Experience in managing patients with Churg-Strauss syndrome.

A. A. Khanyukov, Т. V. Lakiza, Т. А. Simonova, L. S. Pryazhnikova, V. Yu. Poleshko, N. A. Romuz


Our goal was to analyze the possibilities of impro­ving the diagnostics of CSS and to improve the effectiveness of treatment according to the existing literature and our own experience of long-term care for patients with eosinophilic granulomatosis with polyangiitis or Churg-Strauss syndrome (CSS). The medical histories of three female patients aged 26 to 46-years and a 20-year-old male patient were considered. The duration of the disease before the established diagnosis was 5-17 years. Anamnesis and medical documents analysis showed a typical CSS debut in the form of allergic rhinitis, nasal polyps, which were recurrent after polypectomy, and respiratory disorders, which were regarded as bronchitis or bronchial asthma – corresponding to the first phase, also called the prodromal or allergic stage of CSS. The prodromal period lasts up to 10 years or more and is characterized by various allergic manifestations, more often –  pollinosis or bronchial asthma, that is difficult to control. But CSS can be suspected because of low effectiveness of the therapy with inhaled steroids, lack of effect of antibiotics and eosinophilia more than 10% that occurs periodically. Even in the third stage of CSS in systemic manifestations of vasculitis and severe secondary lesions of organs and tissues with functional impairment, constant intake of maintenance doses of corticosteroids and cytostatics allows to achieve stabilization of the process in patients with CSS.


Churg-Strauss syndrome; diagnosis; treatment


Beketova TV, Volkov MYu. [International re­commendations for the diagnosis and treatment of eosi­nophilic granulomatosis with polyangiitis]. Nauchno-prakticheskaya revmatologiya. 2016;54(2):129-37. Russian.

Kovalenko VM,SHubaNM. [Nomenclature, clas­sification, diagnostic criteria and treatment program for rheumatic diseases]. 2004;156. Ukrainian.

Kovalenko VM, SHuba NM, Gayko GV, Korzh MO, et al. [Nomenclature, classification, diagnostic cri­teria and treatment program for rheumatic diseases]. 2008;214. Ukrainian.

Knyaz’kova II. [The Churg-Strauss syndrome]. Klіnіch. іmunologіya. Alergologіya. Іnfektologіya. 2013;9/10:14-20. Ukrainian.

Lischuk-Yakimovich XO. ]Differential diagnosis of clinical course of bronchial asthma and Churg-Strauss syndrome on the background of eosinophilia]. Dosâg­nennâ bìologìï ta medicini. 2013;2:64-67. Ukrainian.

Moiseyev SV, Semenkova EN, Novikov PI. [The current nomenclature of systemic vasculitis - the re­commendations of the international consensus conference (Chapel Hill, 2012)]. Klinicheskaya nefrologiya. 2012;l(2):41-46. Russian.

CHop’yak VV, Lіshchuk-Yakimovich KO, Puka­lyak RM. [Immunologicalrisksofthe Churg-Strauss syn­drome in patients with bronchial asthma with eosi­nophilia]. Ukraïns′kij medičnij časopis. 2011;6:124-7. Ukrainian.

Churg J, Strauss L. Allergic granulomatosis, al­lergic angiitis, and periarteritisnodosa. Am J Pathol. 1951;27:277-94.

Masi AT, Hunder GG, Lie JT, et al. TheAme­ricanCollegeof Rheumatology 1990 criteria for the clas­sification of Churg-Strauss syndrome (allergic granu­lomatosis and angiitis). Arthritis Rheumatology. 1990;33:1094-100.

Watts RA, Scott DG. Epidemiology of vasculitis. In: L. Bridges, G. Ball (eds.) Vasculitis. 2nd ed. Oxford University Press, Oxford. 2008;2.

GOST Style Citations

  1. Бекетова Т. В. Международные рекомендации по диагностике и лечению эозинофильного грануле­матоза с полиангиитом / Т.В. Бекетова, М.Ю. Волков // Науч.-практ. ревматология. – 2016. – Т. 54, № 2. – С. 129-137.
  2. Коваленко В.М. Номенклатура, класифікація, критерії діагностики та програми лікування ревмат­ичних хвороб / В.М. Коваленко, Н.М. Шуба. – Київ, 2004. – 156 с.
  3. Коваленко В.М. Номенклатура, класифікація, критерії діагностики та програми лікування ревма­тич­них хвороб / В.М. Коваленко, Н.М. Шуба, Г.В. Гай­ко. – Київ, 2008. – 214 с.
  4. Князькова И.И. Синдром Чарджа-Стросс / И.И. Князькова // Клініч. імунологія. Алергологія. Ін­фектологія. – 2013. – № 9/10. – С. 14-20.
  5. Ліщук-Якимович Х.О. Диференційна діагнос­тика клінічного перебігу бронхіальної астми та син­дрому Чарджа-Стросса на фоні еозинофілії / Х.О. Лі­щук-Якимович // Досягнення біології та медицини. – 2013. – № 2. – С. 64-67.
  6. Моисеев С.В. Актуальная номенклатура сис­темных васкулитов – рекомендации международной консенсусной конференции (Чапел-Хилл, 2012) / С.В. Моисеев, Е.Н. Семенкова, П. И. Новиков // Кли­нич. нефрология. – 2012. – № 2. – С. 41-46.
  7. Чоп’як В.В. Імунологічні ризики розвитку синдрому Черджа-Строссу хворих н бронхіальну аст­му з еозинофілією / В.В. Чоп’як, Х.О. Ліщук-Якимо­вич, Р.М. Пукаляк // Укр. мед. часопис. – 2011 – № 6. – С. 124-127.
  8. Churg J. Allergic granulomatosis, allergic angiitis and periarteritisnodosa / J. Churg, L. Strauss // Am. J. Pathol. – 1951. – Vol. 27. – P. 277–301.
  9. The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (al­lergic granulomatosis and angiitis) / A.T. Masi, G.G. Hun­der, J. T. Lie [et al.] // Arthritis Rheum. – 1990. – Vol. 33, N 8. – P. 1094-1100.
  10.  Watts R.A. Epidemiology of vasculitis / R.A. Watts, D.G. Scott // Vasculitis / ed. L. Bridges, G. Ball – 2nd ed. – Oxford: Oxford University Press, 2008. – P. 21. 


This work is licensed under a Creative Commons Attribution 4.0 International License