Glutathione system — a promising target for increasing sensitivity to chemotherapeutic drugs (literature review)


  • A.V. Postupalenko Bogomolets National Medical University, Kyiv, Ukraine,
  • Yu.I. Zaivelieva Bogomolets National Medical University, Kyiv, Ukraine,
  • O.S. Zotov Bogomolets National Medical University, Kyiv, Ukraine,



redox potential, glutathione, malignant neoplasms, antitumor therapy, overview


The review considers the role of the glutathione system in the context of the treatment for malignant neoplasms that has been actively studied for several decades. Its functioning is vital for maintaining the redox homeostasis of normal cells of the human body; at the same time, numerous correlations of this system with the development and progression of malignant neoplasms are established. Given the important role of glutathione in cell death and development of resistance to chemotherapeutic compounds, a further search for levers of influence on glutathione-mediated mechanisms is promising.


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