The probability of the influence of professional chemical factors on the development of hypothyroidism and other lesions of the human body

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A.I. Voloshin
T.A. Ilashchuk
L.A. Voloshina
I.V. Pankiv
V.S. Yuzvenko


Background. The purpose is to present clinical observations of diseases of workers in individual industries, where a priori there was an effect of various production chemical factors that caused damage to the cardiovascular system such as coronary heart disease with impaired heart rhythm, and hypothyroidism. Mate­rials and methods. A total of 11 sick women aged 53–62 years who worked in the intensive gardening enterprises (n = 6), workshops for sewing synthetic clothes (n = 3) and the production of synthetic wreaths (n = 2) underwent comprehensive examination. Results. Torpid manifestations of coronary heart disease with frequent extrasystoles and episodes of atrial fibrillation, heart failure of the second functional class and signs of hypothyroidism that in overt according to clinical data, but subclinical in terms of thyroid-sti­mulating hormone and thyroid hormone levels, as well as symptoms of steatohepatosis, chronic acalculous hypokinetic gallbladder di­sease and irritable bowel syndrome were detected. The consensus (cardiologist, gastroenterologist, endocrinologist) analyzed the possible causes for the low results of the modern approaches to comprehensive treatment, as well as the inappropriateness of the use of levothyroxine and amiodarone. As an alternative, patients additionally took multicomponent thyroid-stabilizing phytotherapy (Potentilla alba L., 80 mg, Filipendula vulgaris Moench., 30 mg, Genista tinctoria, 10 mg, Paeonia anomala, 30 mg, Gemmae betulae, 50 mg, Arthrospira, 40 mg, Corylus, 40 mg). A significant improvement was achieved in the treatment results in the cardiological, gastroenterological and endocrinological aspects. Conclusions. In modern conditions of insufficient sanitary surveillance in certain industries, possible chronic production poisonings by chemical factors with various mechanisms of systemic action, in particular with thyroid gland damage, causes the torpid course of diseases and a decrease in the results of using modern treatment approaches. A careful professional history, pathogenetic assessment of the clinical situation and the use of phytotherapy can improve the overall treatment results.

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How to Cite
Voloshin, A., T. Ilashchuk, L. Voloshina, I. Pankiv, and V. Yuzvenko. “The Probability of the Influence of Professional Chemical Factors on the Development of Hypothyroidism and Other Lesions of the Human Body”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 16, no. 3, Apr. 2020, pp. 227-30, doi:10.22141/2224-0721.16.3.2020.205271.
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