DOI: https://doi.org/10.15587/2313-8416.2014.27623

Design of experiment in the synthesis optimization of vancomycin-selective "artificial receptors"

Екатерина Николаевна Музыка

Abstract


The work is focused on the use of chemometric approach to "design of experiment", implemented using MODDE 9.0 software package to optimize the synthesis of the vancomycin-selective nanoparticles ("artificial receptor" based on molecularly imprinted polymers) in an automatic reactor in order to obtain its maximum quantitative yield.


Keywords


molecularly imprinted polymer; artificial receptors; vancomicine; affinity; design of experiment

References


1. Moreno-Bondi, M. C., Benito-Peña, M. E., Urraca, J. L., Orellana, G. (2012). Immuno-Like Assays and Biomimetic Microchips. Top Curr. Chem, 325, 111–164. http://dx.doi.org/10.1007/128_2010_94

2. Muzyka, K. (2014). Current Trends in the Development of the Electrochemiluminescent Immunosensors. Biosensors and Bioelectronics, 54, 393–407. http://dx.doi.org/10.1016/j.bios.2013.11.011

3. Poma, A., Guerreiro, A., Whitcombe, M. J., Piletska E.V., Turner A.P.F. and Piletsky, S. A. (2013). Solid-Phase Synthesis of Molecularly Imprinted Polymer Nanoparticles with a Reusable Template – “Plastic Antibodies”. Advanced Functional Materials, 23 (22), 2821–2827. http://dx.doi.org/10.1002/adfm.201202397

4. Leardi, R. (2009) Experimental design in chemistry: A tutorial. Analytica Chimica Acta, 652 (2), 161–172. http://dx.doi.org/10.1016/j.aca.2009.06.015

5. Nicholls, I. A., Andersson, H. S., Golker, K., Henschel, H., Karlsson, B. C. G., Olsson, G. D., Wikman, S. (2011). Rational design of biomimetic molecularly imprinted materials: theoretical and computational strategies for guiding nanoscale structured polymer development. Analytical and Bioanalytical Chemistry, 400 (6), 1771–1786. http://dx.doi.org/10.1007/s00216-011-4935-1

6. Muzyka, K., Karim, K., Guerreiro, A., Poma A., Piletsky, S. (2014). Optimisation of the synthesis of vancomycin-selective molecularly imprinted polymer nanoparticles using automatic photoreator. Nanoscale Research Letters, 9 (1), 154–161. http://dx.doi.org/10.1186/1556-276x-9-154


GOST Style Citations


1. Moreno-Bondi, M. C. Immuno-Like Assays and Biomimetic Microchips [Text] /  M. C. Moreno-Bondi, M. E. Benito-Peña, J. L. Urraca, G. Orellana // Top Curr. Chem. – 2012. – Vol. 325. – P. 111–164. http://dx.doi.org/10.1007/128_2010_94 

2. Muzyka, K. Current Trends in the Development of the Electrochemiluminescent Immunosensors [Text] / K. Muzyka // Biosensors and Bioelectronics. – 2014. – Vol. 54. – P. 393–407. http://dx.doi.org/10.1016/j.bios.2013.11.011 

3. Poma, A. Solid-Phase Synthesis of Molecularly Imprinted Polymer Nanoparticles with a Reusable Template – “Plastic Antibodies” [Text] / A. Poma, A. Guerreiro, M. J. Whitcombe, E.V. Piletska, A.P.F. Turner and S. A. Piletsky // Advanced Functional Materials. – 2013. – Vol. 23, Issue 22. – P.2821–2827. http://dx.doi.org/10.1002/adfm.201202397 

4. Leardi, R. Experimental design in chemistry: A tutorial [Text] / R. Leardi // Analytica Chimica Acta. – 2009. – Vol. 652, Issue 2. – P.161-172. http://dx.doi.org/10.1016/j.aca.2009.06.015 

5. Nicholls, I. A. Rational design of biomimetic molecularly imprinted materials: theoretical and computational strategies for guiding nanoscale structured polymer development [Text] / I. A. Nicholls, H. S. Andersson, K. Golker, H. Henschel, B. C. G. Karlsson, G. D. Olsson, S. Wikman // Analytical and Bioanalytical Chemistry . – 2011. – Vol. 400, Issue 6. – P. 1771–1786. http://dx.doi.org/10.1007/s00216-011-4935-1 

6. Muzyka, K. Optimisation of the synthesis of vancomycin-selective molecularly imprinted polymer nanoparticles using automatic photoreator [Text] K. Muzyka, K. Karim, A. Guerreiro, A. Poma and S. Piletsky // Nanoscale Research Letters. – 2014. – Vol. 9, Issue 1. – P. 154–161. http://dx.doi.org/10.1186/1556-276x-9-154 







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