The effect of iodine deficiency on the course of recurrent respiratory infection in children living in the iodine deficient region

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T.V. Sorokman
O.V. Makarova


Background. The consequence of iodine deficiency is a decrease in the secretion of thyroid hormones, which adversely affects the immune system with the development of somatic and predisposition to frequent respiratory diseases. The purpose was to investigate the iodine supply of the body of children with recurrent respiratory infections (RRI) by studying the organification and inorganic fractions of iodine in the serum and excretion of iodine in the urine. Materials and methods. The study was conducted by simple sampling, taking into account the characteristics of the clinic course of respiratory disease. Clinical and laboratory and instrumental examination was performed in 60 children aged 3 to 11 years with a diagnosis of RRI. The concentration of iodine in urine, the level of inorganic and organification iodine in the blood were studied. Results. The clinical picture presented with the symptoms of intoxication, fever, and catarrhal symptoms typical of RRI. In children with severe RRI experienced a clear decrease in the iodine level to 57.34 μg/l (p < 0.05) and a decline in the blood content of total iodine and iodine organification by 31.12 and 39.11 % (p < 0.001), respectively. The concentration of inorganic iodine was significantly higher (p < 0.001). Such results indicate a “wrong” subcellular distribution of iodine into fractions in the inflammatory process caused by RRI. The children with detected iodine deficiency demonstrated a more severe course of RRI. There was a moderately negative relationship between the levels of organification and inorganic iodine (r = –0.515; p < 0.05) and a direct relationship between the blood concentrations of total and organification iodine (r = 0.899; p < 0.05). Conclusions. The course of RRI in patients with iodine deficiency is characterized by an increase in the level of inorganic iodine, a decrease in organification iodine and total iodine, the deepening of these changes correlates with the severity of the respiratory disease.

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How to Cite
Sorokman, T., and O. Makarova. “The Effect of Iodine Deficiency on the Course of Recurrent Respiratory Infection in Children Living in the Iodine Deficient Region”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 17, no. 5, Oct. 2021, pp. 448-52, doi:10.22141/2224-0721.17.5.2021.241527.
Original Researches


Van Meel ER, den Dekker HT, Elbert NJ, et al. A population-based prospective cohort study examining the influence of early-life respiratory tract infections on school-age lung function and asthma. Thorax. 2018 Feb;73(2):167-173. doi:10.1136/thoraxjnl-2017-210149.

El-Azami-El-Idrissi M, Lakhdar-Idrissi M, Chaouki S, Atmani S, Bouharrou A, Hida M. Pediatric recurrent respiratory tract infections: when and how to explore the immune system? (About 53 cases). Pan Afr Med J. 2016 May 12;24:53. doi:10.11604/pamj.2016.24.53.3481.

Li Y, Fu X, Ma J, et al. Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children. Nat Commun. 2019 May 23;10(1):2288. doi:10.1038/s41467-019-10294-x.

Pecora F, Persico F, Argentiero A, Neglia C, Esposito S. The Role of Micronutrients in Support of the Immune Response against Viral Infections. Nutrients. 2020 Oct 20;12(10):3198. doi:10.3390/nu12103198.

Kravchenko VI, Medvedev BK. The biological role of iodine and iodine deficiency as pathogenetic factor of thyroid pathology in pregnant women and its prevention. Mìžnarodnij endokrinologìčnij žurnal. 2018;14(2):111-118. doi:10.22141/2224-0721.14.2.2018.130552. (in Ukrainian).

Verheesen RH, Traksel RAM. Iodine, a preventive and curative agent in the COVID-19 pandemic? Med Hypotheses. 2020 Nov;144:109860. doi:10.1016/j.mehy.2020.109860.

Iannaccone M, Ianni A, Elgendy R, et al. Iodine Supplemented Diet Positively Affect Immune Response and Dairy Product Quality in Fresian Cow. Animals (Basel). 2019 Oct 25;9(11):866. doi:10.3390/ani9110866.

Bilal MY, Dambaeva S, Kwak-Kim J, Gilman-Sachs A, Beaman KD. A Role for Iodide and Thyroglobulin in Modulating the Function of Human Immune Cells. Front Immunol. 2017 Nov 15;8:1573. doi:10.3389/fimmu.2017.01573.

Sorokman TV, Bachu MI. Social and hygienic characteristics of children from the iodine deficiency region. Mìžnarodnij endokrinologìčnij žurnal. 2021;17(1):111-116. doi:10.22141/2224-0721.17.1.2021.226438. (in Ukrainian).

Júnior DST. Environmental and individual factors associated with protection and predisposition to autoimmune diseases. Int J Health Sci (Qassim). 2020 Nov-Dec;14(6):13-23.

Ministry of Нealth of Ukraine. Order on July 16, 2014 № 499. On Adoption and Implementation of Medical and Technological Documents on the Standardization of Medical Care for Influenza and Acute Respiratory Infections. Available from: Accessed: July 16, 2014. (in Ukrainian).

Arbuzova MI, Makhmudov AA, Gerasimov GA, Ilyin AV. Micromethod of iodine measurement in vrine. Klinicheskaia i eksperimentalnaia tiroidologia. 2007;3(2):15-18. doi:10.14341/ket20073215-18. (in Russian).

Shidlovsky OV, Falfushynska HI, Osadchuk DV, Stolyar OB, Shidlovsky VO. Sposib vyznachennja koncentracii' jodu v biosubstrati [Method for determining the concentration of iodine in a biosubstrate]. Patent UA № 45332 U, 2009. (in Ukrainian).

Koukkou EG, Roupas ND, Markou KB. Effect of excess iodine intake on thyroid on human health. Minerva Med. 2017 Apr;108(2):136-146. doi:10.23736/S0026-4806.17.04923-0.

Boelen A, Kwakkel J, Fliers E. Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection. Endocr Rev. 2011 Oct;32(5):670-693. doi:10.1210/er.2011-0007.

Zimmermann MB, Boelaert K. Iodine deficiency and thyroid disorders. Lancet Diabetes Endocrinol. 2015 Apr;3(4):286-295. doi:10.1016/S2213-8587(14)70225-6.

Walther B, Wechsler D, Schlegel P, Haldimann M. Iodine in Swiss milk depending on production (conventional versus organic) and on processing (raw versus UHT) and the contribution of milk to the human iodine supply. J Trace Elem Med Biol. 2018 Mar;46:138-143. doi:10.1016/j.jtemb.2017.12.004.

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