The role of polymorphism of genes of the I and II phase of xenobiotics biotransformation in the development of recurrent and chronic bronchitis in adolescent-smokers
DOI:
https://doi.org/10.26641/2307-0404.2017.2.109834Keywords:
recurrent and chronic bronchitis, adolescent-smokers, gene CYP1A1, gene GSTP1Abstract
The purpose of research – to study the role of allelic polymorphism of genes of the I and II phases of xenobiotics biotransformation in the development of reccurent and chronic diseases of the respiratory system in adolescent-smokers. There was carried out molecular-genetic study of the polymorphic locus Т3801С of gene CYP1A1 and polymorphic locus A313G of gene GSTP1 in adolescent-smokers with recurrent and chronic bronchitis. It is established that TТ genotype of the polymorphic locus Т3801С of gene CYP1A is a marker of resistance to the development of this pathology in adolescent-smokers. The presence of CC genotype of the polymorphic locus Т3801С of gene CYP1A1 and GG genotype of polymorphic locus of A313G GSTP1 gene may be considered as a possible risk factor for the development of chronic inflammatory process in bronchopulmonary system. Thus, the introduction of molecular-genetic methods of research opens up new possibilities in diagnosis of recurrent and chronic diseases of the respiratory system. Based on the analysis of genetic factors in children and adolescents, it will be possible to predict the risk of COPD developing in the future;this will allow doctors to carry out the necessary preventive activities among risk groups.
References
Gorovenko NG, Podolskaya SV, Chernjuk NV. [Determination of molecular-genetic markers of hereditary susceptibility to chronic obstructive pulmonary disease]. Ukrainian Pulmonology Journal. 2009;4:13-16. Ukrainian.
Dolinchuk LV, Basanets AV, Andrushchenko TA. [Genetic aspects of chronic obstructive pulmonary disease development]. Ukraїns'kii zhurnal z problem meditsini pratsі. 2013;1(34):44-56. Ukrainian.
Korytina GF, Ianbaeva DG, Victorova TV. [The role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and chronic respiratory tract diseases]. Molecular Biology. 2003;37(5):784-792. Russian.
Nevzorova VA, Vakhrusheva SE, Tilik TV, Isaeva MP. [Polymorphism of GSTP1 and EPHX1 genes in smokers and patients with chronic obstructive pulmonary disease stages I and II]. Pulmonology. 2013;1:32–37. Russian.
Morozova ОI,MorozovaNV, Ostrovskaja OV, Kozlov VК. [Application of molecular-genetic method of diagnostics in bronchopulmonary diseases in children]. Dal'nevostochnii meditsinskii zhurnal. 2010;2:48-51. Russian.
Rebrova OY. Statistical analysis of medical data. The use of the software package STATISTICA. 4th ed.Moscow: Media Sphere; 2002. Russian.
Chuchalin AG, Sacharova GM, Novikov KU. A practical guide to the treatment of tobacco dependence. 2001;1-14. Russian.
Yang L, Li X, Tong X, Fan H. Association between glutathione S-transferase P1 Ile (105) Val gene polymorphism and chronic obstructive pulmonary disease: A meta-analysis based on seventeen case-control studies.MetaGene. 2015;6:59-64. doi: http://dx.doi.org/10.1016/j.mgene.2015.08.007.
Bentley AR, Emrani P, Cassano PA. Genetic variation and gene expression in antioxidant related enzymes and risk of COPD: a systematic review. Thorax. 2008; 63 (11):956-961. doi: 10.1136/thx.2007.086199.
Berndt A,LemeAS, Shapiro SD. Emerging genetics of COPD. EMBO Molecular Medicine. 2012; 4:1144-1155. doi: 10.1002/emmm.201100627.
Vibhutia A, Arifa E, Mishraa A et al. CYP1A1, CYP1A2 and CYBA gene polymorphisms associated with oxidative stress in COPD. Clinica Chimica Acta. 2010;411:474-480. doi: 10.1016/j.cca.2009.12.018.
Fischer BM, Voynow JA, Ghio AJ. COPD: balancing oxidants and antioxidants. International Journal of COPD. 2015;10:261-276. doi: 10.2147/COPD.S42414.
Egan KM, Cai Q, Shu XO, et al. Genetic polymorphisms in GSTMl, GSTPl, and GSTTl and the risk for breast cancer: results from the Shanghai Breast Cancer Study and meta-analysis. Cancer. Epidemiol. Biomarkers. prev. 2004;13(2):197-204. doi: 10.1158/1055-9965.EPI-03-0294.
Imboden M, Downs SH, Senn O, et al. Glutathione S-transferase genotypes modify lung functiondecline in the general population: SAPALDIA cohort study. Respiratory Research. 2007;8(2):1-17. doi: 10.1186/1465-9921-8-2.
Cho MH, McDonald ML, Zhou X, et al. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. The Lancet Respiratory Medicine. 2014;2(3):214–225. doi: http://dx.doi.org/10.1016/S2213-2600(14)70002-5.
Wang C-D,NanC, Huang L, et al. Impact of CYP1A1 Polymorphisms on Susceptibility to Chronic Obstructive Pulmonary Disease: A Meta-Analysis. Biomed Res. Int. 2015;1–9. doi: 10.1155/2015/942958.
Foreman MG, DeMeo DL, Hersh СР, et al. Polymorphic variation in surfactant protein В is associated with COPD exacerbations. European Respiratory Journal. 2008; 32 (4): 938-944. doi: 10.1183/09031936.00040208.
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