Genotype of cytochrome-450 2C9 in patients with tuberculosis

Authors

  • V. V. Filyuk Odesa regional antituberculous dispensary, Ukraine
  • V. I. Kresyun Odesa national medical university, Ukraine
  • P. B. Antonenko Odesa national medical university, Ukraine
  • K. K. Rogach Odesa regional antituberculous dispensary, Ukraine
  • Yu. M. Danylenko Odesa regional antituberculous dispensary, Ukraine
  • G. V. Mozolevych Odesa regional antituberculous dispensary, Ukraine

DOI:

https://doi.org/10.26641/2307-0404.2013.2.15949

Keywords:

CYP2C9 gene, polymorphism, genotype, tubercuosis

Abstract

The aim of present work was to investigate CYP2С9 polymorphism in the south of Ukraine in TB-patients and comparing with the same data of control group by the example of Odessa region. Gene CYP2С9 polymorphism was studied with the help of PCR (polymerase chain reaction) and endonuclease analysis. The blood samples were obtained from patients with new cases of pulmonary TB from Odessa regional antituberculous dispensary and healthy donors in Odessa district station of blood transfusion in the year 2010-12. According to genotype of CYP2C9 of 55 TB-patients, 67,3% persons were the carriers of  homozygote wild gene CYP2C9*1/*1, 21,8 and 3,6% - heterozygote genes CYP2C9*1/*2 and CYP2C9*1/*3. Only 7,2% individuals belonged to carriers of slow metabolizers genotype - CYP2C9*2/*2, *2/*3, *3/*3. In general, the mutated alleles CYP2C9*2 and CYP2C9*3 in TB-males were observed by 1,8 times more frequently than among healthy donors of the same gender. TB-patients older than 30 years more frequently had mutated allele CYP2C9*2, almost by 3 times than individuals from control group.

Author Biographies

V. I. Kresyun, Odesa national medical university

General and clinical pharmacology department

P. B. Antonenko, Odesa national medical university

General and clinical pharmacology department

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Published

2013-07-30

How to Cite

1.
Filyuk VV, Kresyun VI, Antonenko PB, Rogach KK, Danylenko YM, Mozolevych GV. Genotype of cytochrome-450 2C9 in patients with tuberculosis. Med. perspekt. [Internet]. 2013Jul.30 [cited 2024Apr.19];18(2):61-6. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/15949

Issue

Vol. 18 No. 2 (2013)

Section

CLINICAL MEDICINE

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