L-lysine escinat, thiotriazolin, gordox and mydocalm influence on oxygen tension in the intestinal wall and acid-base balance and limited proteolysis in intestinal venous blood in terms of intraabdominal hypertension modeling.

Authors

  • V. I. Sapegin
  • I. D. Sapegin
  • F. N. Ilchenko

DOI:

https://doi.org/10.26641/2307-0404.2014.4.35587

Keywords:

Abdominal Compartment Syndrome, intestinal blood circulation, acid-base balance, limited proteolysis, thiotriazolin, L-lysine escinat, tolperison, aprotinin

Abstract

In acute experiments on rabbits there were studied changes in oxygen tension in the intestinal wall tissues, acid-base balance and limited proteolysis and its inhibitors in intestinal venous blood, protective action of L-lysine escinat (0,15 mg/kg / single dose), thiotriazolin (25 mg/kg / single dose), aprotinin (gordox) (10,000 units/kg / single dose) in sequential modeling of standard levels increasing of intra-abdominal hypertension (IAH) — 50, 100, 150, 200, 250, 300, 350 m H2O, and also of tolperison (mydocalm) (5 mg/kg / single dose) on modeling of stable 3-hour IAH 200 m H2O. The IAH modeling was performed by means of stand of our construction. Under the influence of IAH the compensated metabolic acidosis in intestinal venous blood with a compensative hyperpnoe develops, decline of oxygen tension in tissues and activating of a limited proteolysis as well as decline of its inhibitors activity in intestinal venous blood occur. By the degree of metabolic acidosis prevention investigational preparations were distributed as follows gordox > thiotriazolin = L-lysine escinat = mydocalm, and by prevention of decline of oxygen tension in tissues — thiotriazolin > L-lysine escinat > mydocalm > gordox, it is is connected with different rate of methabolic products excretion into the blood, due to the influence on blood circulation and transcapilary exchange. By the degree of prevention of proteolytic activity and inhibitory potential changes, investigational preparations were distributed as follows: gordox > mydocalm > thiotriazolin > L-lysine escinat, this is connected with inhibition of proteolysis in gordox, and in other ones – with reduction of ischemic damage of tissues. Owing to different mechanism of action thiotriazolin,  L-lysine escinat and mydocalm may be simultaneously recommended for a conservative treatment of patients with intraabdominal hypertension syndrome.

Author Biographies

V. I. Sapegin

Crimea State Medical University named after S.I. Georgievsky
Surgery departament N 2
Pharmacology departament
Lenin Boulvar, 5/7, Simferopol, 95006,Crimea

I. D. Sapegin

Crimea State Medical University named after S.I. Georgievsky
Surgery departament N 2
Pharmacology departament
Lenin Boulvar, 5/7, Simferopol, 95006,Crimea

F. N. Ilchenko

Crimea State Medical University named after S.I. Georgievsky
Surgery departament N 2
Pharmacology departament
Lenin Boulvar, 5/7, Simferopol, 95006,Crimea

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Kozek-Langenecker SA, Mohammad SF, Masaki T. The effects of aprotonin on platelets in vitro using whole blood flow cytometry. Anesth Analg 2000;90(1):12-16.

Avraamidou A, Marinis A, Asonitis S. The im¬pact of ischemic preconditioning on hemodynamic, biochemical and inflammatory alterations induced by intra-abdominal hypertension: an experimental study in a porcine model. Langenbecks Arch Surg. 2012;397(8):1333-41.

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Published

2014-11-24

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1.
Sapegin VI, Sapegin ID, Ilchenko FN. L-lysine escinat, thiotriazolin, gordox and mydocalm influence on oxygen tension in the intestinal wall and acid-base balance and limited proteolysis in intestinal venous blood in terms of intraabdominal hypertension modeling. Med. perspekt. [Internet]. 2014Nov.24 [cited 2024Mar.28];19(4):4-12. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/35587

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THEORETICAL MEDICINE