Immunological features of parvovirus infection in different pregnancy periods.

Authors

  • N. P. Bondarenko
  • W. P. Lakatoch
  • P. W. Lakatoch

DOI:

https://doi.org/10.26641/2307-0404.2018.1(part1).127185

Keywords:

pregnancy, parvovirus infection, indicators of systemic immunity, cytokine profile of blood serum

Abstract

Parvovirus infection in pregnant women caused the development of immuno­patho­logical reactions.129 infected pregnant women and 16 women with physiological pregnancy in the 1st, 2nd and 3rd trimesters were examined. The functional state of neutrophils (Nph) and monocytes (Mc) of peripheral blood was investigated, parameters of cellular and humoral immunity and cytokine profile of serum of pregnant women were studied. In infected pregnant women in different periods of gestation as compared with pregnant women of control groups there were observed 1) an increase of index of phagocytosis Nph and Mc against the background of reducе of their absorption capacity and increasing NBT-activity with a decrease of reserve capacities of phagocytes; 2) an activation of the cellular immunity with an increase of helper mechanisms of the immune response; 3) a reliable increase of IgM level in serum in different periods of pregnancy; 4) a reliable increase of the content of IFN-γ, FNP-α, IL-2, IL-8 inserum against the background of a slight decrease in the level of anti-inflammatory IL-10. The largest deviations from the control indicators were recorded in the 1st trimester of pregnancy.

Author Biographies

N. P. Bondarenko

National Medical University named A.A. Bogomolets
Department of obstetrics and gynecology N 1
Predslavinskaya str., 9, Kyiv, 03150, Ukraine

W. P. Lakatoch

National Medical University named A.A. Bogomolets
Department of obstetrics and gynecology N 1
Predslavinskaya str., 9, Kyiv, 03150, Ukraine

P. W. Lakatoch

Kyiv Perinatal Center
Predslavinskaya str., 9, Kyiv, 03150, Ukraine

References

VankoLV, Safonova VT, Matveeva NK. [Oxida­tive stress in the genesis of obstetric complications]. Moskva, HEOTAR-Media. 2010;260. Russian.

Lavrentyeva IS, Аntipova АJ. [Parvovirus B19: Characteristics of the pathogen, distribution and diagnosis of the infection caused by it]. Infektsiya i immunitet. 2013;3(4):311-22. Russian.

Rebrova OJ. [Statistical analysis of medical data: application of the STATISTICA software package]. Moskva, Media Sfera. 2010;312. Russian.

Suchich T, Vanko LV. [Immune mechanisms in the physiology and pathology of pregnancy]. Immuno­logy. 2005;9(2):103-8. Russian.

Chaitov RM, Pinihin BV, Jarilin AA. [Guide to Clinical Immunology]. Diagnosis of diseases of the im­mune system: a guide for doctors. Moskva, HEOTAR-Media 2009;352. Russian.

Francesca G Bonvicini Gloria Bua, Giorgio Gal­linella. Parvovirus B19 infection in pregnancy – awareness and opportunities. Current Opinion in Viro­logy, 2017;27:8-14.

Joan Crane MD William Mundle MD, Isabelle Boucoiran MD. ParvovirusB19 InfectioninPregnancy. Jornal of Obstetrics and GynaecologyCanada, 2014;1107-16.

Cristiane Fernandes Ribeiro Vania, Gloria Silami Lopes, Patricia Brasil. Dengue infection in pregnancy and its impact on the placenta. International Journal of In­fectious Diseases, 2017;55:109-12.

Chau A, Markley JC, Juang J, et al. Cytocines in the perinatal period- Part I. International Journal of Obs­tetric Anesthesia. 2016;26:39-47.

Lamont RF, Sobel JD, Vaisbuch E, et al. Parvo­virus B19 infection in human pregnancy. BJOG: an Inte­r­national Journal of Obstetrics and Gynecology, 2011;118(2):175-86.

Melissa A Landek-Salgado, Noel R. Rose Pla­centa suppresses experimental autoimmune hypophysitis through soluble TNF receptor. Journal of Autoimmunity, 2012;38(2-3):J88-J96.

Mancini G, Carbonara AO, Heremans JF. Im­mu­nochemical quantitation of antigens by single radial im­munodiffusion.J. Immunochemistry, 1965;2(3):235-54.

Marlee Elston, Johann Urschitz. Transposase-me­diated gene modulation in the placenta. J. Placenta, 2017;59(1):32-36.

Peltier MR, Faux DS, Hamblin SD. Cytokine pro­duc­tion by peripheral blood mononuclear cells of women with a history of preterm birth. J. Reprod. Immunol, 2010;84(1):111-6.

Downloads

How to Cite

1.
Bondarenko NP, Lakatoch WP, Lakatoch PW. Immunological features of parvovirus infection in different pregnancy periods. Med. perspekt. [Internet]. 2018Apr.24 [cited 2024Apr.20];23(1(part1):9-14. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/127185

Issue

Vol. 23 No. 1(part1) (2018)

Section

CLINICAL MEDICINE

License

Copyright (c) 2018 Medicni perspektivi

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.

Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.