DOI: https://doi.org/10.15587/2313-8416.2015.38849

Clinical significance of transforming growth factor β1 in the diagnosis of the severity of acute pancreatitis

Михаил Викторович Клименко

Abstract


Aim. Determine the clinical-diagnostic and prognostic value of transforming growth factor ß1 (TGF-ß1) at different degrees of severity of acute pancreatitis (AP) on the basis of studying the characteristics of content of anti-inflammatory cytokine in serum to create a diagnostic algorithm severity and course of AP.

Methods. It is analyzed the data for the study of nature of the transforming growth factor ß1 (TGF-ß1) content in the serum of 94 patients with AP varying severity (mild case of AP-20 patients, average case - 12, severe case -62) in the first 24-48 hours and 7-10 days of hospitalization.

Results. Analysis of the data can reliably assert that the value of TGF-ß1 in the first 48 hours of admission to correlate with AP severity. It is proposed the use of TGF-ß1 level in clinical and diagnostic complex of diagnostic of AP severity in the first 48 hours of hospitalization. If the patient has TGF-β1≤70.0 ng / ml it is mild AP. If the level of cytokine ≥70.1 ng / ml produce differentiation between moderate and severe AP. At the level of cytokine ≥120.1 ng / ml it is severe AP and diagnosis is completed. In the case of the definition of TGF-β1 in the range of> 80.1 - <120.0 ng / ml AP degree uncertain and requires further observation and examination.

Conclusions. Diagnostic thresholds of AP severity are determined. It is allowed use of TGF-β1 in a modern complex AP diagnostics. It is proven a diagnostic and prognostic significance level of anti-inflammatory cytokine TGF-ß1


Keywords


transforming growth factor-ß1; acute pancreatitis; severity; diagnosis

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