Modelling of toxic liver damage on line ICR mice
DOI:
https://doi.org/10.15587/2313-8416.2014.29151Keywords:
mouse line ICR, liver necrosis, fibrosis, cirrhosis, cancer, CCl4, ALT, AST, ultrasoundAbstract
Cirrhosis is severe complications of liver disease. Using animals with synthetically induced 30% oil solution of CCl4-induced liver injury enables deeper study morphological and functional changes of the body. Using biochemical, cytological, histological, radiological and morphometric methods, we have found that in the liver of experimental male-ICR mice with a model of liver damage observed profound changes with subsequent development of irreversible tumors.
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Copyright (c) 2014 Марія Валеріївна Драгулян, Тамара Павлівна Гулько, Віталій Арнольдович Кордюм, Ростислав Володимирович Бубнов, Олена Григорівна Дерябіна
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