DOI: https://doi.org/10.26641/2307-0404.2018.3(part1).142352

Changes in parameters of function of external respiration in patients with end stage of chronic kidney disease who are on substitution therapy.

O. V. Kuryata, O. O. Shtepa, O. V. Halushchak

Abstract


The aim of our study was to evaluate the changes in the parameters of function of external respiration in patients with end-stage of chronic kidney disease after kidney transplantation in connection with chronic kidney disease under conditions of replacement therapy and compare with the results in patients after kidney transplantation. The first group included 40 patients with end-stage of chronic kidney disease under conditions of replacement dialysis therapy. The second group included 19 patients after kidney transplantation. A significant difference (p˂0,05) was found in patients of the first and second groups between the indicators of the FVC (90 [75-110]% и 98 [91-108]%), FEV1 (79 [71-93]% и 96 [84-104]%), PEF (61 [40-87]% и 82 [64-94]%), MEF 25-75 (52,5 [39-71]% и 80 [66-112]%). The indices of both groups were significantly lower relative to the comparison group: FVC (107,5 [105,5-124]%), FEV1 (100,5 [96-105,5]%), PEF (99,5 [95-102,5]%), MEF 25-75 (98,5 [97,5-101,5]%). In both groups, a statistically significant negative correlation was found between the indicators of the VCmax, FEV1, PEF, MEF 25-75 (R = -0,46, p <0,005; R = -0,43, p<0.05; R = -0,73, p <0,05; R = -0,41, p <0,05). Moderate decrease in the parameters of VCmax, FEV1, PEF, MEF 25-75  in patients with end-stage of chronic kidney disease requires monitoring of FVC with spirometry, especially in conditions of hemodialysis.


Keywords


function of external respiration; end-stage of chronic kidney disease; kidney transplantation

References


Kuryata OV, Shtepa OO, Halushchak OV. [Func­tion of external respiration in patients after kidney transplantation under conditions of immunosuppressive therapy]. Mediсni perspectivi. 2018;23(1 part 1):95-101. Ukrainian.

Pertseva TO, Kіreєva TV, Shtepa OO. [The influence of comorbid pathology on expressiveness of inflammantory process in patients with lower respiratory tract infections]. Zaporozhye medical journal. 2015;4(91):21-25. Ukrainian.

Pertseva TA, Konopkina LI. [Fundamentals of the study of the ventilation function of the lungs: clinical and diagnostic value. Methodical manual for doctors and students of medical schools]. Dnepropetrovsk, «Art-Press». 2008;66. Russian.

Canet E, Osman D, Lambert V et al. Acute res­piratory failure in kidney ransplant recipients: a multi­center study. Critical Care. 2011;15(91):2-10.

Thompson S, James M, Wiebe N et al. Cause of death in patients with reduced kidney function. J Am Soc Nephrol. 2015;10:2504-11.

Тurin TC, Tonelli M, Manns BJ, Ravani P et al. Chronic kidney disease and life expectancy. Nephrol Dial Transplant. 2012;27:3182-6.

Cury JL, Brunetto AF, Aydon RD. Negative effects of chronic kidney failure on lung function and functional capacity. Rev Bras Fisioter. 2010;14(2):91-98.

Ivanov DD, Kuryata OV, Garmysh IP. Renin an­giotensin-aldosterone system blokers: chronic kidney di­sease and cardiovascular risk. Kidneys. 2018;2(7):13-23.

Kovacević P, Stanetic M, Rajkovaca Z et al. Changes in spirometry over time in uremic patients receiving long-term hemodialysis therapy. Pneumologia. 2011;60(1):36-39.

Kupeli E, Ulubay G, Colak T, et al. Pulmonary Complications in Renal Recipients after Transplantation. Transplantation Proceedings. 2011;43:551-3.

Rezaeetalab F, Zeraati A, Fadaeian AH et al. Spirometric parameters: Hemodialysis compared to peritoneal dialysis. J Cardiothorac Med. 2015;3(2):293-96.

