Ovarian suppression in breast cancer management


  • O.S. Zotov Bogomolets National Medical University, Kyiv, Ukraines,




breast cancer, endocrine therapy, ovarian suppression, review


The review summarizes current data about the role of ovarian suppression/ablation in endocrine therapy for breast cancer. Information of the indications and methods of ovarian suppression is given; the characteristics of modern drugs used for this purpose — gonadotropin-releasing hormone agonist — are presented, including their advantages and possible side effects. The review contains a description of the evolution of views on the indications for ovarian suppression based on the data from the most authoritative and reliable clinical trials. The latest data from leading international guidelines on the scope of ovarian suppression/ablation in the palliative, adjuvant and neoadjuvant modes are discussed.


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