Improvement of classification of real estate of railway transport
DOI:
https://doi.org/10.15587/2313-8416.2015.50759Keywords:
tuberculosis, model, treatment, dosage, side effects, izonazyd, pyridoxine, group, experiment, changeAbstract
It was proposed a method of determining the optimum ratio of doses of the most pronounced therapeutic effect and minimal side effects.
The aim of the study was to conduct morphological evaluation of lesions of internal organs (lungs, liver, kidneys, spleen) after treatment of experimental tuberculosis of guinea pigs different ratios of doses of isoniazid and pyridoxine hydro- chloride.
Methods: 50 guinea pigs infection dose of 1 mg Mycobacterium death porpoises from generalized tuberculosis occurs after an average of 45 days, at infection doses of 0.1–0.01 mg – after 60–70 days. Smaller doses of 0.0001 and 0.000001 mg cause chronic disease that ends in death.
Results: The optimal therapeutic effect is obtained by treating animals with experimental tuberculosis isoniazid at a dose of 32 mg/kg of vitamin B6 and
5 mg/kg body weight of the animal, thus completely disappeared phenomenon specific inflammation in the lungs, liver, kidneys and spleen. This phenomenon also disappeared perifocal nonspecific inflammation. Disappeared dystrophic and necrotic changes in the studied organs.
Conclusions: In the experiment Shuttle "INH – pyridoxine hydrochloride" 32 and 5 mg/kg respectively leads to a lack of specific and non-specific manifestations of inflammation in the lungs, liver, kidneys and spleen
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