2024-03-29T05:23:54Z
https://journals.uran.ua/index.php/2307-0404/oai
oai:ojs.journals.uran.ua:article/124952
2018-04-23T07:40:54Z
2307-0404:RA
driver
2786-4804
2307-0404
dc
Bone marrow fibrosis – the basis of mielofibrosis: pathogenesis, prognostication and antifibrogenic targeted strategies.
Timchenko, A. S.
Zalessky, V. N.
Bone marrow fibrosis is a key patological feature and major diagnostic criterion of mielofibrosis. Although bone marrow fibrosis is manifested in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the mielofibrosis of hematopoietic stem/progenitor cells, contributing to an impaired microenvironment toward malignant over normal hematopoiesis. The increased expression of proinflammatory cytokines, transforming growth factor-β, impaired megakaryocyte function and aberrant JAK-STAT signaling are the peculiarities of pathogenesis of bone marrow fibrosis. Hematopoietic stem cell transplantation remains the only therapeutic approach that reliably results in resolution of bone marrow fibrosis in patients with mielofibrosis. In the work we review the pathogenesis, biological consequences and prognostic results of impact of bone marrow fibrosis. We discuss the rationale of various anti-fibrogenic treatment strategies targeting at clonal hematopoietic stem/progenitor cells, aberrant signaling pathway, fibrogenic cytokines, and tumor microenvironment.
Dnipro State Medical University
2018-04-02 16:58:13
application/pdf
https://journals.uran.ua/index.php/2307-0404/article/view/124952
Medicni perspektivi; Vol. 23 No. 1 (2018)
eng
##submission.copyrightStatement##
oai:ojs.journals.uran.ua:article/124953
2018-04-23T07:40:54Z
2307-0404:RA
driver
2786-4804
2307-0404
dc
Breast cancer and body weight index: the role of L-carnitine in prediction of answer to treatment and outcome of tumor in patients with obesity (review of literature).
Hojouj, M.I.M.,
Bondarenko, I. N.
Zavizion, V. F.
Artemenko, M. V.
Hojouj, T. V.
Bondarenko, Yu. N.
Soloviova, N. E.
Shevchenko, Y. A.
Increasing the effectiveness of antitumor therapy in breast cancer patients who take L-carnitine during preoperative systemic antitumor therapy compared with patients receiving standard neoadjuvant systemic antitumor therapy served as a prerequisite for studying possible antitumor mechanisms of L-carnitine. The positive effect of L-carnitine is due to the transfer of palm-n-fatty acid through the inner membrane into the mitochondrial matrix, which contributes to the formation of a significant number of ATP molecules. It has also been shown that L-carnitine can have a double protective effect, enhancing the energy dynamics of the cell and inhibiting the hyperexcitability of the cell membrane, making it an ideal tool for the prevention and treatment of complications of antitumor therapy and concomitant metabolic disorders. This work summarizes the results of epidemiological and clinical studies on the use of L-carnitine in the treatment of breast cancer.
Dnipro State Medical University
2018-04-02 16:58:13
application/pdf
https://journals.uran.ua/index.php/2307-0404/article/view/124953
Medicni perspektivi; Vol. 23 No. 1 (2018)
eng
##submission.copyrightStatement##
oai:ojs.journals.uran.ua:article/254472
2022-04-05T11:37:47Z
2307-0404:RA
driver
"220330 2022 eng "
2786-4804
2307-0404
dc
Roadmap of reforming the system of sociomedical assessment Ukraine's
Mykychak , I.V.
Ministry of Health of Ukraine, Hrushevskoho str., 7 , Kyiv, 01601
Perepelychna, R.Ya.
Ministry of Health of Ukraine, Hrushevskoho str., 7 , Kyiv, 01601
Borysova , I.S.
Dnipro State Medical University, V. Vernadsky str., 9, Dnipro, 49044 https://orcid.org/0000-0003-4703-6046
Roadmap of reforming the system of sociomedical assessment Ukraine's
Dnipro State Medical University
2022-04-05 14:37:47
application/pdf
application/pdf
https://journals.uran.ua/index.php/2307-0404/article/view/254472
Medicni perspektivi; Vol. 27 No. 1 (2022)
eng
##submission.copyrightStatement##