Aktualne spojrzenie na masywny krwotok actual view-point for massive hemorrhage

Authors

  • Zbigniew Rybicki Military Medical Institute in Warsaw ul. Szaserów 128, Warsaw Mazowieckie, Poland, 04-141, Poland

DOI:

https://doi.org/10.15587/2313-8416.2015.42078

Keywords:

coagulopathy, hemorrhage, war activities, terrorism, fibrinogen supplementation, thromboelastography

Abstract

A massive hemorrhage is the main cause of death in injures caused by war activities, terrorism, and transpotration accidens.The total loss of blood during 24 hours is considered to be massive hemorrhage.

The first hours of hemorrhage are connected with a decline of coagulation potential and with development of coagulopathy,witch when combined with a drop of body temperature and a developing metabolic acidosis constitutes a very serious life,s threat.

Therefore,the current approach to the treatment of massive hemorrhage is based on the avoidance of an excessive transfusion od blood substitute fluids ,because this leads to a dilution of components of coagulation ,and instead focused on-as aerly as  possibile an  application of full blood or products from blood particulary those that increase a coagulation potential.Most often  it is a FFP ( fresh frozen plasma),or PCC (prothrombin complex concentrate)

A special attention is paid to fibrinogen supplementation (usually 2,5–5,0 g/adult and 1–2 g/child is needed),so that it,s level in serum exceeds 150mg/dl.The source of fibrinogen other that FFP are crioprecipitat (0,4g/100ml) and fibrinogen  concentrat ( Haemocomplletan®).

Thromboelastography is recommended for a lab diagnosis of massive hemorrhage.

The basic rule of the initial treatment that determines  victim,s future outcome is the demage control resuscitation ,that is,performing only those  procedures that are absolutely necessary to save life.

With regard to hemorrhage here they are:

1. Stop loos of blood with nonsugical or surgical methods depending on their availability.

2. Blood transfusion( particulary fresh or fresh / warm ) or blood products  with special attention given to fibrynogen supplementation.

3. While transfusing blood products are performing  has to keep a ratio erythrocytes/thrombocytes/FFP 1:1:1.The level of hemoglobin must be a minimum 7g/dl,fibrinogen 150mg/dl and thrombocytes 100 000/ml

4. Prevent dropping body,s temperature.

5. Restrict transfusion of fluids such as cristaloids an particulary  artificial coloids to a bare minimum.No more that 700 ml in case that hemostasis was not performed.

6. Supplemented calcium so that its ionized level does not drop below 0.9 mmol/l.

7. Stabilize broken bons ,because its decreases secondary blood loss.

8. Prophylacticly prescribe a wide spectrum antibiotic

9. Transport a victim patient to higher level hospital.

Author Biography

Zbigniew Rybicki, Military Medical Institute in Warsaw ul. Szaserów 128, Warsaw Mazowieckie, Poland, 04-141

Department of Anaesthesiology and Intensive Care

References

Ogura, T., Nakamura, Y., Nakano, M., Izawa, Y., Nakamura, M., Fujizuka, K. et. al. (2014). Predicting the need for massive transfusion in trauma patients. Journal of Trauma and Acute Care Surgery, 76 (5), 1243–1250. doi: 10.1097/ta.0000000000000200

Rentas, F., Lincoln, D., Harding, A., Maas, P., Giglio, J., Fryar, R. et. al. (2012). The Armed Services Blood Program. Journal of Trauma and Acute Care Surgery, 73, 472–478. doi: 10.1097/ta.0b013e31827546e4

Grottke, O. (2012). Coagulation management. Current Opinion in Critical Care, 18 (6), 641–646. doi: 10.1097/mcc.0b013e328358e254

Esmon, C. (2000). The protein C pathway. Critical Care Medicine, 28, 44–48. doi: 10.1097/00003246-200009001-00010

