Marina Carini

Marina Carini E-mail
University of Milan, Италия

Professor

Department of Pharmaceutical Sciences – Faculty of Pharmacy

 

Профиль Scopus: ссылка

ID ORCID: http://orcid.org/0000-0003-3407-5425

Marina Carini has gained a long-standing expertise in the following main fields: pharmaceutical, biopharmaceutical and biomedical analysis; toxicological chemistry; chemistry of free radicals and reactive carbonyl species (RCS) generated by lipid peroxidation; chemical and biochemical mechanisms of action of antioxidants and of RCS-sequestering agents; development of bioanalytical methods to detect free radical-mediated oxidative/carbonyl damage in cells, plasma and tissues; peptidomics and proteomics by mass spectrometric approaches. Owing to the availability of suitable and innovative instrumentation, the research of the last years has been focused on the development and application of mass spectrometric methods (LC-MS/MS) to identify new compounds (natural or synthetic) able to trap and detoxify RCS, and in proteomics, to study covalently-modified proteins and ligand-protein interactions.

 

Основные публикации:

1. Garzon, D. Spectrometric Strategies for the Identification and Characterization of Human Serum Albumin Covalently Adducted by Amoxicillin: Ex Vivo Studies [Text] / D. Garzon, A. Ariza, L. Regazzoni, R. Clerici, A. Altomare, F. R. Sirtori, Carini, M. et. al // Chemical Research in Toxicology. – 2014. – Vol. 27, Issue 9. – P. 1566–1574. doi: 10.1021/tx500210e

2. Aldini, G. Novel molecular approaches for improving enzymatic and nonenzymatic detoxification of 4-hydroxynonenal: toward the discovery of a novel class of bioactive compounds [Text] / G. Aldini, M. Carini, K.-J. Yeum, G. Vistoli // Free Radical Biology and Medicine. – 2014. – Vol. 69. – P. 145–156. doi: 10.1016/j.freeradbiomed.2014.01.017

3. Colzani, M. A novel high resolution MS approach for the screening of 4-hydroxy-trans-2-nonenal sequestering agents [Text] / M. Colzani, A. Criscuolo, D. De Maddis, D. Garzon, K.-J. Yeum, G. Vistoli, M. Carini, G. Aldini // Journal of Pharmaceutical and Biomedical Analysis. – 2014. – Vol. 91. – P. 108–118. doi: 10.1016/j.jpba.2013.12.024

4. Bertoletti, L. Advanced glycation end products of beta2-microglobulin in uremic patients as determined by high resolution mass spectrometry [Text] / L. Bertoletti, L. Regazzoni, A. Altomare, R. Colombo, M. Colzani, G. Vistoli, L. Marchese, M. Carini, G. Aldini // Journal of Pharmaceutical and Biomedical Analysis. – 2014. – Vol. 91. – P. 193–201. doi: 10.1016/j.jpba.2013.12.021

5. Colzani, M. Mass spectrometric approaches for the identification and quantification of reactive carbonyl species protein adducts [Text] / M. Colzani, G. Aldini, M. Carini // Journal of Proteomics. – 2013. – Vol. 92. – P. 28–50. doi: 10.1016/j.jprot.2013.03.030

6. Vistoli, G. Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation [Text] / G. Vistoli, D. De Maddis, A. Cipak, N. Zarkovic, M. Carini, G. Aldini // Free Radical Research. – 2013. – Vol. 47, Issue S1. – P. 3–27. doi: 10.3109/10715762.2013.815348

7. Vistoli, G. Exploring the space of histidine containing dipeptides in search of novel efficient RCS sequestering agents [Text] / G. Vistoli, D. De Maddis, V. Straniero, A. Pedretti, M. Pallavicini, E. Valoti, M. Carini, B. Testa, G. Aldini // European Journal of Medicinal Chemistry. – 2013. – Vol. 66. – P. 153–160. doi: 10.1016/j.ejmech.2013.05.009