DOI: https://doi.org/10.15587/2313-8416.2014.34227

Исследование токсичности наночастиц золота и алмазов

Наталия Федоровна Беляева, Константин Владимирович Золотарёв, Валентина Николаевна Каширцева, Оксана Сергеевна Дружиловская, Дамир Вячеславович Игнатов, Ольга Михайловна Ипатова, Марина Викторовна Михайлова

Аннотация


Проведено исследование токсичности наночастиц золота и алмазов на ранних стадиях развития зебрафиш (Danio rerio). Токсического действия нанозолота выявлено не было. В то же время, действие наноалмазов в течение 7 суток вызывало как летальные эффекты (LC50=104±18 мг/л), так и отклонения в развитии.


Ключевые слова


наночастицы ; наноалмазы ; нанозолото ; токсические эффекты ; модельные системы ; зебрафиш ; эмбрионы ; личинки

Полный текст:

PDF

Литература


Kolesnichenko, A. V., Timofeev, M. A., Protopopova, M. V. (2008). Toxicity of nanomaterials – 15 years of research. Rossiiskie Nanotekhnologii, 58 (3-4), 54–61.

Fako, V. E., Furgeson, D. Y. (2009). Zebrafish as a correlative and predictive model for assessing biomaterial nanotoxicity. Advanced Drug Delivery Reviews, 61 (6), 478–486. doi: 10.1016/j.addr.2009.03.008

Huff, T. B., Tong, L., Zhao, Y., Hansen, M. N., Cheng, J. X., Wei, A. (2007). Hyperthermic effects of gold nanorods on tumor cells. Nanomedicine, 2 (1), 125–132. doi: 10.2217/17435889.2.1.125

Dreaden, E. C., Mackey, M. A., Huang, X., Kang, B., El-Sayed, M. A. (2011). Beating cancer in multiple ways using nanogold. Chemical Society Reviews, 40 (7), 3391–3404. doi: 10.1039/c0cs00180e

Huang, X., Jain, P. K., El-Sayed, I. H., El-Sayed, M. A. (2007). Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy. Nanomedicine (Lond), 2 (5), 681–693. doi: 10.2217/17435889.2.5.681

Belyaeva, N. F., Kashirtseva, V. N., Medvedeva, N. V., Khudoklinova, Y. Y., Ipatova, O. M., Archakov, A. I. (2009). Zebrafish as a model system for biomedical studies. Biochemistry (Moscow) Suppl. B: Biomedical Chemistry, 3 (4), 343–350. doi: 10.1134/s1990750809040039

Zolotarev, K. V., Kashirtseva, V. N., Mishin, A. V., Belyaeva, N. F., Medvedeva, N. V., Ipatova, O. M. (2012). Assessment of Toxicity of Cdse/Cds/Zns/S,S-Dihydrolipoic Acid/Polyacrylic Acid Quantum Dots at Danio rerio Embryos and Larvae. ISRN Nanotechnology, 2012, 1–5. doi: 10.5402/2012/914636

Kovrižnych, J. A., Sotníková, R., Zeljenková, D., Rollerová, E., Szabová, E., Wimmerová, S. (2013). Acute toxicity of 31 different nanoparticles to zebrafish (Danio rerio) tested in adulthood and in early life stages – comparative study. Interdisciplinary Toxicology, 6 (2), 67–73. doi: 10.2478/intox-2013-0012

Lee, K. J., Nallathamby, P. D., Browning, L. M., Osgood, C. J., Xu, X. N. (2007). In vivo imaging of transport and biocompatibility of single silver nanoparticles in early development of zebrafish embryos. ACS Nano, 1 (2), 133–144. doi: 10.1021/nn700048y

Rizzo, L. Y., Golombek, S. K., Mertens, M. E., Pan Y., Laaf D., Broda, J., Jayapaul, Möckel, J. D., Subr, V., Hennink, W. E., Storm, G., Simon, U., Jahnen-Dechent, W.,. Kiessling, F, Lammers, T. (2013). In Vivo Nanotoxicity Testing using the Zebrafish Embryo Assay. Journal of Materials Chemistry B, 1, Issue 32. – P. 3918. doi: 10.1039/c3tb20528b

