Oxidative stress and mitochondrial dysfunction in infected pregnant

Нана Мерабівна Пасієшвілі


The infected pregnant women have been various perinatal complications. The aim of the work was to clarify the role of oxidative stress and mitochondrial dysfunction in the development of perinatal complications in infected pregnant.

Methods. The study included 68 pregnant women with signs of maternal-fetal infection (MFI) and 30 pregnant women who were found infected (control group). Later pregnant with MFI were divided into 2 groups: the first included 30 women who received traditional antibacterial and antiviral therapy, the second group consisted of 28 women who were additionally given an immunomodulator in combination with ozone therapy.

Results. During pregnancy with MFI it is characterized the thrombophilic disorders, break immune homeostasis pregnant, endothelial dysfunction, which adversely affects perinatal indicators.

Conclusions. The use of immunomodulators and ozone therapy in the complex treatment of MFI is pathogenetically substantiated effective treatment of oxidative stress and mitochondrial toxicity in the prevention of perinatal complications in infected women


oxidative stress; mitochondrial dysfunction; maternal-fetal infection; medical ozone; immunotherapy


Thirsk, Y. I., Belkova, T. N., Rudakova, E. B. (2011). Medical Management of intrauterine infection. Obstetrics and ginekologiya, 8, 42–47.

Tyutyunnik, V. L., Karapetyan, T. E., Donnikov, A. E. (2013). Changes in the local and systemic immunity for opportunistic infections of the vagina in pregnant. Obstetrics and ginekologiya, 8, 25–29.

Shestakov, O. I., Podrez, L. A., Baranov, I. I. (2011). The role of endotoxin in the diagnosis of postpartum complications. Obstetrics and ginekologiya, 6, 53–57.

Voronov, I. I., Demin, T. N. (2010). Immune factors as the cause of complications of pregnancy. Zb. nauk. prats Asots. Akusha-gіnek. Ukraini. Kiev: Іntermed, 53–57.

Roly, L. V., Safronova, V. G., Matveeva, N. K., Suhih, G. T. (2010). Oxidative stress in the genesis of obstetric complications. Moscow: GEOTAR Media, 264.

Peter Stein, T., Scholl, T. O., Schluter, M. D., Leskiw, M. J., Chen, X., Spur, B. W., Rodriguez, A. (2008). Oxidative stress early in pregnancy and pregnancy outcome. Free Radic Res, 42 (10), 841–848. doi: 10.1080/10715760802510069

Raijmakers, M. T. M., Roes, E. M., Poston, L., Steegers, E. A. P., Peters, W. H. M. (2008). The transient increase of oxidative stress during normal pregnancy is higher and persists after delivery in women with pre-eclampsia. European Journal of Obstetrics & Gynecology and Reproductive Biology, 138 (1), 39–44. doi: 10.1016/j.ejogrb.2007.08.005

Karpishchenko, A. I. (2013). Medical laboratory tehnologii. Moscow: GEOTAR Media, 792.

GOST Style Citations

1. Тирская, Ю. И. Врачебная тактика при внутриутробных инфекциях [Текст] / Ю. И. Тирская, Т. Н. Белкова, Е. Б. Рудакова // Акушерство и гинекология. – 2011. – № 8. – С. 42–47.

2. Тютюнник, В. Л. Изменения локального и системного иммунитета при оппортунистических инфекциях влагалища у беременных [Текст] / В. Л. Тютюнник, Т. Э. Карапетян, А. Е. Донников // Акушерство и гинекология. – 2013. – № 8. – С. 25–29.

3. Шестакова, О. И. Роль эндотоксина в диагностике осложнений послеродового периода [Текст] / О. И. Шестакова, Л. А. Подрез, И. И. Баранов // Акушерство и гинекология. – 2011. – № 6. – С. 53–57.

4. Воронова, И. И. Иммунные факторы как причина осложнения протекания беременности [Текст]: зб. наук. пр. / И. И. Воронова, Т. Н. Демина // Асоц. акуш-гінек. України. – К.: Інтермед, 2010. – С. 53–57.

5. Ванько, Л. В. Оксидативный стресс в генезе акушерских осложнений [Текст] / Л. В. Ванько, В. Г. Сафронова, Н. К. Матвеева, Г. Т. Сухих. – М.: ГЭОТАР-Медиа, 2010. – 264 с.

6. Peter Stein, T. Oxidative stress early in pregnancy and pregnancy outcome [Text] / T. Peter Stein, T. O. Scholl, M. D. Schluter, M. J. Leskiw, X. Chen, B. W. Spur, A. Rodriguez // Free Radical Research. – 2008. – Vol. 42, Issue 10. – P. 841–848. doi: 10.1080/10715760802510069 

7. Raijmakers, M. T. The transient increase of oxidative stress during normal pregnancy is higher and persists after delivery in women with pre-eclampsia [Text] / M. T. Raijmakers, E. M. Roes, L. Poston, E. A. P. Steegers, W. H. M. Peters // European Journal of Obstetrics & Gynecology and Reproductive Biology. – 2008. – Vol. 138, Issue 1. – P. 39–44. doi: 10.1016/j.ejogrb.2007.08.005 

8. Карпищенко, А. И. Медицинские лабораторные технологии [Текст] / А. И. Карпищенко. – М.: ГЭОТАР-Медиа, 2013. – 792 с.

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