Combined treatment of colorectal cancer patients with resectable metastases (professional experience)

Authors

  • V.V. Boyko State Institution “V.T. Zaytsev Institute of General and Urgent Surgery of the National Academy of Medical Sciences of Ukraine”, Kharkiv, Ukraine,
  • S.A. Savvi State Institution “V.T. Zaytsev Institute of General and Urgent Surgery of the National Academy of Medical Sciences of Ukraine”, Kharkiv, Ukraine,
  • A.B. Starikova State Institution “V.T. Zaytsev Institute of General and Urgent Surgery of the National Academy of Medical Sciences of Ukraine”, Kharkiv, Ukraine,
  • V.V. Zhydetskyy State Institution “V.T. Zaytsev Institute of General and Urgent Surgery of the National Academy of Medical Sciences of Ukraine”, Kharkiv, Ukraine,
  • A.Yu. Korolevskaya State Institution “V.T. Zaytsev Institute of General and Urgent Surgery of the National Academy of Medical Sciences of Ukraine”, Kharkiv, Ukraine,

DOI:

https://doi.org/10.22141/2663-3272.2.2.2019.176030

Keywords:

metastatic colorectal cancer, combined treatment, resectable metastases

Abstract

The article presents the results of combined treatment of 34 patients with resectable colorectal cancer metastases. In the first phase, all patients underwent surgical treatment. In the second one, they underwent from 3 to 6 cycles of FOLFOX chemotherapy. The optimal or suboptimal cytoreduction leads to a maximum reduction of tumor burden, which allows not only to increase life expectancy of patients, but also to improve its quality due to the emergence of intervals without systemic chemotherapy.

References

Патютко Ю.И. Современные подходы к лечению метастазов колоректального рака в печени. Вестник хирургической гастроэнтерологии. 2008. № 4. С. 14-28.

Ferrand F. Impact of primary tumor resection on survival of patients with colorectal cancer and synchronous metastases treated by chemotherapy: results from the multicenter, randomized trial Fede­ration Francophone de Cancerologie Degestive 9601. Eur. J. Cancer. 2013. Vol. 49. № 1. P. 90-97.

Folprecht G. Neoadjuvant therapy concepts for liver metastases. Chirurg. 2011. Vol. 82. № 11. P. 989-994.

Kato T. Therapeutic results for heratic metastasis of colorectal cancer with special reference of effectiveness of hepatectomy: analysis of prognostic factors for 763 cases recorded at 18 institution. Dis. Col. Rec. 2003. Vol. 49. P. 22-31.

Schmooll H.J. ESMO Consensus Guidelines for anagement of patients with colon and rectal cancer. A personalized approach to clini­cal decision marin. Ann. Oncol. 2012. Vol. 23. № 10. P. 2479-2516.

Siegel R. Cancer statistics. CA Cancer J. Clin. 2012. Vol. 62. P. 10-29.

Weiser M. Peri-operative chemotherapy for the treatment of resec­table liver metastases from colorectal cancer: A systematic review and meta-analysis of randomized trials. BMC Cancer. 2010. Vol. 21. № 10. P. 309.

Issue

Section

Practicing Physician