Characteristics of hematological and biochemical parameters in patients with stage IIB–IIIB breast cancer with late radiation complications

Authors

  • F.V. Hladkykh SO “Grigoriev Institute for Medical Radiology and Oncology of the National Academy of Medical Sciences of Ukraine”, Kharkiv, Ukraine,
  • H.V. Kulinich SO “Grigoriev Institute for Medical Radiology and Oncology of the National Academy of Medical Sciences of Ukraine”, Kharkiv, Ukraine, https://orcid.org/0000-0002-0636-9621
  • V.S. Sevastianova SO “Grigoriev Institute for Medical Radiology and Oncology of the National Academy of Medical Sciences of Ukraine”, Kharkiv, Ukraine,

DOI:

https://doi.org/10.22141/2663-3272.3.1.2020.209819

Keywords:

breast cancer, radiation therapy, late radiation complications

Abstract

The aim of the work is to conduct a comparative analysis of the values of initial hematological and biochemical parameters of patients with breast cancer of stages IIB–IIB with and without late radiation complications (LRC). Materials and methods. There was performed a retrospective analysis of 81 medical histories of female patients with breast cancer (45 patients with LRC and 36 patients without LRC after radiation therapy) who received in-patient treatment at Grigoriev Institute for Medical Radiology and Oncology of the NAMN of Ukraine for the period 1994–2018, including radiation therapy. Two groups of patients with stage IIIB–IIIB breast cancer were formed: I (23 patients with LRC) and II (22 patients without LRC). Results. Characterizing the hematologic indices of patients with IIB–IIIB stages breast cancer, it should be noted that patients with LRC after radiation therapy were found to have decreased (p = 0.1) red blood cell count by 6.7 % (3.80 ± 0.11 × 1012/l) and decreased hemoglobin level (p = 0.09) by 6.1 % (of 114.50 ± 2.53 g/l) compared to baseline values. The analysis of biochemical indicators showed that patients with stage IIIB–IIIB breast cancer with LRC had higher values of total protein (by 9.9 %, p = 0.04), bilirubin (by 6.2 %, p = 0.5), glucose (by 9.1, p = 0.09) and aminotransferases (ALT by 8.6 %, p = 0.4, ASAT by 31.9, р = 0.005) compared to the values of patients in the control group. When evaluating the indicators of the blood clotting system, it should be noted that patients with stage IIIB–IIIB breast cancer with LRC had a higher clotting time (p = 0.4) by 17.9 % and a statistically significantly (p = 0.03) higher level of fibrinogen by 23.3 %. Conclusions. It was found that 78.30 ± 0.09 % of patients with IIIB–IIIB breast cancer with LRC were diagnosed with inflammatory changes, 47.8 ± 0.10 % of patients — with fibrotic, 13.00 ± 0.07 % of patients — with hematological and 4.30 ± 0.04 % — with degenerative changes. It was found that in the structure of concomitant diseases in patients with stage III–III breast cancer, cardiovascular diseases (78.0–84.4%), diseases of the digestive system (33.3–44.4 %) and nervous system (36.1–42.2 %) are most often diagnosed. It was shown that the initial level of hematocrit was higher among the hematological indicators in patients with stage IIIB–IIIB breast cancer with LRC (37.0 [34.8; 38.4] %) (p = 0.09) by 9.7 %, the content of white blood cells (5.8 [4.8; 6.5] × 109/l) was higher (p = 0.1) by 6.1 %, and ESR (16 [6; 18] mm/h) was higher (p = 0.1) by 60.0 % compared to the baseline parameters of patients without LRC. The analysis of biochemical indicators showed that patients with stage IIIB–IIIB breast cancer with LRC had higher values of total protein (by 9.9 %, p = 0.04), bilirubin (by 6.2 %, p = 0.5), glucose (by 9.1, p = 0.09) and aminotransferases (ALT by 8.6 %, p = 0.4, ASAT by 31.9, р = 0.005) compared to the values of patients without LRC.

References

Гайсенюк Л.О., Аміразян С.А., Толкачов Ю.А. Стан кардіальної системи в онкологічних хворих у віддалений термін після променевого та комплексного лікування. Український радіологічний журнал. 2004. Т. ХІІ. Вип. 2. С. 154-157.

