General principles of pathogenetically substantiated combined therapy of chronic acquired toxoplasmosis
Keywords:toxoplasmosis, immune system, sex hormones, clinical manifestations, dysfunction of liver, adaptive responses, compensatory abilities
Although latent infection with Toxoplasma gondii is among the most prevalent of human infections, it has been generally assumed that, except for congenital transmission, it is asymptomatic. Different conditions such as, number of parasite, virulence of the organism, genetic background, sex, dysfunction of liver and immunological status seem to affect the course of infection The demonstration that Toxoplasma infections can alter behavior, reproductive function, in patients has led to a reconsideration of this assumption.
Methods. 112 patients attended in the 6 Department of Kharkiv Regional Infectious Diseases Hospital № 22 (Department of Medical Parasitology and Tropical Diseases of Kharkiv Medical Academy of Postgraduate Education,) in Kharkiv, Ukraine were enrolled in the study. Forty four patients (39,3±4,6 %) were male and sixty eight (60,7±4,6 %) were female. The age of the patients was from 18 till 72 years.
Results. During chronic acquired toxoplasmosis (САT) identified the regularities of changes in the ratio of the immune system and the basal levels of sex hormones available informative methods, which made it possible to evaluate the severity of the flow chart and predict treatment outcome without resorting to complex research methods.
Conclusion. The host-parasite relationships and clinical manifestations of chronic toxoplasmosis depend largely on function of liver, protective and adaptive responses and compensatory abilities of the human body
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Bodnya, K. I., Bobrova, O. V., Kotsyna, S. S. (2009). The method of treatment of chronic acquired toxoplasmosis. Patent of Ukraine for useful model. А61К31/00. № 43188; declared 16.02.2009; published 10.08.2009, № 15.
Bodnya, K. I., Kotsyna, S. S. (2014). The method of treatment of chronic acquired toxoplasmosis of adults patients. Patent of Ukraine for useful model. А61К31/00. № 93627; declared 28.04.2014; published 10.10.2014, № 19.
Bodnya, K. I., Kotsyna, S. S. (2010). The method of treatment of chronic acquired toxoplasmosis of adults patients. Patent of Ukraine for useful model. А61К31/00. № 51377; declared 12.02.2010; published 12.07.2010, № 13.
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