• V. I. Tkachenko Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine,
  • L. O. Beresovska Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine,



vitamin D, 25(OH)D, cholecalciferol, 25-hydroxyvitamin D, glucose level, type 2 diabetes mellitus, carbohydrate metabolism


Background. Type 2 diabetes mellitus is a global public health problem. It is associated with serious complications, consequences and increased mortality. Despite the fact that treatment for diabetes and its complications has improved for the past few decades, the growing incidence of diabetes emphasizes the need for innovative approaches for the prevention and treatment of the disease. One of the uncertain directions is the estimation of role of vitamin D in the development and progression of type 2 diabetes. The purpose was to analyse the effect of vitamin D on the incidence and progression of type 2 diabetes by systematic analysis of literature. Materials and methods. Systematic analysis of data in the Pubmed, Medline and EMBASE databases for 2005-2019 for keywords related to vitamin D and diabetes mellitus. Results. The 22 studies from found 121 scientific papers were selected for analysis. All studies evaluated the effect of vitamin D on the incidence of type 2 diabetes. 10 studies have shown that intake of vitamin D in dosage > 500 IU per day reduces the risk of type 2 diabetes compared to vitamin D intake at low doses <200 IU per day. Several studies indicate that individuals with high vitamin D level in serum (> 25 ng / ml) had a lower risk of developing type 2 diabetes (95% confidence interval of 24.57%) compared with people with low vitamin D level (<14 ng / ml). The remaining 7 studies did not receive a significant relationship between the level of vitamin D or its use and the development of type 2 diabetes. Another 5 studies indicated the effect of vitamin D on the progression of diabetes and the development of complications such as diabetic polyneuropathy, diabetic retinopathy, and diabetic nephropathy. Conclusions. The evidence on the effect of vitamin D levels on the incidence and progression of type 2 diabetes is controversial, but most studies indicate an inverse relationship. This topic remains insufficiently studied and requires further observations. Based on the obtained data, examination of the level of vitamin D in serum and its intake in prophylactic doses can reduce the incidence of type 2 diabetes and its complications and improve treatment and preventive measures.


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