Morphological diagnostics of serrated colorectal neoplasias
DOI:
https://doi.org/10.15587/2313-8416.2015.47561Keywords:
colon, serrated neoplasia, papillary-tubular neoplasia, histological structure, detection rate.Abstract
Serrated neoplasias (SN) – the sort of pre-cancerous condition of colorectal mucous membrane that have a high oncogenic potential.
Aim. of research – to carry out an analysis of SN cases with determination of its detection rate and peculiarities of histological structure.
Materials and methods of research. There were analyzed the results of morphological study of material of 187 diagnostic colonoscopies with biopsy.
Results and discussion. In 143 of 187 patients 143 (76 %) were detected 531colorectal neoplasias (CN). In 72 (77 %) men were detected 305 CN, in 72 (76 %) women- 225 CN (the difference is statistically unreliable (р> 0,1). At assessment of CN localization it was noticed that it was localized in the left part of colon reliably more often (76 %) (р <0,01). The detection rate of CN is - 0,75 (143/187), the detection index of CN - 2,76 (517/187). Altogether in 44 % (83/187; 95 % CI (confidence interval) 34,5-51,6) SN was diagnosed; in 64% (120/187; 95 % CI 57,1-70,7) - papillary -tubular neoplasias. In 33 % (63/187; 95 % CI 27,3-40,7) was observed simultaneous detection in the same patient SN and papillary tubular one. From the 517 CN 195 (38 %) turned out SN, 322 (62 %) – papillary-tubular. SN occur reliably more rarely than papillary-tubular ones (р <0,01; chance ratio 2,73; 95 % CI 2,12-3,51). On histological structure SN were both polypoid and flat.
Conclusions. SN is a frequent pathology of colorectal mucous membrane although it occur reliably more rarely than papillary-tubular neoplasias. Screening colonoscopy with biopsy is effective for diagnostics of pre-cancerous colorectal neoplasias such as SN.
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