Cohen, M. J., Call, M., Nelson, M., Calfee, C. S., Esmon, C. T., Brohi, K., Pittet, J. F. (2012). Critical Role of Activated Protein C in Early Coagulopathy and Later Organ Failure, Infection and Death in Trauma Patients. Annals of Surgery, 255 (2), 379–385. doi: 10.1097/sla.0b013e318235d9e6

Sperry, J. L., Nathens, A. B., Frankel, H. L., Vanek, S. L., Moore, E. E., Maier, R. V., Minei, J. P. (2008). Characterization of the gender dimorphism after injury and hemorrhagic shock: Are hormonal differences responsible?*. Critical Care Medicine, 36 (6), 1838–1845. doi: 10.1097/ccm.0b013e3181760c14

Ley, E. J., Clond, M. A., Srour, M. K., Barnajian, M., Mirocha, J., Margulies, D. R., & Salim, A. (2011). Emergency Department Crystalloid Resuscitation of 1.5 L or More is Associated With Increased Mortality in Elderly and Nonelderly Trauma Patients. The Journal of Trauma: Injury, Infection, and Critical Care, 70(2), 398–400. doi: 10.1097/ta.0b013e318208f99b

Trzebicki, J. i wsp. (2009). Tromboelastometria – nowa metoda wspomagającadecyzje terapeutyczne w zaburzeniach hemostazy, oparta na tromboelastografii Harteta. Polski Merkuriusz Lekarski, XXVII, 85.

Woźniak, D. i wsp. (2011). Tromboelastografia, metoda szybkiej diagnostyki zaburzeń układu krzepnięcia. Anestezjologia Intensywna Terapia, 43, 244.

Holley, A. D., Reade, M. C. (2013). The procoagulopathy of trauma: to much, too late. Current Opinion in Critical Care, 19, 578. doi: 10.1097/mcc.0000000000000032

Lier, H., Böttiger, B. W., Hinkelbein, J., Krep, H., & Bernhard, M. (2011). Coagulation management in multiple trauma: a systematic review. Intensive Care Medicine, 37(4), 572–582. doi: 10.1007/s00134-011-2139-y

Lichte, P., Kobbe, P., Dombroski, D., Pape, H. C. (2012). Damage control orthopedics: current evidence. Current Opinion in Critical Care, 18 (6), 647–650. doi: 10.1097/mcc.0b013e328359fd57

Rosenfeld, J. V. (2004). Damage control neurosurgery. Injury, 35 (7), 655–660. doi: 10.1016/j.injury.2004.03.006

Rall, J. M., Cox, J. M., Songer, A. G., Cestero, R. F., Ross, J. D. (2013). Comparison of novel hemostatic dressings with QuikClot combat gauze in a standardized swine model of uncontrolled hemorrhage. Journal of Trauma and Acute Care Surgery, 75, 150–156. doi: 10.1097/ta.0b013e318299d909

Kheirabadi, B. S., Terrazas, I. B., Hanson, M. A., Kragh, J. F., Dubick, M. A., Blackbourne, L. H. (2013). In vivo assessment of the Combat Ready Clamp to control junctional hemorrhage in swine. Journal of Trauma and Acute Care Surgery, 74 (5), 1260–1265. doi: 10.1097/ta.0b013e31828cc983

Stinger, H. K., Spinella, P. C., Perkins, J. G., Grathwohl, K. W., Salinas, J., Martini, W. Z. et. al. (2008). The Ratio of Fibrinogen to Red Cells Transfused Affects Survival in Casualties Receiving Massive Transfusions at an Army Combat Support Hospital. The Journal of Trauma: Injury, Infection, and Critical Care, 64, 79–85. doi: 10.1097/ta.0b013e318160a57b

Holcomb, J. B., Fox, E. E., Zhang, X., White, N., Wade, C. E., Cotton, B. A. et. al. (2013). Cryoprecipitate use in the PROMMTT study. Journal of Trauma and Acute Care Surgery, 75, 31–39. doi: 10.1097/ta.0b013e31828fa3ed