Senatore M, Buemi M, Di Somma A et al. Res­piratory function abnormalities in uremic patients. G Ital Nefrol. 2004;21(1):29-33.

United States Renal Data System Morta­lity. In: USRDS annual data report: epidemiology of kidney disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. Bethesda. 2015;6(2). Available from: www.usrds.org/2015/download/vol2_06_Mortality_15.pdf

Yilmaz S et al. Pulmonary function in patients with end-stage renal disease. Med Sci Monit. 2016;22:2779-84.


GOST Style Citations


  1. Курята О.В. Функція зовнішнього дихання у хворих після трансплантації нирки в умовах імуно­супресивної терапії / О. В. Курята, О. О. Штепа, О.В. Галущак // Медичні перспективи. – 2018. – Т. XXIII, № 1, ч. 1. – С. 95–101.
  2. Перцева Т. О. Вплив коморбідної патології на виразність запального процесу у хворих на інфекції нижніх дихальних шляхів / Т.О. Перцева, Т.В. Кі­реєва, О.О. Штепа // Запорож. мед. журнал. – 2015. – № 4 (91). – С. 21–25.
  3. Перцева Т. А. Основы изучения вентиляцион­ной функции легких: клинико-диагностическое зна­чение: метод. пособие для врачей и студентов мед. вузов / Т. А. Перцева, Л. И. Конопкина // Днепропет­ровск: Арт-Пресс, 2008. – 66 с.
  4. Acute respiratory failure in kidney ransplant recipients: a multicenter study / E. Canet, D. Osman, V. Lambert [et al.] / Critical Care. – 2011. – Vol. 15, N 91. – P. 2-10.
  5. Cause of death in patients with reduced kidney function / Thompson S, James M, Wiebe N [et al.] // J. Am. Soc. Nephrol. – 2015. – N 10. – P. 2504-2511. 
  6. Chronic kidney disease and life expectancy / T.C. Тurin, M. Tonelli, B.J. Manns, P. Ravani [et al.] // Nephrol Dial Transplant. – 2012. – Vol. 27. – P.3182–3186.
  7. Cury J.L. Negative effects of chronic kidney fai­lure on lung function and functional capacity / J.L. Cury, A.F. Brunetto, R.D. Aydon / Rev. Bras. Fisioter. – 2010. – Vol. 14, N 2. – P. 91-98.
  8. Ivanov D.D. Renin angiotensin-aldosterone sys­tem blokers: chronic kidney disease and cardiovascular risk / D.D. Ivanov, O.V. Kuryata, I.P. Garmysh // Kidneys – 2018. – Vol. 2, N 7. – P. 13-23.
  9. Kovacević P. Changes in spirometry over time in uremic patients receiving long-term hemodialysis therapy / P. Kovacević, M. Stanetic, Z. Rajkovaca [et al.] // Pneumologia. – 2011. – Vol. 60, N 1. – P. 36-39.
  10. Pulmonary Complications in Renal Recipients after Transplantation / E. Kupeli, G. Ulubay, T. Colak [et al.] // Transplantation Proceedings. – 2011. – Vol. 43. – P. 551-553.
  11. Rezaeetalab F. Spirometric parameters: Hemodia­lysis compared to peritoneal dialysis / F. Rezaeetalab, A. Zeraati, A.H. Fadaeian [et al.] // J Cardiothorac Med. – 2015. – Vol. 3, N 2. – P. 293-296.
  12. Senatore M. Respiratory function abnormalities in uremic patients / M. Senatore, M. Buemi, A. Di Somma [et al.] // G. Ital. Nefrol. – 2004. – Vol. 21, N 1. – P. 29-33.
  13. United States Renal Data System (2015) Mor­tality. In: USRDS annual data report: epidemiology of kidney disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases / Bethesda. – chapter 6, vol 2. Available: http://www.usrds.org/2015/download/vol2_06_Mortality_15.pdf
  14. Yilmaz S. Pulmonary function in patients with end-stage renal disease / S. Yilmaz // Med. Sci. Monit. – 2016. – Vol. 22. – P. 2779-2784.