Browning, L. M., Huang, T., Xu, X. H. (2013). Real-time in vivo imaging of size-dependent transport and toxicity of gold nanoparticles in zebrafish embryos using single nanoparticle plasmonic spectroscopy. Interface Focus, 3 (3), 20120098. doi: 10.1098/rsfs.2012.0098

García-Cambero, J. P., Núñez García, M., López, G. D., Herranz, A. L., Cuevas, L., Pérez-Pastrana, E., Cuadal, J. S., Castelltort, M. R., Calvo, A. C. (2013). Converging hazard assessment of gold nanoparticles to aquatic organisms. Chemosphere, 93 (6), 1194–1200. doi: 10.1016/j.chemosphere.2013.06.074

Bar-Ilan, O. R., Albrecht, M., Fako, V. E., Furgeson, D. Y. (2009). Toxicity Assessments of Multisized Gold and Silver Nanoparticles in Zebrafish Embryos. Small, 5 (16), 1897–1910. doi: 10.1002/smll.200801716

Asharani, P. V., Lianwu, Y., Gong, Z., Valiyaveettil, S. (2011). Comparison of the toxicity of silver, gold and platinum nanoparticles in developing zebrafish embryos. Nanotoxicology, 5 (1), 43–54. doi: 10.3109/17435390.2010.489207

ISO. (1996). Water quality – Determination of the acute lethal toxicity of substances to a freshwater fish [Brachydanio rerio Hamilton-Buchanan (Teleostei, Cyprinidae)] – Part 3: Flow-through method. ISO 7346-3:1996, 11.

OECD. (2006). Guideline for the testing of chemicals. Fish Embryo Toxicity (FET) Test. Draft proposal for a new guideline, 11.

Kim, K. T., Zaikova, T., Hutchison, J. E., Tanguay, R. L. (2013). Gold nanoparticles disrupt zebrafish eye development and pigmentation. Toxicological Sciences, 133 (2), 275–288. doi: 10.1093/toxsci/kft081


Пристатейная библиография ГОСТ


1. Колесниченко, А. В. Токсичность наноматериалов – 15 лет исследований [Текст] / А. В. Колесниченко, М. А. Тимофеев, М. В. Протопопова // Российские нанотехнологии. – 2008. – T. 58, № 3-4. – С. 54–61.

2. Fako, V. E. Zebrafish as a correlative and predictive model for assessing biomaterial nanotoxicity [Text] / V. E. Fako, D. Y. Furgeson // Advanced Drug Delivery Reviews. – 2009. – Vol. 61, Issue 6. – P. 478–486. doi: 10.1016/j.addr.2009.03.008 

3. Huff, T. B. Hyperthermic effects of gold nanorods on tumor cells [Text] / T. B. Huff, L. Tong, Y. Zhao, M. N. Hansen, J. X. Cheng, A. Wei // Nanomedicine. – 2007. – Vol. 2, Issue 1. – P. 125–132. doi: 10.2217/17435889.2.1.125 

4. Dreaden, E. C. Beating cancer in multiple ways using nanogold [Text] / E. C. Dreaden, M. A. Mackey, X. Huang, B. Kang, M. A. El-Sayed // Chemical Society Reviews. – 2011. – Vol. 40, Issue 7. – P. 3391–3404. doi: 10.1039/c0cs00180e 

5. Huang, X. Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy [Text] / X. Huang, P. K. Jain, I. H. El-Sayed, M. A. El-Sayed // Nanomedicine. – 2007. – Vol. 2, Issue 5. – P. 681–693. doi: 10.2217/17435889.2.5.681 

6. Belyaeva, N. F. Zebrafish as a model system for biomedical studies [Text] / N. F. Belyaeva, V. N. Kashirtseva, N. V. Medvedeva, Y. Y. Khudoklinova, O. M. Ipatova, A. I. Archakov // Biochemistry (Moscow) Suppl. B: Biomedical Chemistry. – 2009. – Vol. 3, Issue 4. – P. 343–350. doi: 10.1134/s1990750809040039 

7. Zolotarev, K. V. Assessment of Toxicity of Cdse/Cds/Zns/S,S-Dihydrolipoic Acid/Polyacrylic Acid Quantum Dots at Danio rerio Embryos and Larvae [Text] / K. V. Zolotarev, V. N. Kashirtseva, A. V. Mishin, N. F. Belyaeva, N. V. Medvedeva, O. M. Ipatova // ISRN Nanotechnology. – 2012. – Vol. 2012. – P. 1–5. doi: 10.5402/2012/914636 