Wafaisade, A., Lefering, R., Maegele, M., Brockamp, T., Mutschler, M., Lendemans, S. et. al. (2013). Trauma Registry of DGU: Administration of fibrinogen concentrate in exsanguinating trauma patients is associated with improved survival at 6 hours but not at discharge. Journal of Trauma and Acute Care Surgery, 74 (2), 387–395. doi: 10.1097/ta.0b013e31827e2410

Schöchl, H., Nienaber, U., Hofer, G., Voelckel, W., Jambor, C., Scharbert, G. et. al. (2010). Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM®)-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Critical Care, 14 (2), 55. doi: 10.1186/cc8948

Joseph, B., Hadjizacharia, P., Aziz, H., Kulvatunyou, N., Tang, A., Pandit, V. et. al. (2013). Prothrombin complex concentrate: an effective therapy in reversing the coagulopathy of traumatic brain injury. Journal of Trauma and Acute Care Surgery, 74 (1), 248–253. doi: 10.1097/ta.0b013e3182788a40

Joseph, B., Amini, A., Friese, R. S., Houdek, M., Hays, D., Kulvatunyou, N., Wynne, J., O'Keeffe, T., Latifi, R., Rhee, P. (2012). Factor IX complex for the correction of traumatic coagulopathy. Journal of Trauma and Acute Care Surgery, 72 (4), 828–834. doi: 10.1097/TA.0b013e318247c944

Brown, L. M., Aro, S. O., Cohen, M. J. (2011). A High Fresh Frozen Plasma: Packed Red Blood Cell Transfusion Ratio Decreases Mortality in All Massively Transfused Trauma Patients Regardless of Admission International Normalized Ratio. The Journal of Trauma: Injury, Infection, and Critical Care, 71, 358–363. doi: 10.1097/ta.0b013e318227f152

McCully, S. P., Fabricant, L. J., Kunio, N. R., Groat, T. L., Watson, K. M., Differding, J. A. et. al. (2013). The International Normalized Ratio overestimates coagulopathy in stable trauma and surgical patients. Journal of Trauma and Acute Care Surgery, 75 (6), 947–953. doi: 10.1097/ta.0b013e3182a9676c

Pidcoke, H. F., Aden, J. K., Mora, A. G., Borgman, M. A., Spinella, P. C., Dubick, M. A. et. al. (2012). Ten-year analysis of transfusion in Operation Iraqi Freedom and Operation Enduring Freedom. Journal of Trauma and Acute Care Surgery, 73, 445–452. doi: 10.1097/ta.0b013e3182754796

Holcomb, J. B., Zarzabal, L. A., Michalek, J. E., Kozar, R. A., Spinella, P. C., Perkins, J. G. et. al. (2011). Increased Platelet:RBC Ratios Are Associated With Improved Survival After Massive Transfusion. The Journal of Trauma: Injury, Infection, and Critical Care, 71, 318–328. doi: 10.1097/ta.0b013e318227edbb

Brown, L. M., Call, M. S., Margaret Knudson, M., Cohen, M. J. (2011). A Normal Platelet Count May Not Be Enough: The Impact of Admission Platelet Count on Mortality and Transfusion in Severely Injured Trauma Patients. The Journal of Trauma: Injury, Infection, and Critical Care, 71, 337–342. doi: 10.1097/ta.0b013e318227f67c

Rentas, F., Lincoln, D., Harding, A., Maas, P., Giglio, J., Fryar, R. et. al. (2012). The Armed Services Blood Program. Journal of Trauma and Acute Care Surgery, 73, 472–478. doi: 10.1097/ta.0b013e31827546e4

Ho, A. M.-H., Dion, P. W., Yeung, J. H. H., Holcomb, J. B., Critchley, L. A. H., Ng, C. S. H. (2012). Prevalence of Survivor Bias in Observational Studies on Fresh Frozen Plasma. Anesthesiology, 116 (3), 716–728. doi: 10.1097/aln.0b013e318245c47b

