Ultrasound Densitometry in the Diagnosis of Disorders of Bone Mineral Density in Patients with Thyroid Pathology
Main Article Content
The objective of this study was to establish the relationship between the levels of thyroid hormones and characteristics of bone tissue according to radiological and laboratory methods. To assess the influence of thyroid hormone levels on the bone tissue, there was performed a comparative study of four groups of patients aged 19 to 49 years. The main study groups consisted of 34 patients with diffuse toxic goiter (DTG) and 42 patients with overt primary hypothyroidism. A comparison group included 23 patients with diffuse nontoxic goiter and preserved functional state of the thyroid gland (indicators of thyroid-stimulating hormone (TSH) and fT4 were not statistically significantly different from the control group data). The control group is presented by 20 apparently healthy persons. It was found that excessive production of thyroid hormone with a pronounced inhibition of TSH (0.08 ± 0.03 µIU/ml) in patients with DTG, as well as reduced thyroid function with higher levels of TSH (8.24 ± 3.16 µIU/ml) in patients with overt hypothyroidism, lead to disturbances in the system of bone metabolism: in thyrotoxicosis — increase with the predominance of resorption, and in hypothyroidism — decrease of bone remodeling. Ultrasonic densitometry has shown a statistically significant decrease of bone density values and increased incidence of osteopenia and osteoporosis compared to apparently healthy individuals. The development of hyperthyroidism in the age under 30 increases the risk of osteopenic syndrome in patients with DTG. The incidence of osteopenic syndrome in patients with overt hypothyroidism does not depend on age.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
Кравченко В.І., Постол С.В. Динаміка захворюваності на патологію щитоподібної залози в Україні // Міжнародний ендокринологічний журнал. — 2011. — № 3 (35). —
Korelitz J.J., McNally D.L., Masters M.N. et al. Prevalence of thyrotoxicosis, antithyroid medication use, and complications among pregnant women in the United States // Thyroid. — 2013. — Vol. 23 (6). — P. 758-765. doi: 10.1089/thy.2012.0488.
Hollowell J.G., Staehling N.W. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994) National Health and Nutrition Examination Survey (NHANES-II) // J. Clin. Endocrinol. Metabol. — 2002. — Vol. 87. — P. 489-499.
Балаболкин М.И. Фундаментальная и клиническая тироидология / Балаболкин М.И., Клебанова Е.М., Креминская В.М. — М.: Медицина, 2007. — 816 с.
González-Rodríguez L.A. Thyroid dysfunction in an adult female population: A population-based study of Latin American Vertebral Osteoporosis Study (LAVOS) / L.A. González-Rodríguez, M.E. Felici-Giovanini, L. Haddock // P.R. Health Sci. J. — 2013. — Vol. 32. — P. 57-62.
The association between serum thyrotropin levels and bone mineral density in healthy euthyroid men / B.J. Kim, S.H. Lee, S.J. Bae [et al.] // Clin. Endocrinol. — 2010. — Vol. 73 (3). — P. 396-403.
The relationship between serum TSH and bone mineral density in men and postmenopausal women: the Tromsø study / G. Grimnes, N. Emaus, R.M. Joakimsen [et al.] // Thyroid. — 2008. — Vol. 18. — P. 1147-1155.
Thyroid function and bone mineral density among Indian subjects / R.K. Marwaha, M.K. Garg, N. Tandon [et al.] // Indian J. Endocrinol. Metab. — 2012. — Vol. 16. — P. 575-579.
Поворознюк В.В. Захворювання кістково-м’язової системи в людей різного віку (вибрані лекції, огляди, статті): У 3 т. / Поворознюк В.В. — Т. 3. — К., 2009. — 664 с.
Girgis C.M., Champion B.L., Wall J.R. Current concepts in Grave’s disease // Ther. Adv. Endocrinol. Metab. — 2011. — Vol. 2 (3). — P. 135-144.