8. Kovrižnych, J. A. Acute toxicity of 31 different nanoparticles to zebrafish (Danio rerio) tested in adulthood and in early life stages - comparative study [Text] / J. A. Kovrižnych, R. Sotníková, D. Zeljenková, E. Rollerová, E. Szabová, S. Wimmerová // Interdisciplinary Toxicology. – 2013. – Vol. 6, Issue 2. – P. 67–73. doi: 10.2478/intox-2013-0012

9. Lee, K. J. In vivo imaging of transport and biocompatibility of single silver nanoparticles in early development of zebrafish embryos [Text] / K. J. Lee, P. D. Nallathamby, L. M. Browning, C. J. Osgood, X. N. Xu // ACS Nano. – 2007. – Vol. 1, Issue 2. – P. 133–144. doi: 10.1021/nn700048y 

10. Rizzo, L. Y. In Vivo Nanotoxicity Testing using the Zebrafish Embryo Assay [Text] / L. Y. Rizzo, S. K. Golombek, M. E. Mertens, Y. Pan, D. Laaf, J. Broda, J. Jayapaul, D. Möckel, V. Subr, W. E. Hennink, G. Storm, U. Simon, W. Jahnen-Dechent, F. Kiessling, T. Lammers // Journal of Materials Chemistry B. – 2013. – Vol. 1, Issue 32. – P. 3918. doi: 10.1039/c3tb20528b 

11. Browning, L. M. Real-time in vivo imaging of size-dependent transport and toxicity of gold nanoparticles in zebrafish embryos using single nanoparticle plasmonic spectroscopy [Text] / L. M. Browning, T. Huang, X. H. Xu // Interface Focus. – 2013. – Vol. 3, Issue 3. – P. 20120098. doi: 10.1098/rsfs.2012.0098

12. García-Cambero, J. P. Converging hazard assessment of gold nanoparticles to aquatic organisms [Text] / J. P. García-Cambero, M. Núñez García, G. D. López, A. L. Herranz, L. Cuevas, E. Pérez-Pastrana, J. S. Cuadal, M. R. Castelltort, A. C. Calvo // Chemosphere. – 2013. – Vol. 93, Issue 6. – P. 1194–1200. doi: 10.1016/j.chemosphere.2013.06.074

13. Bar-Ilan, O. R. Toxicity Assessments of Multisized Gold and Silver Nanoparticles in Zebrafish Embryos [Text] / O. R. Bar-Ilan, M. Albrecht, V. E. Fako, D. Y. Furgeson // Small. – 2009. – Vol. 5, Issue 16. – P. 1897–1910. doi: 10.1002/smll.200801716 

14. Asharani, P. V. Comparison of the toxicity of silver, gold and platinum nanoparticles in developing zebrafish embryos [Text] / P. V. Asharani, Y. Lianwu, Z. Gong, S. Valiyaveettil // Nanotoxicology. – 2011. – Vol. 5, Issue 1. – P. 43–54. doi: 10.3109/17435390.2010.489207

15. ISO. Water quality – Determination of the acute lethal toxicity of substances to a freshwater fish [Brachydanio rerio Hamilton-Buchanan (Teleostei, Cyprinidae)] Part 3: Flow-through method [Text] / ISO // ISO 7346-3:1996, 1996. – 11 p.

16. OECD. Guideline for the testing of chemicals. Fish Embryo Toxicity (FET) Test [Text] / OECD Draft proposal for a new guideline, 2006. – 11 p.

17. Kim, K. T. Gold nanoparticles disrupt zebrafish eye development and pigmentation [Text] / K. T. Kim, T. Zaikova, J. E. Hutchison, R. L. Tanguay // Toxicological Sciences. – 2013. – Vol. 133, Issue 2. – P. 275–288. doi: 10.1093/toxsci/kft081







Copyright (c) 2014 Наталия Федоровна Беляева, Константин Владимирович Золотарёв, Валентина Николаевна Каширцева, Оксана Сергеевна Дружиловская, Дамир Вячеславович Игнатов, Ольга Михайловна Ипатова, Марина Викторовна Михайлова

Creative Commons License
Эта работа лицензирована Creative Commons Attribution 4.0 International License.

ISSN 2313-8416 (Online), ISSN 2313-6286 (Print)