Davenport, R., Curry, N., Manson, J., DeʼAth, H., Coates, A., Rourke, C. et. al. (2011). Hemostatic Effects of Fresh Frozen Plasma May be Maximal at Red Cell Ratios of 1:2. The Journal of Trauma: Injury, Infection, and Critical Care, 70 (1), 90–96. doi: 10.1097/ta.0b013e318202e486

Elterman, J., Brasel, K., Brown, S., Bulger, E., Christenson, J., Kerby, J. D. (2013). Transfusion of red blood cells in patients with a prehospital Glasgow Coma Scale score of 8 or less and no evidence of shock is associated with worse outcomes. Journal of Trauma and Acute Care Surgery, 75 (1), 8–14. doi: 10.1097/ta.0b013e318298492e

Theusinger, O. M., Stein, P., Spahn, D. R. (2014). Transfusion strategy in multiple trauma patients. Current Opinion in Critical Care, 20 (6), 646–655. doi: 10.1097/mcc.0000000000000152

Ryan, M. L., Thorson, C. M., Otero, C. A., Vu, T., Schulman, C. I., Livingstone, A. S., Proctor, K. G. (2012). Initial hematocrit in trauma: a paradigm shift? Journal of Trauma and Acute Care Surgery, 72 (1), 54–59. doi: 10.1097/TA.0b013e31823d0f35

Rahbar, E., Fox, E. E., del Junco, D. J., Harvin, J. A., Holcomb, J. B., Wade, C. E. et. al. (2013). PROMMIT StudyGroup: Early resuscitation intensity as a surrogate for bleeding severity and early mortality in the PROMMTT study. Journal of Trauma and Acute Care Surgery, 75, 16–23. doi: 10.1097/ta.0b013e31828fa535

Repine, T. B., Perkins, J. G., Kauvar, D. S., Blackborne, L. (2006). The Use of Fresh Whole Blood in Massive Transfusion. The Journal of Trauma: Injury, Infection, and Critical Care, 60, 59–69. doi: 10.1097/01.ta.0000219013.64168.b2

Cotton, B. A., Harvin, J. A., Kostousouv, V., Minei, K. M., Radwan, Z. A., Schöchl, H. et. al. (2012). Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration. Journal of Trauma and Acute Care Surgery, 73 (2), 365–370. doi: 10.1097/ta.0b013e31825c1234

Chapman, M. P., Moore, E. E., Ramos, C. R., Ghasabyan, A., Harr, J. N., Chin, T. L. et. al. (2013). Fibrinolysis greater than 3 % is the critical value for initiation of antifibrinolytic therapy. Journal of Trauma and Acute Care Surgery, 75 (6), 961–967. doi: 10.1097/ta.0b013e3182aa9c9f

CRASH-2 trial collaborators, Shakur H. et al.: Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial (2010). Lancet, 376, 23.

Morrison, J. J. (2012). Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study. Archives of Surgery, 147 (2), 113. doi: 10.1001/archsurg.2011.287

Morrison, J. J., Ross, J. D., Dubose, J. J., Jansen, J. O., Midwinter, M. J., Rasmussen, T. E. (2013). Association of Cryoprecipitate and Tranexamic Acid With Improved Survival Following Wartime Injury. JAMA Surgery, 148 (3), 218. doi: 10.1001/jamasurg.2013.764

CRASH-2 Collaborators, Intracranial Bleeding Study: Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study) (2011). BMJ, 343, 3795

Eckert, M. J., Wertin, T. M., Tyner, S. D., Nelson, D. W., Izenberg, S., Martin, M. J. (2014). Tranexamic acid administration to pediatric trauma patients in a combat setting. Journal of Trauma and Acute Care Surgery, 77 (6), 852–858. doi: 10.1097/ta.0000000000000443

