The state of some cytokines in measles in children
DOI:
https://doi.org/10.22141/2312-413x.7.4.2019.178880Keywords:
measles, cytokines, children, InflucidAbstract
According to the Public Health Center of Ukraine, from the beginning of the year (from December 28, 2018, to June 27, 2019), 55,300 people had measles, including 25,987 adults and 29,313 children, and 18 persons died from complications of measles. During the outbreak since summer 2017, more than 110 thousand people were ill with measles, 39 of whom died. Symptomatic and supportive treatment of measles is required. The purpose of the research is to reveal the peculiarities of cytokine status in children with measles and to make the correction with a combined homoeopathic drug Influcid. Materials and methods. Surveillance was carried out for 97 children aged from 3 weeks to 18 years who suffered from measles and underwent inpatient treatment. In children with measles at the onset of the disease and in the dynamics, changes of the cytokine profile were marked. They manifested themselves in an imbalance of proinflammatory and anti-inflammatory cytokines that indicated antiviral defense tension in measles. Treatment of patients was carried out according to local protocols. Children of the study group (n = 45) received Influcid from the first day of inpatient treatment in addition to standard therapy. As a result of the drug use, there was a reduction in the duration of fever by 2.8 days and catarrhal syndrome — by 5.4 days, as well as the normalization of cytokine status.References
Інфекційні хвороби в дітей. За ред. професора С.О. Крамарьова і професора О.Б. Надраги. К.: Медицина, 2010. 392 с.
Бектимиров Т.А. Стратегия ВОЗ по глобальной ликвидации кори. Вакцинация. 2002. № 5 (23). С. 4-5.
Чудна Л.М. Епідемічна ситуація з кору в Україні за 2002–2006 рр. Вчення Л.В. Громашевського в сучасних умовах боротьби з інфекційними хворобами: матеріали доповідей наук.-практ. конф. К., 2006. С. 133-138.
Мойсеєва А.В., Васильєва В.А., Кондрашова Н.С., Новик Л.В. Корова інфекція і її профілактика на сучасному етапі. Перинатология и педиатрия. 2009. № 4. С. 68-71.
Громашевский Л.В. Особенности эпидемиологии «детских» инфекций. Детские инфекции. Киев: Здоровье, 1958. С. 5-27.
Малий В.П. Сучасні проблеми кору: клінічна картина, діагностика та лікування. Клиническая иммунология. Аллергология. Инфектология. 2012. № 1–2. С. 10-17.
Дополнительная информация по безопасности вакцин. Департамент вакцин и биологических препаратов. Женева: ВОЗ, 2008.
Formi A.L., Schluger N.W., Roberts R.S. Severe measles pneumonitis in adults: evalution clinical characteristics and therapy with intravenous ribavirin. Clin. Infect. Dis. 1994. № 19. P. 454-462.
Мойсеєва Г.В. Вплив імунопрофілактики на епідемічний процес кору. Здоровье ребенка. 2010. № 3. С. 89-92.
Айдаралієва Ч.Х. Перспективи елімінації кору в Україні. СЕС. 2005. С. 56.
Чуклин С.Н., Переяслов А.А. Интерлейкины. Львов: Лига-Пресс, 2005. 481 с.
Фролов В.М., Лоскутова И.В. Эффективность нуклеината при иммунокоррекции ветряной оспы. Украинский медицинский альманах. 2008. № 4. С. 170-174.
Москаленко В.Ф., Гульчій О.П., Голубчиков М.В., Лєдощук Б.О., Лєхан В.М., Огнєв В.А., Литвинова Л.О., Максименко О.П., Тонковид О.Б. / За загальною редакцією члена-кореспондента АМН України, професора В.Ф. Москаленка. Біостатистика. К.: Книга плюс, 2009. 184 с. http://www.drlz.com.ua
Инструкция по применению Инфлюцида. http://www.drlz.com.ua.
Downloads
Published
Issue
Section
License
Copyright (c) 2019 ACTUAL INFECTOLOGY
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
- The rights to the article are deemed transferred by the authors to the edition (the publisher) since the moment of the publication of the article in the printed or electronic version of journal.