Гайсенюк Л.О., Кулініч Г.В., Мороз В.А. Клініко-рентгенологічна семіотика пізніх променевих ускладнень легень у онкологічних хворих. Український радіологічний журнал. 2003. Т. XI. Вип. 2.

С. 164-166.

Криворотько П.В., Зернов К.Ю., Дашян Г.А., Комяхов А.В. и др. Влияние системной и лучевой терапии на осложнения при онкопластической хирургии рака молочной железы. Вопросы онкологии. 2018. Т. 64. № 3. С. 298-302.

Криворотько П.В., Зернов К.Ю., Дашян Г.А., Новиков С.Н., Жильцова Е.К., Комяхов А.В. и др. Место и время лучевой терапии у больных раком молочной железы после реконструктивных операций. Злокачественные опухоли. 2018. № 3. С. 22-26.

Лечение рака молочной железы: клинико-биологическое обоснование. Под ред. Семиглазова В.Ф., Семиглазова В.В. М.: СИМК, 2017. 272 с.

Рак в Україні, 2017–2018. Захворюваність, смертність, показники діяльності онкологічної служби. За ред. Колеснік О.О. К., 2019. 101 с.

Роздільський С.І., Гайсенюк Л.О., Мороз В.А. Діагностика та лікування ранніх променевих ускладнень. Методичні рекомендації. Харків, 2002. 25 с.

Савченко А.С. Непосредственные и отдаленные результаты профилактики и лечения нарушений состояния сердечно-сосудистой системы у больных раком грудной железы и сопутствующей кардиологической патологией. Проблеми медичної науки та освіти. 2007. № 4. С. 80-83.

Смоланка І.І., Іванкова В.С., Скляр С.Ю., Іванкова О.М. Застосування модифікаторів — шлях до підвищення ефективності лікування хворих на первинно неоперабельний рак грудної залози. Клінічна онкологія. 2012. № 6(2). С. 38-43.

Сорочан П.П., Громакова И.А., Сухина Е.Н., Прохач Н.Э., Громакова И.С. Роль цитокинов в развитии гематологических осложнений у больных онкологического профиля. Клиническая онкология. 2015. № 2(18). С. 34-37.

Топузов Э.Э., Агишев Т.Т., Божок А.А., Дашян Г.А., Садыгова С.Н., Приходько Е.В., Аршба Э.А. Клинико-морфологическая характеристика повреждений кожи и подкожно-жировой клетчатки после хирургического лечения и лучевой терапии у больных раком молочной железы (обзор литературы). Маммология. 2017. Т. 13. № 21. С. 25-33.

Уніфікований клінічний протокол первинної, вторинної (спеціалізованої), третинної (високоспеціалізованої) медичної допомоги «Рак молочної залози» (Наказ МОЗ України від 30 червня 2015 р. № 396). Медичні аспекти здоров’я жінки. 2015. № 8(94). С. 41-74.

Coles C.E. Reduction of radiotherapy-induced late complications in early breast cancer: the role of intensity-modulated radiation therapy and partial breast irradiation: part II-radiotherapy strategies to reduce radiation-induced late effects. Clinical oncology. 2005. Vol. 17. № 2. P. 98-110.

Collette S., Collette L., Budiharto T. Predictors of the risk of fibrosis at 10 years after breast conserving therapy for early breast cancer: a study based on the EORTC Trial 22881-10882 ‘boost versus no boost. Eur. J. Cancer. 2008. Vol. 44. № 17. P. 2587-2599.

See M.S.F., Farhadi J. Radiation Therapy and Immediate Breast Reconstruction: Novel Approaches and Evidence Base for Radiation Effects on the Reconstructed Breast. Clinics in Plastic Surgery. 2017.

Zar J.H. Biostatistical analysis. 5 ed. Prentice-Hall, Englewood. 2014. 960 р.

Downloads

Published

2020-02-01

Issue

Vol. 3 No. 1 (2020)

Section

Original Researches

License

Copyright (c) 2020 Practical oncology

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Our edition uses the copyright terms of Creative Commons for open access journals.

Authors, who are published in this journal, agree with the following terms:

  1. The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
  2. Directing  the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
  3. The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
  4. The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
  5. The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
  6. The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
  7. The rights to the article are deemed transferred by the authors to the edition (the publisher) since the moment of the publication of the article in the printed or electronic version of journal.