Valle, E. J., Allen, C. J., Van Haren, R. M., Jouria, J. M., Li, H., Livingstone, A. S. et. al. (2014). Do all trauma patients benefit from tranexamic acid? Journal of Trauma and Acute Care Surgery, 76 (6), 1373–1378. doi: 10.1097/ta.0000000000000242

Theusinger, O. M. (2012). The Inhibiting Effect of Factor XIII on Hyperfibrinolysis. Anesthesia & Analgesia, 114(6), 1149–1150. doi: 10.1213/ane.0b013e318252e9f1

Dutton, R. P., McCunn, M., Hyder, M., D’Angelo, M., O’Connor, J., Hess, J. R., Scalea, T. M. (2004). Factor VIIa for Correction of Traumatic Coagulopathy. The Journal of Trauma: Injury, Infection, and Critical Care, 57 (4), 709–719. doi: 10.1097/01.ta.0000140646.66852.ab

Spinella, P. C., Perkins, J. G., McLaughlin, D. F., Niles, S. E., Grathwohl, K. W., Beekley, A. C. et. al .(2008). The Effect of Recombinant Activated Factor VII on Mortality in Combat-Related Casualties With Severe Trauma and Massive Transfusion. The Journal of Trauma: Injury, Infection, and Critical Care, 64 (2), 286–294. doi: 10.1097/ta.0b013e318162759f

Boffard, K. D., Riou, B., Warren, B., Choong, P. I. T., Rizoli, S., Rossaint, R. et. al. (2005). NovoSeven Trauma Study Group: Recombinant Factor VIIa as Adjunctive Therapy for Bleeding Control in Severely Injured Trauma Patients: Two Parallel Randomized, Placebo-Controlled, Double-Blind Clinical Trials. The Journal of Trauma: Injury, Infection, and Critical Care, 59 (1), 8–18. doi: 10.1097/01.ta.0000171453.37949.b7

Hauser, C. J., Boffard, K., Dutton, R., Bernard, G. R., Croce, M. A., Holcomb, J. B. et. al. (2010). Results of the CONTROL Trial: Efficacy and Safety of Recombinant Activated Factor VII in the Management of Refractory Traumatic Hemorrhage. The Journal of Trauma: Injury, Infection, and Critical Care, 69 (3), 489–500. doi: 10.1097/ta.0b013e3181edf36e

Cotton, B. A., Jerome, R., Collier, B. R., Khetarpal, S., Holevar, M., Tucker, B. et. al .(2009). Guidelines for Prehospital Fluid Resuscitation in the Injured Patient. The Journal of Trauma: Injury, Infection, and Critical Care, 67 (2), 389–402. doi: 10.1097/ta.0b013e3181a8b26f

Duke, M. D., Guidry, C., Guice, J., Stuke, L., Marr, A. B., Hunt, J. P. et. al. (2012). Restrictive fluid resuscitation in combination with damage control resuscitation. Journal of Trauma and Acute Care Surgery, 73 (3), 674–678. doi: 10.1097/ta.0b013e318265ce1f

Hampton, D. A., Fabricant, L. J., Differding, J., Diggs, B., Underwood, S., De La Cruz, D. et. al. (2013). Prehospital intravenous fluid is associated with increased survival in trauma patients. Journal of Trauma and Acute Care Surgery, 75, 9–15. doi: 10.1097/ta.0b013e318290cd52

Schnüriger, B., Inaba, K., Wu, T., Eberle, B. M., Belzberg, H., Demetriades, D. (2011). Crystalloids After Primary Colon Resection and Anastomosis at Initial Trauma Laparotomy: Excessive Volumes Are Associated With Anastomotic Leakage. The Journal of Trauma: Injury, Infection, and Critical Care, 70 (3), 603–610. doi: 10.1097/ta.0b013e3182092abb

Asehnoune, K., Faraoni, D., Brohi, K. (2014). What’s new in management of traumatic coagulopathy? Intensive Care Medicine, 40 (11), 1727–1730. doi: 10.1007/s00134-014-3388-3

Published

2015-04-28

Issue

Section

Medical