Pathophysiological and clinical aspects of interaction between coronavirus disease 2019 and thyroid

Main Article Content

V.I. Pankiv
N.V. Pashkovska
I.V. Pankiv
V.A. Maslyanko
I.O. Tsaryk


In patients who were not previously diagnosed with any thyroid conditions, the scenario of COVID-19 related anomalies of the thyroid may include either: a process of central thyroid-stimulating hormone disturbances via virus‑related hypophysitis; an atypical type of subacute thyroiditis which is connected to the virus spread or to excessive cytokine production including a destructive process with irreversible damage to the gland or low triiodothyronine syndrome (non-thyroidal illness syndrome) which is not specifically related to the COVID‑19 infection, but which is associated with a very severe illness status. This review aimed to investigate thyroid changes resulted from the COVID-19 infection. Ongoing assessment of the effects of the COVID-19 pandemic will reveal more information on coronavirus-induced thyroid conditions. Routine thyroid assays performed in patients with severe infection/acute phase of COVID-19 are encouraged to detect thyrotoxicosis. After recovery, thyroid function should be assessed to identify potential hypothyroidism. There remain unanswered questions related to the predictive value of interleukin-6 in infected patients, especially in cases of cytokine storm, and the necessity of thyroid hormone replacement in subjects with hypophysitis-related central hypothyroidism.

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How to Cite
Pankiv, V., N. Pashkovska, I. Pankiv, V. Maslyanko, and I. Tsaryk. “Pathophysiological and Clinical Aspects of Interaction Between Coronavirus Disease 2019 and Thyroid”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 17, no. 4, Sept. 2021, pp. 329-33, doi:10.22141/2224-0721.17.4.2021.237348.
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