Features of lymphocyte phenotyping in patients with activated recurrent herpetic infection of the first/second type and reproductive system disorders

Article Sidebar

PDF (Українська)
DOI: https://doi.org/10.22141/2224-0721.13.1.2017.96759
Keywords:
herpes simplex, relapse, infertility

Main Article Content

T.V. Shmyga
Danylo Halytskyi Lviv National Medical University, Lviv, Ukraine
V.Yu. Gayevska
Danylo Halytskyi Lviv National Medical University, Lviv, Ukraine
V.Yu. Gayevskyi
Danylo Halytskyi Lviv National Medical University, Lviv, Ukraine

Abstract

The aim of the study was an analysis of the features of changes in lymphocyte subpopulation according to the data of immunography in patients with a recrudescent herpetic infection and reproductive violations. Materials and methods. The peculiarities of lymphocyte phenotyping were studied in 120 patients with activated recurrent herpetic infection of the first/second type (herpes simplex virus (HSV) 1/2), among whom 63 patients were diagnosed with infertility. Results. An increase in the level of killer cells was detected: CD16+/56+ (NK-cells) — in moderately recurrent infection (1–5 relapses within one year) and CD3+/8+ (T-suppressor/killer cells) — in frequently recurrent infection (6 or more episodes during the year). Conclusions. In infertile patients with recurrent HSV 1/2 infection, there has been observed a deficit of cells with suppressive activity: CD4+CD25+CD127– (regulatory T-cells) lymphocytes and CD3+/8+ (T-suppressor/killer cells) lymphocytes.

Article Details

How to Cite
Shmyga, T., V. Gayevska, and V. Gayevskyi. “Features of Lymphocyte Phenotyping in Patients With Activated Recurrent Herpetic Infection of the first/Second Type and Reproductive System Disorders”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), vol. 13, no. 1, Feb. 2017, pp. 61-65, doi:10.22141/2224-0721.13.1.2017.96759.
Issue
Vol. 13 No. 1 (2017)
Section
Original Researches
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Our edition uses the copyright terms of Creative Commons for open access journals.

Authors, who are published in this journal, agree with the following terms:

  1. The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
  2. Directing  the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
  3. The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
  4. The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
  5. The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
  6. The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.

References

Ambalov M, Ryazanov A, Kovalenko AP. Method of design of relapses of disease in patients by a simple herpes and its nosotropic ground. Cytokines and Inflammation. 2012;11(3):52-53 (Russian).

Bondarev LS, Zaplotnaya AA, Sotnik YP. Herpes and viral infection — a modern look to the problem. Vestnik neotlozhnoy i vosstanovytelnoy mediciny. 2006;7(3):473-478 (Russian).

Hlants C. Meditsinskaia i biologicheskaia statistika [Medical and biological statistics]. Moskow: Practice; 1998. 459 p. (Russian).

Drannyk GN, Svydro EV. Infections caused by herpes simplex virus. Zdorov’ja Ukrai’ny. 2007;2, 24-25 (Russian).

Zheleznyakova GF. Regulator Т-lymphocytes in immune answer for an infection. Zhurnal ynfektolohy. 2011;3(1):6-12 (Russian).

Zlotnykova MV. Mechanisms of natural and adaptive immunity at the infections caused by the viruses of simple herpes 1 and 2 types. Problemy zdorov’ia i ekologii. 2014;1:7-14 (Russian).

Servetskyy L, Shepherd T, Oliynyk AG, Nikitin AE. Changes in indicators of cellular immunity in patients with herpes infection. Materials of VIII Ukrainian congress of infectious disease. Vinnytsia, 2010; 107 s. (Ukrainian).

Mardanly SG, Kirpichnikova GI, Neverov VA. Herpetic infection (Simple herpes). Elektrohorsk: ZAO EKOlab, 2010; 56 s. (Russian).

Naumenko VA, Bush AA. Herpes virus and masculine sterility: is there connection? Voprosy virusologii. 2013;58(3):4-9 (Russian).

Rebrov O. Statystical analysis of medical results. Application of package program STATISTICA. M.: Medyasfera, 2002; 312 s. (Russian).

Selyutyn A, Selkov SA. Methods of determination of maintenance of Т-regulatory cages in peripheral blood. Terra medica. 2008;4:19-21 (Russian).

Freydlin IS. Immune system and antiviral immunities, questions of the general virology. SPb: SPbGMA of I. Mechnikov, 2007; 65-129 (Russian).

Cherkasov V. Herpetic infection: clinical and immunologic and psychosomatic features. Ukrains’kyj medychnyj al’manah. 2011;14(1):221-223 (Ukrainian).

Monavari SH, Vaziri MS, Khalili M. et al. Asymptomatic seminal infection of herpes simplex virus: impact on male infertility. J Biomed Res. 2013;27(1):56-61.

Forbes LR, Paessler M, Orange JS. CD16 deficiency discovered in a cohort of patients with severe herpesviral infections using a new diagnostic test. J Allergy Clin Immunol. 2009;123(2):67.

Grinde B. Herpesviruses: latency and reactivation — viral strategies and host response. J Oral Microbiol. 2013;5:4-10.

Su H, Longhi MS, Wang P. Human CD4+CD25(high)CD127 (low/neg) regulatory T cells. Methods Mol Biol. 2012;806:287-299.

Retamal-Díaz AR, Suazo PA, Garrido I et al. Immune evasion by herpes simplex virus. Rev Chil Infectol. 2015;32(1):58-71.

Bennett JM, Glaser R, Malarkey WB et al. Inflammation and reactivation of latent herpesviruses in older adults. Brain Behav Immun. 2012;26(5):739-746.

Nandakumar S, Woolard SN, Yuan D et al. Natural killer cells as novel helpers in anti-herpes simplex virus immune response. J Virol. 2008;82(21):10820-10831.

Ralainirina N, Poli A, Michel T. Control of NK cell functions by CD4+CD25+ regulatory T cells. J Leukoc Biol. 2007;81(1):144-153.

Roizman B, Knipe DM, Whitley R. Herpes Simplex Viruses. In book: Fields Virology, 5th ed. by D. Knipe, P. Howley. Philadelphia: Lippincott, Williams and Wilkins; 2007. 2502-2601.