Anticancer chemotherapy with high-dose methotrexate
DOI:
https://doi.org/10.22141/2663-3272.4.1.2021.229869Keywords:
methotrexate, high-dose cytotoxic chemotherapy, osteosarcoma, primary central nervous system diffuse large B-cell lymphoma, acute lymphoblastic leukemia, reviewAbstract
The literature review is devoted to the use of high doses of methotrexate in oncology. There is a brief historical overview of the use of methotrexate for the treatment of malignant neoplasms; the main mechanism of its cytotoxic effect on tumor cells, the development of resistance to methotrexate, the main indications for the use of high doses of methotrexate and the main side effects of this treatment are considered. The review details the results of using high doses of methotrexate in the treatment of patients with osteosarcoma, non-Hodgkin’s lymphomas, located mainly in the central nervous system, and acute lymphoblastic leukemia.
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