Factors of early atherosclerosis in patients with essential hypertension, obesity and comorbid subclinical hypothyroidism
Keywords:subclinical hypothyroidism, obesity, hypertension, atherosclerosis, intima media thickness, thyroid-stimulating hormone, BMI, CRP
The study identified the factors of early atherosclerosis in patients with essential hypertension and obesity and comorbid subclinical hypothyroidism.
Aim: To identify factors that influence the development of atherosclerosis in patients with obesity, hypertension and comorbid subclinical hypothyroidism.
Methods. The study involved 75 patients, including 53 patients in the phase of subclinical hypothyroidism and 22 patients in the phase of euthyroidism. All the patients underwent measurement of anthropometric parameters. They were identified lipid profile, CRP, TSH, T4. Determination of IMT was performed using color Doppler ultrasound machine with a 7.5 MHz linear transducer. Statistical analysis was performed using the software SPSS 13.0.
Results. A study of patients showed that the comparison group matched for age, sex, BMI. The levels of atherogenic lipids and CRP were statistically higher in the subclinical hypothyroidism group compared with the control group. A mathematical analysis showed that TSH affects indicators such as the IMT, CRP and BMI.
In subclinical hypothyroidism group were statistically significantly higher levels of atherogenic lipids, CRP as compared with the control group. Mathematical analysis showed that the significant factors affecting the development of atherosclerosis in patients with obesity, hypertension and subclinical hypothyroidism are the level of thyroid-stimulating hormone, CRP and BMI.
Conclusions: Significant factors affecting the development of atherosclerosis in patients with obesity, hypertension and subclinical hypothyroidism is the TSH, CRP and BMI. The level of TSH above 10.2 mIU/L is associated with the development of atherosclerosis in patients with obesity, hypertension and subclinical hypothyroidism
Biondi, B. (2010). Thyroid and Obesity: An Intriguing Relationship. The Journal of Clinical Endocrinology & Metabolism, 95 (8), 3614–3617. doi: 10.1210/jc.2010-1245
Lorenz, M. W., Schaefer, C., Steinmetz, H., Sitzer, M. (2010). Is carotid intima media thickness useful for individual prediction of cardiovascular risk? Ten-year results from the Carotid Atherosclerosis Progression Study (CAPS). European Heart Journal, 31 (16), 2041–2048. doi: 10.1093/eurheartj/ehq189
Kim, S., Kyung, C., Park, J. S., Lee, S.-P., Kim, H. K., Ahn, C. W. et. al. (2015). Normal-weight obesity is associated with increased risk of subclinical atherosclerosis. Cardiovascular Diabetology, 14 (1), 58–64. doi: 10.1186/s12933-015-0220-5
Rodondi, N., den Elzen, W. P., Bauer, D. C. (2010). Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA, 304 (12), 1365–1374. doi: 10.1001/jama.2010.1786
Collet, T.-H., Gussekloo, J., Bauer, D. C., den Elzen, W. P. J., Cappola, A. R., Balmer, P. (2012). Subclinical Hyperthyroidism and the Risk of Coronary Heart Disease and Mortality. Archives of Internal Medicine, 172 (10), 799–809. doi: 10.1001/archinternmed.2012.402
Surks, M. I., Ortiz, E., Daniels, G. H., Sawin, C. T., Col, N. F., Cobin, R. H. et. al. (2004). Subclinical Thyroid Disease. JAMA, 291 (2), 228–238. doi: 10.1001/jama.291.2.228
Canaris, G. J., Manowitz, N. R., Mayor, G., Ridgway, E. C. (2000). The Colorado Thyroid Disease Prevalence Study. Archives of Internal Medicine, 160 (4), 526–534. doi: 10.1001/archinte.160.4.526
Gao, N., Zhang, W., Zhang, Y., Yang, Q., Chen, S. (2013). Carotid intima-media thickness in patients with subclinical hypothyroidism: A meta-analysis. Atherosclerosis, 227 (1), 18–25. doi: 10.1016/j.atherosclerosis.2012.10.070
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