Behavioral disorders in rats with chronic myocardial dysfunction.
DOI:
https://doi.org/10.26641/2307-0404.2014.3.28506Keywords:
behavioral disorders, myocardial dysfunction, doxorubicin, emotion, anxietyAbstract
Observation of cardiologists and psychiatrists suggest that cardiovascular diseases and depression are the most common and frequent comorbid conditions. Therefore the aim of the study was to identify behavioral disorders in rats on the background of myocardial dysfunction in the experiment. Material of the research: 60 adult male rats of Wistar line, weighing 200-220 g, divided into 2 groups - control and experimental. Myocardial dysfunction was modeled by intraperitoneal injection of doxorubicin by 5 mg/kg of animal weight. To verify the model of myocardial dysfunction ECG and histological examination of the myocardium were performed. Evaluation of higher divisions of the CNS reactions was performed using the "open field" method by such indicators: vertical and horizontal motor activity (decreased by 71,4%), acts and defecation boluses (down by 85-88%), the number of burrows (decreased by 57-90%), grooming (decreased by 23%), all parameters were reliable (in p<0,05). There was a gradual decline of rats’ emotionality, CNS depression and increased anxiety. It was found that behavioral disorders in the experiment were typical for anxiety and depression states.References
Антомонов М. Ю. Математическая обработка и анализ медико-биологических данных / М.Ю. Анто¬монов. – К., 2006. – 558 с.
Буреш Я. Методики и основные эксперименты по изучению мозга и поведения / Я. Буреш, О. Бу¬ре¬шо¬ва, Д. П. Хьюстон — М.: Высш. шк., 1991. — 399 с.
Діагностика та лікування депресій у хворих на ішемічну хворобу серця, які перенесли стенування ко¬ронарних артерій / Л.М. Юр’єва, Л.І. Васильєва, О.Й. Мам¬чур [та ін.] – Дніпропетровськ: РВА «Дні¬про-VAL», 2009. — 87 с.
Калуев А.В. Изучение тревожности у живот¬ных – вчера, сегодня, завтра // Стресс и поведение: материалы 7-й междисциплинарной конф. по биоло¬гической психиатрии. – М., 2003. – С. 145-148.
Лабораторные животные. Разведение, содер¬жание, использование в эксперименте / И.П. Запад¬нюк, В.И. Западнюк, Е.А. Захария, Б.В. Западнюк. ― 8-е изд., перераб. и доп. ― К.: Вища школа, 1983. – 383 с.
Расстройства памяти в психоневрологической практике. Методическое пособие / А.Л. Дроздов, Л.А. Дзяк, А.Н. Кушнир, Н.Г. Вишневская. − Днепро¬петровск, 2005. ― 38 с.
Регионарные особенности развития и строения сердца в онтогенезе / Л.В. Абдул-Оглы, С.В. Козлов, В.В. Кошарный [и др.] ― Днепропетровск, 2014. ― 248 с.
Ромейс Б. Микроскопическая техника / Б. Ро¬мейс [пер. с нем.]. ― М.: Изд−во иностр. литературы, 1953. – 718 с.
LaManna J.C. Structural and functional adapta¬tion to hypoxia in the rat brain / J.C. LaManna, J.C. Chavez, P. Pichiulec // J. Experim. Biology. – 2007. – P. 3163-3169.
Relationship between left ventricular dysfunction and depression following myocardial infarction: data from the MIND–IT / J. P. Van Melle, P. de Jonge, J. Ormel [et al.] // Eur. Heart. J. – 2005. – Vol. 26. – P. 2650-2656.
Treatment of depression after coronary artery by¬pass surgery: a randomized controlled trial / K.E. Freed¬land, J.A. Skala, R.M. Carney [ et al.] // Arch. Gen. Psy¬chiatry. ― 2009. ― Vol. 66, N 4. ― P. 387-396.
Antomonov MYu. [Mathematical processing and analysis of biomedical data]. 2006;558. Ukrainian.
Buresh Ya. [Techniques and basic experiments to study the brain and behavior]. 1991;399. Russian.
Yur'eva LN, Vasil'eva LI, Mamchur OI. [Dia¬gnosis and treatment of depression in patients with coronary heart disease who underwent coronary artery stenuvannya]. 2009;87. Ukrainian.
Kaluev AV. [Study of anxiety in animals - yesterday, today and tomorrow]. Stress and Behavior: Proceedings of the 7th Interdisciplinary Conference of the biological psychiatry. 2003;145-8. Russian.
Zapadnyuk IP. [Laboratory animals. Breeding, maintenance, use in the experiment]. 1983;383. Uk¬rainian.
Drozdov AL. [Memory disorders in mental prac¬tice. Toolkit]. 2005;38. Ukrainian.
Abdul-Ogly LV, Kozlov SV, Kosharnyy VV. [Regional
features of the development and structure of the heart in the ontogeny]. 2014;248. Ukrainian.
Romeys B. [Microscopic technique]. 1953:718. Russian.
LaManna JC, Chavez JC, Pichiulec P. Structural and functional adaptation to hypoxia in the rat brain. J. of exper. Boil. 2007;3163–9.
Van Melle JP, Jonge de P, Ormel J. Relationship between left ventricular dysfunction and depression following myocardial infarction: data from the MIND. J. Eur Heart. 2005;26:2650–6.
Freedland KE. Treatment of depression after co¬ronary artery bypass surgery: a randomized controlled trial. Arch. Gen. Psychiatry. 2009;66:387–96.
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