Analysis of the level of expression of pancytokeratins in epithelial and granulocellular tumors of the ovaries.

Authors

  • O. A. Savchenko
  • I. S. Shponka

DOI:

https://doi.org/10.26641/2307-0404.2018.2.133693

Keywords:

epithelial ovarian tumors, granulo-cellular tumors, immunohistochemistry

Abstract

Differential diagnosis of ovarian neoplasms is carried out among groups of epithelial and granulocellular tumors and remains an actual problem of oncogynecology. In general, epithelial tumors  occur (up to 60%), but granulocellular cell tumors account for up to 5% of all ovarian neoplasia. Materials and methods. A retrospective study of 43 observations of ovarian tumor lesions over the period of January-December 2017 was conducted in the work. The aim of the study was to analyze the complex of morphological and immunohistochemical characteristics of Cytokeratin, Pan AE1 / AE3 - negative phenotypes and Cytokeratin, Pan AE1 / AE3 - positive phenotypes of ovarian neoplasia to improve diagnostic algorithms. Results. The phenotype of epithelial ovarian tumors in 100% of observations corresponds to pancytokeratin Cytokeratin, Pan AE1 / AE3 "+", in its turn the phenotype of granulocellular tumors basically responded to expression of the Cytokeratin marker, Pan AE1 / AE3 "-" in 62.5%; and the variant in the part of the cells "+" / "-" Cytokeratin, Pan AE1 / AE3 was found in 37.5% of granulocellular tumors, regardless of their malignant potential. Thus, granulocellular tumors have variable expression of the Cytokeratin marker, Pan AE1 / AE3 and require the inclusion of other diagnostic IGH markers in the primary panel.

Author Biographies

O. A. Savchenko

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of Pathological Anatomy and Forensic Medicine
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

I. S. Shponka

SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»
Department of Pathological Anatomy and Forensic Medicine
V. Vernadsky str., 9, Dnipro, 49044, Ukraine

References

Pozharsky KM, Raskin GA, Vinokurov VL, Yur­kova LE, Mukhina MS. [Immunohistochemical features of cells of serous ovarian adenocarcinoma, determining the clinical course of the disease and the survival of pa­tients]. Arkhiv patologii. 2015;1:38-40. Russian.

Sachiko Kitamura, Kaoru Abiko, Noriomi Matsu­mura. Adult granulosa cell tumors of the ovary: a retro­spective study of 30 cases with respect to the expression of steroid synthesis enzymes. Journal of Gynecologic Oncology. 2017;28(4):31-39.

Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;4:646-74.

Fletcher CDM. author. Diagnostic histopatology of tumors. PA: Elsevier. 2013;1:658-88.

Kurman RJ. Blaustein`s pathology of the female genital tract. Springer. 2001;791-904.

Mills SE, Carter D, Greenson JK. Diagnostic surgical pathology. Wolters Kluwer. 2010;2:2278-308.

Morikazu Miyamoto, Masashi Takano, Tadashi Aoyama. Seromucinous component in endometrioid endo­metrial carcinoma as a histological predictor of prognosis. Journal of Gynecologic Oncology. 2018;29(2):20-27.

Jiaheng Li, Riqiang Bao, Shiwei Peng The mo­lecular mechanism of ovarian granulosa cell tumors. Journal of Ovarian Research. 2018;11:13-20.

Tummala M, et al. Recurrent ovarian can­cer. Clini­cal Advances in Hematology and Oncology. 2005;3:723-36.

Kurman RJ, Carcangiu ML, Herrington CS, Young RH. WHO Classification of tumors of female repro­ductive organs. Revised 4th ed. Lyon, IARC. 2014;307.

How to Cite

1.
Savchenko OA, Shponka IS. Analysis of the level of expression of pancytokeratins in epithelial and granulocellular tumors of the ovaries. Med. perspekt. [Internet]. 2018Jun.25 [cited 2024Mar.29];23(2):21-5. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/133693

Issue

Section

THEORETICAL MEDICINE