DOI: https://doi.org/10.15587/2313-8416.2015.42080

Oxidative stress and mitochondrial dysfunction in infected pregnant

Нана Мерабівна Пасієшвілі

Abstract


The infected pregnant women have been various perinatal complications. The aim of the work was to clarify the role of oxidative stress and mitochondrial dysfunction in the development of perinatal complications in infected pregnant.

Methods. The study included 68 pregnant women with signs of maternal-fetal infection (MFI) and 30 pregnant women who were found infected (control group). Later pregnant with MFI were divided into 2 groups: the first included 30 women who received traditional antibacterial and antiviral therapy, the second group consisted of 28 women who were additionally given an immunomodulator in combination with ozone therapy.

Results. During pregnancy with MFI it is characterized the thrombophilic disorders, break immune homeostasis pregnant, endothelial dysfunction, which adversely affects perinatal indicators.

Conclusions. The use of immunomodulators and ozone therapy in the complex treatment of MFI is pathogenetically substantiated effective treatment of oxidative stress and mitochondrial toxicity in the prevention of perinatal complications in infected women


Keywords


oxidative stress; mitochondrial dysfunction; maternal-fetal infection; medical ozone; immunotherapy

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