Clinical and epidemiological features of chronic pancreatitis course associated with atherosclerosis.

Authors

  • E. S. Sirchak
  • S. M. Opalenyk

DOI:

https://doi.org/10.26641/2307-0404.2018.3(part1).142373

Keywords:

chronic pancreatitis, epidemiology, 13C-mixed triglyceride respiratory test, 13C-amylase respiratory test, dyslipidemia

Abstract

The article describes and analyzes dyslipidemic disorders, the degree of pancreatic external secretion insufficiency in patients with chronic pancreatitis. The purpose of our study is to study the changes in the blood lipid profile in patients with chronic pancreatitis depending on the degree of pancreatic external secretion insufficiency in residents of the city and villages. We carried out the 13C-mixed triglyceride respiratory test (13C-MTRT) and the 13C-amylase respiratory test (13C-ART) to detect the pancreatic external secretion insufficiency (PESI). Changes in the blood lipid profile were based on the violations in the lipidogram (determination of total blood cholesterol level (TC), triglycerides (TG), high density lipoproteins (HDL), and low density lipoproteins (LDL), atherogenicity coefficient (CA)). All examined patients with combination of chronic pancreatitis (CP) and athe­rosclerosis have lipid metabolism disorders, but the changes in the city residents are more significant as compared with the rural population. It was also found that the most pronounced violation of the PESI was observed in patients with CP and lipid metabolism disorders, who were residents of the city. In these patients, during the 13C- MTRT, the maximum concentration of 13СО2 between 150 and 210 minutes were at the level of 4.9±0.7%; total concentration of 13СО2 at the end of the study (360 min.) – 17,1±0,3% and were statistically significant in comparison with the control group.

Author Biographies

E. S. Sirchak

SHEE «Uzhgorod National University»
Faculty of Medicine, Department of propaedeutics of internal diseases
Narodna sq., 1, Uzhgorod, 88000, Ukraine

S. M. Opalenyk

SHEE «Uzhgorod National University»
Faculty of Medicine, Department of propaedeutics of internal diseases
Narodna sq., 1, Uzhgorod, 88000, Ukraine

References

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How to Cite

1.
Sirchak ES, Opalenyk SM. Clinical and epidemiological features of chronic pancreatitis course associated with atherosclerosis. Med. perspekt. [Internet]. 2018Oct.26 [cited 2024Mar.28];23(3(part1):188-92. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/142373

Issue

Section

THEORETICAL MEDICINE