DOI: https://doi.org/10.26641/2307-0404.2014.4.35806

Cardiovascular risk factors in patients with rheumatoid arthritis in combination with hypertension depending on body weight.

O. Yu. Sіrenko

Abstract


The objective was to evaluate the frequency of cardiovascular risk factors and hypertension in patients with rheumatoid arthritis depending on body weight. The study involved 100 patients with rheumatoid arthritis and stably selected therapy for more than 6 months at the age from 45 to 65 years (mean age 53,19 ± 5,40 years). Traditional cardiovascular risk was assessed, taking into account risk factors by SCORE scale and amended for patients with RA. The levels of total cholesterol, triglycerides, C-reactive protein, serum creatinine, body mass index, body area index were determined. Arterial hypertension was diagnosed in 41 (41%) patients with rheuma­toid arthritis and was associated with traditional risk factors (age, obesity), rheumatoid factor, hyperuricemia and the duration of glucocorticoid therapy. Obesity and excess body mass occurred in the majority of patients with rheumatoid arthritis, herewith the highest level of inflammation indicators and risk of cardiovascular events was in overweight patients. Obesity was associated with duration of rheumatoid arthritis, the activity of the inflammatory process, the duration of glucocorticoids taking. It is found that the traditional SCORE scale does not fully reflect the risk of cardiovascular events in rheumatoid arthritis. Identification of hypertension and obesity increases the information content of the risk assessment of cardiovascular events in rheumatoid arthritis.

Keywords


cardiovascular risk factors; hypertension; rheumatoid arthritis; body mass index

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References


Коваленко В.М. Номенклатура, класифікація, критерії діагностики та програми лікування ревма¬тичних хвороб / В.М. Коваленко, Н.М. Шуба – К.: Кат¬ран груп, 2002. – 214 с.

Курята О.В. Фактори ризику та субклінічні проя¬ви атеросклерозу у хворих на системний черво¬ний вовчак / О.В. Курята, О.Ю. Нода, Т.К. Лисунець // Укр. ревматол. журнал. – 2011. – №3(45) – С. 82-87.

Попкова Т.В. Факторы риска кардиовас¬ку¬лярных заболеваний при ревматоидном артрите / Т.В. Попкова, Д.С. Новикова, В.В. Писарев // Науч.-практ. ревматология. – 2009. – № 3 – С. 4-11.

Про затвердження протоколів надання медич¬ної допомоги за спеціальністю «Ревматологія»: наказ МОЗ України № 676 від 12.10.2006 / Офіційний сайт МОЗ України. Режим доступу: (www.moz.gov.ua).

Про затвердження та впровадження медико-технологічних документів зі стандартизації медичної допомоги при артеріальній гіпертензії: наказ МОЗ України № 384 від 24.05.2012 р. / Офіційний сайт МОЗ України. Режим доступу: (www.moz.gov.ua).

Реброва О.Ю. Статистический анализ меди¬цинских данных. Применение пакета прикладных программ STATISTIKA / О.Ю. Реброва. – М.: Медиа Сфера, 2002. – 312 с.

Associations of obesity with modifiable risk factors for the development of cardiovascular disease in patients with rheumatoid arthritis / A. Stavropoulos-Kalinoglou, G.S. Metsios, V.F. Panoulas [et al.] // Ann. Rheumatic Diseases. – 2009. – N 68 – Р. 242-245.

Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and anky¬losing spondylitis / C. Han, D.W. Robinson, M.V. Hackett [et al.] // Rheumatology. – 2006. – N 33 – Р. 2167-72.

Cardiovascular disease in patients with rheuma¬toid arthritis: results from the QUEST-RA study / A. Naranjo, T. Sokka, M.A. Descalzo [et al.] //Arthritis Research & Therapy. – 2008 – Vol. 10, N. 2: R30.

Meune C. Trends in cardiovascular mortality in patients with rheumatoid arthritis over 50 years: a syste¬matic review and meta-analisis of cohort studies / C. Meune, E. Touze, L. Trinqurte // Rheumatology. – 2009. – Vol. 48, N 10. – Р. 1309-1313.

Peters M.J. EULAR evidence-based recommen¬dations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis / M.J. Peters, D.P. Symmons, D. McCarey // Ann. Rheumatic Diseases. – 2010. – Vol. 69 – Р. 325-331.

Prevalence and associations of hypertension and its control in patients with rheumatoid arthritis / V.F. Pa¬noulas, K.M. Douglas, H.J. Milionis, A. Stavropoulos-Ka¬linglou [et al.] // Rheumatology. – 2007. – Vol. 46, N 9 – P.1477-1482.

