, Peña-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev. 2016 Jan 14;(1):CD008873. doi: 10.1002/14651858.CD008873.pub3.

Wehr E, Trummer O, Giuliani A, Gruber HJ, Pieber TR, Obermayer-Pietsch B. Vitamin D-associated polymorphisms are related to insulin resistance and vitamin D deficiency in polycystic ovary syndrome. Eur J Endocrinol. 2011 May;164(5):741-9. doi: 10.1530/EJE-11-0134.

Panidis D, Balaris C, Farmakiotis D, et al. Serum parathyroid hormone concentrations are increased in women with polycystic ovary syndrome. Clin Chem. 2005 Sep;51(9):1691-7. doi: 10.1373/clinchem.2005.052761.

Tatarchuk TF, Bulavenko OV, Kapshuk IM, Tarnopol's'ka VO. Vitamin D insufficiency in genesis of reproductive health disorders. Ukrainian medical journal. 2015;(109):56-60. (in Ukrainian).

Hilger J, Friedel A, Herr R, et al. A systematic review of vitamin D status in populations worldwide. Br J Nutr. 2014 Jan 14;111(1):23-45. doi: 10.1017/S0007114513001840.

Pereira-Santos M, Costa PR, Assis AM, Santos CA, Santos DB. Obesity and vitamin D deficiency: a systematic review and metaanalysis. Obes Rev. 2015 Apr;16(4):341-9. doi: 10.1111/obr.12239.

Haymana C, Sonmez A, Aydogdu A, et al. Effect of testosterone replacement therapy on vitamin D and FGF-23 levels in congenital hypogonadism. Endokrynol Pol. 2017;68(3):311-616. doi: 10.5603/EP.a2017.0009.

Yildizhan R, Kurdoglu M, Adali E, et al. Serum 25-hydroxyvitamin D concentrations in obese and non-obese women with polycystic ovary syndrome. Arch Gynecol Obstet. 2009 Oct;280(4):559-63. doi: 10.1007/s00404-009-0958-7.

Most read articles by the same author(s)

1 2 3 4 > >>