DOI: https://doi.org/10.15587/2313-8416.2015.50605

Metabolic and hypoxic disorders in diabetic nephropathy development in children with diabetes mellitus type i

Виталий Григорьевич Майданник, Євгенія Анатоліївна Бурлака

Abstract


Introduction: Diabetic nephropathy is the main cause of death of patients with diabetes mellitus (DM) and the sign of its decompensation. The main mechanisms that form a ground of pathogenesis of diabetic nephropathy are – creation of the products of incomplete glycosylation, disorders in the system of vitamin D3.

Aim: to study the links and levels of metabolic disorders in children with DM type 1 and at diabetic nephropathy.

Material and methods: 26 children I0–16 years old with DM type 1 and diabetic nephropathy were examined during the study. An affinity of hemoglobin to oxygen and oxidation of lipids was defined using the method of spectrophotometry. The levels of cellular hypoxia marker HIF-1 was defined with Western Blotting method.

Results: In the group of children with firstly detected DM type 1 the high level of dissociation of hemoglobin and oxygen comparing with the control group was detected. In the group of children with developed diabetic nephropathy the level of marker was considerably lower than in the control group and patients with DM type 1. The high level of intracellular hypoxia was fixed in all patients comparing with the control. HIF-1 level was considerably higher in patients with nephropathy than in the group with DM type 1. 1 It was detected an increase of lipids oxidation coefficient depending on the level of compensation of DM type 1.

Discussion: We have studied the node indicators of base metabolic and hypoxic disorders in patients with DM type 1 and patients with diabetic nephropathy. The further study of markers and its interdependence in the network of disorders caused by the deficiency of vitamin D3 and disorders in system of apoptosis control especially in aspect of diabetic nephropathy progressing is a promising direction of prophylaxis schemes creation and diabetic nephropathy treatment


Keywords


diabetes mellitus type 1; diabetic nephropathy; metabolic disorders; hypoxia

References


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GOST Style Citations


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