Prognostic importance of low body mass index in relation to cardiovascular mortality in rheumatoid arthritis / H.M. Kremers, P.J. Nicola, C.S. Crowson, K.V. Ballman [et al.] // Arthritis & Rheumatism. – 2004 – Vol. 50, N.11 – Р. 3450-3457.

The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardio¬vas¬cular Di¬sea¬se Prevention in Clinical Practice. Euro¬pean Guidelines on car¬diovascular disease prevention in clini¬cal practice: full text (update 2012) // Eur.Heart J.-2012.-Vol.33.-P.1635–1701.

Treatment to lipid targets in patients with inflam¬matory joint diseases in a preventive cardio-rheuma clinic / Silvia Rollefstad, Tore K Kvien, Ingar Holme, Anne S Eirheim [et al.] // Ann. Rheumatic Diseases. – 2013. – Vol. 12, N 72 – Р. 1968-1974.

REFERENCES

Kovalenko VM, Shuba NM. [Nomenclature, classification, diagnostic criteria and treatment programs of rheumatic diseases]. Kiev. «Katran grup»; 2002. Uk¬rainian.

Kuryata OV, Noda OYu, Lusunets TK. [Risk factors and subclinical manifestations of atherosclerosis in patients with systemic lupus erythematosus]. Ukraїns'kij revmatologіchnij zhurnal. 2011;3(45):82-87. Ukrainian.

Popkova TV, Novikova DS, Pisarev VV. [Risk fac¬tors of cardiovascular diseases in rheumatoid arthritis]. Nauchno-prakticheskaja revmatologija. 2009;3:4-11. Russian.

[On approval of the protocols of medical care in Rheumatology. Order of HM of Ukraine from 12.10.2006 N 676]. Available from: http://www.moz.gov.ua. Uk¬rainian.

[On approval and implementation of medical and technical documents on standardization of medical care in hypertension. Order of HM of Ukraine from 24.05.2012 N 384]. Available from: http://www.moz.gov.ua. Uk¬rainian.

Rebrova OYu. [Statistical analysis of medical data. The use of the application package STATISTICA]. Media Sfera; 2002. Russian.

Stavropoulos-Kalinoglou A, Metsios GS, Pa¬noulas VF et al. Associations of obesity with modifiable risk factors for the development of cardiovascular disease in patients with rheumatoid arthritis. J. Annals of the Rheumatic Diseases. 2009;68:242–45.

Han C, Robinson DW, Hackett MV. Cardio¬vascular disease and risk factors in patients with rheuma¬toid arthritis, psoriatic arthritis, and ankylosing spon¬dylitis. J. Rheumatology. 2006;33:2167-72.

Naranjo A, Sokka T, Descalzo MA et al. Cardio¬vascular disease in patients with rheumatoid arthritis: results from the QUEST-RA study. J Arthritis Research & Therapy. 2008;10(2):R30.

Meune C, Touze E, Trinqurte L. Trends in cardio¬vascular mortality in patients with rheumatoid arthritis over 50 years: a systematic review and meta-analisis of cohort studies. J. Rheumatology. 2009;48(10):1309-13.

Peters MJ, Symmons DP, McCarey D. EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis. J. Annals of the Rheumatic Diseases. 2010;69:325-31.

Panoulas VF, Douglas KM, Milionis HJ, Stav¬ropoulos-Kalinglou A, Nightingale P, Kita MD, Tselios AL, Metsios GS, Elisaf MS, Kitas GD. Prevalence and associations of hypertension and its control in patients with rheumatoid arthritis. J. Rheumatology. 2007;46(9):1477-82.

Kremers HM, Nicola PJ, Crowson CS, Ballman KV, Gabriel SE. Prognostic importance of low body mass index in relation to cardiovascular mortality in rheuma¬toid arthritis. J. Arthritis & Rheumatism. 2004;50(11):3450-57.

The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardio¬vascular Disease Prevention in Clinical Practice. Euro¬pean Guidelines on cardiovascular disease prevention in clinical practice: full text (update 2012). Eur.Heart J. 2012;33:1635–01.

Silvia Rollefstad, Tore K Kvien, Ingar Holme, Anne S Eirheim, Terje R Pedersen, Anne Grete P Semb. Treatment to lipid targets in patients with inflammatory joint diseases in a preventive cardio-rheuma clinic. J. Annals of the Rheumatic Diseases. 2013;12(72):1968-74.


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