DOI: https://doi.org/10.15587/2313-8416.2015.51286

About the question of comorbidity of bronchial asthma and allergic rhinitis at school age

Олена Костянтинівна Колоскова, Галина Анатоліївна Білик

Abstract


The aim of research was to establish clinical and epidemiological features of bronchial tubes remodeling in schoolchildren with bronchial asthma with comorbid allergic pathology for optimization of the dynamic observation and management of the main disease.

Methods: There were examined 114 schoolchildren with bronchial asthma separated into 2 clinical groups depending on comorbid allergic pathology presence: 1 clinical group – 55 patients without comorbid allergic pathology, 11 group – patients with clinical sings of other forms of allergic pathology. Schoolchildren underwent the complex clinical examination: numerical score using constellational clinical and instrumental control scale of bronchial asthma (BA), spirograph examination, examination of the content of vascular endothelial growth factor (VEGF), extracellular cationic proteins in supernatant fluid of sputum, the general immunoglobulin of Е (IgE) class and interleukin-4 and -5 (Il-4, Il-5) in the serum of peripheral blood.

Results: There were detected the probable differences in clinical course of BA that indicated the heavier character of disease in the 11 group of comparison. The content of VEGF and eosinophilic cationic proteins (ECP) in sputum of patients with comorbid allergic rhinitis exceeded the mean indicators of 1 group in 1,4 times. In patients of 11 clinical group took place the tendency to prevalence of allergic inflammation markers IgE and IL-4, IL5in the blood serum.

Conclusions: Comorbid clinical course of allergic rhinitis in children with bronchial asthma favors the heavier and longer course of the main disease and activates the processes of neoanginogenesis of respiratory tracks with following remodeling of bronchial tubes. An examination of sputum for the content eosinophilic cationic proteins and vascular endothelial growth factor is necessary for schoolchildren with bronchial asthma with comorbid allergic rhinitis for optimization of basic anti-inflammatory treatment


Keywords


bronchial asthma; comorbidity; allergic rhinitis; school-aged children; remodeling of bronchial tubes

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